North Carolina Diabetes Research Center

北卡罗来纳州糖尿病研究中心

• 批准号: 10609094
• 负责人: DONALD A. MCCLAIN
• 金额: $ 118.93万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-07 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609094
• 关键词: Address; Agriculture; Automobile Driving; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Cluster Analysis; Collaborations; Communities; Dedications; Diabetes Mellitus; Doctor of Philosophy; Education; Fostering; Funding; Future; Genomics; Goals; Grant; Infrastructure; Institution; Interdisciplinary Study; International; Leadership; Link; Methods; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; North Carolina; Pathway Analysis; Patients; Persons; Phenotype; Productivity; Proteomics; Recording of previous events; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Scientist; Services; Site; Solid; Techniques; Training; Training Programs; Training and Education; Translating; Translations; United States National Institutes of Health; Universities; Work; base; career; clinical care; diabetes risk; diabetic patient; epigenomics; forest; hospital care; innovation; inter-institutional; interest; medical schools; member; metabolomics; novel; outreach; programs; recruit; symposium; translational approach; translational pipeline; translational study

PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW This proposal seeks to create and support an interactive regional diabetes research community (184 members) across four premiere research institutions in North Carolina, who currently garner over $70 million annually for support of their diabetes research: Duke University (Duke) The University of North Carolina at Chapel Hill (UNC), Wake Forest School of Medicine (WF), and North Carolina A&T (NC A&T). The North Carolina Diabetes Research Center (NCDRC) will support Research Cores that represent unique strengths at each institution. These Cores will support studies of the current Research Base at each respective institution, but will also be made available to the other NCDRC institutions, where their use has been hampered by less easy access. An expanded Pilot and Feasibility Program will encourage use of these now regional Cores, bring to the field new investigators and young scientists, and draw those not previously working in the field. We will leverage the existing infrastructure at each institution’s NIH Clinical and Translational Science Award (CTSA) site, to guide investigators to other resources that enhance their scientific productivity and efficiency. The goal of this new Center is to create connectivity in the diabetes research community, thereby fostering new advances in basic and translational diabetes research. We will take advantage of the substantial pre-existing resources and capabilities at each institution, and connect investigators to resources unique to each campus, to maximize the ability of member investigators – whether new investigators or scientists new to diabetes research – to answer important questions across the spectrum of translational approaches. There is a history of collaboration in diabetes research among the four institutions. Most importantly for this application, however, are the unique strengths that can be shared among our campuses, and the enormous potential for a large and cohesive community of investigators to advance diabetes research further. Regional Core Resources to be directly supported by the NCDRC will include a Genomics and Proteomics Core, and a world-renowned Metabolomics Core, including not only a range of state-of-the-art analyses but equally importantly, interpretive services that are often a bottleneck for such resources. Expertise in the Advanced Clinical Sciences Methods Core will be focused on driving translation of discovery to clinical care of diabetes, emphasizing state-of-the-art methods. Each Core will offer specialized Research Navigators to guide diabetes-focused investigators. Finally, an Enrichment Program will plan and sponsor an annual symposium, reaching out to investigators whose work and techniques could inform diabetes research. Fellows supported on T32 or T35 training programs at Duke, UNC, and WF, whose work is evolving in a diabetes-relevant direction, will be a special focus for outreach.

