North Carolina Diabetes Research Center

北卡罗来纳州糖尿病研究中心

• 批准号: 10609094
• 负责人: DONALD A. MCCLAIN
• 金额: $ 118.93万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-07 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609094
• 关键词: Address; Agriculture; Automobile Driving; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Cluster Analysis; Collaborations; Communities; Dedications; Diabetes Mellitus; Doctor of Philosophy; Education; Fostering; Funding; Future; Genomics; Goals; Grant; Infrastructure; Institution; Interdisciplinary Study; International; Leadership; Link; Methods; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; North Carolina; Pathway Analysis; Patients; Persons; Phenotype; Productivity; Proteomics; Recording of previous events; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Scientist; Services; Site; Solid; Techniques; Training; Training Programs; Training and Education; Translating; Translations; United States National Institutes of Health; Universities; Work; base; career; clinical care; diabetes risk; diabetic patient; epigenomics; forest; hospital care; innovation; inter-institutional; interest; medical schools; member; metabolomics; novel; outreach; programs; recruit; symposium; translational approach; translational pipeline; translational study

PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW This proposal seeks to create and support an interactive regional diabetes research community (184 members) across four premiere research institutions in North Carolina, who currently garner over $70 million annually for support of their diabetes research: Duke University (Duke) The University of North Carolina at Chapel Hill (UNC), Wake Forest School of Medicine (WF), and North Carolina A&T (NC A&T). The North Carolina Diabetes Research Center (NCDRC) will support Research Cores that represent unique strengths at each institution. These Cores will support studies of the current Research Base at each respective institution, but will also be made available to the other NCDRC institutions, where their use has been hampered by less easy access. An expanded Pilot and Feasibility Program will encourage use of these now regional Cores, bring to the field new investigators and young scientists, and draw those not previously working in the field. We will leverage the existing infrastructure at each institution’s NIH Clinical and Translational Science Award (CTSA) site, to guide investigators to other resources that enhance their scientific productivity and efficiency. The goal of this new Center is to create connectivity in the diabetes research community, thereby fostering new advances in basic and translational diabetes research. We will take advantage of the substantial pre-existing resources and capabilities at each institution, and connect investigators to resources unique to each campus, to maximize the ability of member investigators – whether new investigators or scientists new to diabetes research – to answer important questions across the spectrum of translational approaches. There is a history of collaboration in diabetes research among the four institutions. Most importantly for this application, however, are the unique strengths that can be shared among our campuses, and the enormous potential for a large and cohesive community of investigators to advance diabetes research further. Regional Core Resources to be directly supported by the NCDRC will include a Genomics and Proteomics Core, and a world-renowned Metabolomics Core, including not only a range of state-of-the-art analyses but equally importantly, interpretive services that are often a bottleneck for such resources. Expertise in the Advanced Clinical Sciences Methods Core will be focused on driving translation of discovery to clinical care of diabetes, emphasizing state-of-the-art methods. Each Core will offer specialized Research Navigators to guide diabetes-focused investigators. Finally, an Enrichment Program will plan and sponsor an annual symposium, reaching out to investigators whose work and techniques could inform diabetes research. Fellows supported on T32 or T35 training programs at Duke, UNC, and WF, whose work is evolving in a diabetes-relevant direction, will be a special focus for outreach.

项目摘要/摘要-中心概述

项目成果

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.

• DOI: 10.1016/j.molmet.2021.101261
• 发表时间: 2021-10
• 期刊: Molecular metabolism
• 影响因子: 8.1
• 作者: White PJ;McGarrah RW;Herman MA;Bain JR;Shah SH;Newgard CB
• 通讯作者: Newgard CB

Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.

分子亚型的代谢综合征和乳腺癌的风险：损益研究的分析。

• DOI: 10.1016/j.clbc.2021.11.004
• 发表时间: 2022-06
• 期刊: CLINICAL BREAST CANCER
• 影响因子: 3.1
• 作者: Akinyemiju, Tomi;Oyekunle, Taofik;Salako, Omolola;Gupta, Anjali;Alatise, Olusegun;Ogun, Gabriel;Adeniyi, Adewale;Deveaux, April;Hall, Allison;Ayandipo, Omobolaji;Olajide, Thomas;Olasehinde, Olalekan;Arowolo, Olukayode;Adisa, Adewale;Afuwape, Oludolapo;Olusanya, Aralola;Adegoke, Aderemi;Tollefsbol, Trygve O.;Arnett, Donna;Muehlbauer, Michael J.;Newgard, Christopher B.;Daramola, Adetola
• 通讯作者: Daramola, Adetola

Catabolism of fats and branched-chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose.

• DOI: 10.1002/edm2.448
• 发表时间: 2023-11
• 期刊: Endocrinology, diabetes & metabolism

Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.

• DOI: 10.1016/j.isci.2021.103635
• 发表时间: 2022-01-21
• 期刊: iScience
• 影响因子: 5.8
• 作者: Williams AS;Koves TR;Pettway YD;Draper JA;Slentz DH;Grimsrud PA;Ilkayeva OR;Muoio DM
• 通讯作者: Muoio DM

Post-Exercise Protein Intake May Reduce Time in Hypoglycemia Following Moderate-Intensity Continuous Exercise among Adults with Type 1 Diabetes.

• DOI: 10.3390/nu15194268
• 发表时间: 2023-10-06
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Muntis FR;Mayer-Davis EJ;Shaikh SR;Crandell J;Evenson KR;Smith-Ryan AE
• 通讯作者: Smith-Ryan AE