项目总结/摘要-中心概述 该提案旨在创建和支持一个互动的区域糖尿病研究社区（184名成员） 在北卡罗来纳州的四个首屈一指的研究机构，谁目前每年获得超过7000万美元， 支持他们的糖尿病研究：杜克大学（杜克）位于查佩尔山的北卡罗来纳州大学（北卡罗来纳州）， 维克森林医学院（WF）和北卡罗来纳州A&T（NC A&T）。北卡罗来纳州糖尿病 研究中心（NCDRC）将支持代表每个机构独特优势的研究核心。 这些核心将支持每个机构当前研究基地的研究，但也将 这些信息提供给国家儿童权利委员会的其他机构，因为这些机构的使用受到阻碍。一个 扩大的试点和可行性计划将鼓励使用这些现在的区域核心，为外地带来新的 研究人员和年轻的科学家，并吸引那些以前没有在该领域工作。我们将利用 每个机构NIH临床和转化科学奖（CTSA）所在地的现有基础设施，以指导 研究人员可以利用其他资源来提高他们的科学生产力和效率。这个新的目标 该中心旨在建立糖尿病研究社区的连通性，从而促进基础研究的新进展。 和转化型糖尿病研究。我们将利用现有的大量资源， 每个机构的能力，并将调查人员与每个校园特有的资源联系起来，以最大限度地提高 成员研究者的能力-无论是新的研究者还是新的糖尿病研究科学家-回答 翻译方法中的重要问题。有一个合作的历史， 糖尿病研究在四个机构之间。然而，对于该应用程序来说，最重要的是 优势，可以在我们的校园之间共享，以及巨大的潜力，一个大的和有凝聚力的 研究人员社区进一步推进糖尿病研究。区域核心资源将直接 由NCDRC支持的将包括基因组学和蛋白质组学核心，以及世界知名的代谢组学 核心，不仅包括一系列最先进的分析，还包括同样重要的解释服务， 往往是这些资源的瓶颈。高级临床科学方法核心的专业知识将是 专注于推动将发现转化为糖尿病的临床护理，强调最先进的方法。 每个核心将提供专门的研究导航员，以指导糖尿病为重点的研究人员。最后通过一个 丰富计划将计划和赞助一个年度研讨会，接触调查人员，他们的工作和 技术可以为糖尿病研究提供信息。研究员在杜克，马萨诸塞州， 和WF，其工作正在朝着与糖尿病相关的方向发展，将是外展的特别重点。

项目成果

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.

• DOI: 10.1016/j.molmet.2021.101261
• 发表时间: 2021-10
• 期刊: Molecular metabolism
• 影响因子: 8.1
• 作者: White PJ;McGarrah RW;Herman MA;Bain JR;Shah SH;Newgard CB
• 通讯作者: Newgard CB

Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.

分子亚型的代谢综合征和乳腺癌的风险：损益研究的分析。

• DOI: 10.1016/j.clbc.2021.11.004
• 发表时间: 2022-06
• 期刊: CLINICAL BREAST CANCER
• 影响因子: 3.1
• 作者: Akinyemiju, Tomi;Oyekunle, Taofik;Salako, Omolola;Gupta, Anjali;Alatise, Olusegun;Ogun, Gabriel;Adeniyi, Adewale;Deveaux, April;Hall, Allison;Ayandipo, Omobolaji;Olajide, Thomas;Olasehinde, Olalekan;Arowolo, Olukayode;Adisa, Adewale;Afuwape, Oludolapo;Olusanya, Aralola;Adegoke, Aderemi;Tollefsbol, Trygve O.;Arnett, Donna;Muehlbauer, Michael J.;Newgard, Christopher B.;Daramola, Adetola
• 通讯作者: Daramola, Adetola

Catabolism of fats and branched-chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose.

• DOI: 10.1002/edm2.448
• 发表时间: 2023-11
• 期刊: Endocrinology, diabetes & metabolism

Post-Exercise Protein Intake May Reduce Time in Hypoglycemia Following Moderate-Intensity Continuous Exercise among Adults with Type 1 Diabetes.

• DOI: 10.3390/nu15194268
• 发表时间: 2023-10-06
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Muntis FR;Mayer-Davis EJ;Shaikh SR;Crandell J;Evenson KR;Smith-Ryan AE
• 通讯作者: Smith-Ryan AE

Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.

• DOI: 10.1016/j.isci.2021.103635
• 发表时间: 2022-01-21
• 期刊: iScience
• 影响因子: 5.8
• 作者: Williams AS;Koves TR;Pettway YD;Draper JA;Slentz DH;Grimsrud PA;Ilkayeva OR;Muoio DM
• 通讯作者: Muoio DM