North Carolina Diabetes Research Center

项目摘要/摘要-中心概述 这项提议旨在创建和支持一个互动的区域糖尿病研究社区(184个成员) 在北卡罗来纳州的四个首屈一指的研究机构中，他们目前每年为 支持他们的糖尿病研究：杜克大学(Duke)北卡罗来纳大学教堂山分校(UNC)， 维克森林医学院(WF)和北卡罗来纳州A&T(NC A&T)。北卡罗来纳州的糖尿病 研究中心(NCDRC)将支持代表每个机构独特优势的研究核心。 这些核心将支持每个机构对当前研究基础的研究，但也将 向NCDRC的其他机构提供，但由于不太容易获得，这些机构的使用受到阻碍。一个 扩大的试点和可行性计划将鼓励使用这些现在的区域核心，为现场带来新的 调查人员和年轻科学家，并吸引那些以前没有在该领域工作的人。我们将利用 每个机构的NIH临床和翻译科学奖(CTSA)站点的现有基础设施，以指导 研究人员可以利用其他资源来提高他们的科学生产力和效率。这项新计划的目标是 中心的目标是在糖尿病研究社区建立联系，从而促进基础研究领域的新进展 和转化型糖尿病研究。我们将充分利用现有的大量资源，并 每个机构的能力，并将调查人员连接到每个校园特有的资源，以最大限度地 成员调查员--无论是新手调查员还是糖尿病研究新手--回答问题的能力 涉及各种翻译方法的重要问题。有合作的历史，在 四个机构之间的糖尿病研究。然而，对于此应用程序来说，最重要的是独特的 可以在我们的校园之间共享的优势，以及大型和有凝聚力的 研究人员社区进一步推进糖尿病研究。区域核心资源将直接 由NCDRC支持的将包括基因组学和蛋白质组学核心，以及世界知名的代谢组学 核心，不仅包括一系列最先进的分析，而且同样重要的是，解释服务 往往是此类资源的瓶颈。高级临床科学方法核心方面的专业知识将是 专注于推动将发现转化为糖尿病的临床护理，强调最先进的方法。 每个核心将提供专门的研究导航器，以指导专注于糖尿病的研究人员。最后，一个 丰富计划将计划和赞助一个年度研讨会，接触研究人员，他们的工作和 技术可以为糖尿病研究提供信息。北卡罗来纳州杜克大学T32或T35培训计划支持的研究员， WF的工作正朝着与糖尿病相关的方向发展，将成为外展的特别重点。

PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW This proposal seeks to create and support an interactive regional diabetes research community (184 members) across four premiere research institutions in North Carolina, who currently garner over $70 million annually for support of their diabetes research: Duke University (Duke) The University of North Carolina at Chapel Hill (UNC), Wake Forest School of Medicine (WF), and North Carolina A&T (NC A&T). The North Carolina Diabetes Research Center (NCDRC) will support Research Cores that represent unique strengths at each institution. These Cores will support studies of the current Research Base at each respective institution, but will also be made available to the other NCDRC institutions, where their use has been hampered by less easy access. An expanded Pilot and Feasibility Program will encourage use of these now regional Cores, bring to the field new investigators and young scientists, and draw those not previously working in the field. We will leverage the existing infrastructure at each institution’s NIH Clinical and Translational Science Award (CTSA) site, to guide investigators to other resources that enhance their scientific productivity and efficiency. The goal of this new Center is to create connectivity in the diabetes research community, thereby fostering new advances in basic and translational diabetes research. We will take advantage of the substantial pre-existing resources and capabilities at each institution, and connect investigators to resources unique to each campus, to maximize the ability of member investigators – whether new investigators or scientists new to diabetes research – to answer important questions across the spectrum of translational approaches. There is a history of collaboration in diabetes research among the four institutions. Most importantly for this application, however, are the unique strengths that can be shared among our campuses, and the enormous potential for a large and cohesive community of investigators to advance diabetes research further. Regional Core Resources to be directly supported by the NCDRC will include a Genomics and Proteomics Core, and a world-renowned Metabolomics Core, including not only a range of state-of-the-art analyses but equally importantly, interpretive services that are often a bottleneck for such resources. Expertise in the Advanced Clinical Sciences Methods Core will be focused on driving translation of discovery to clinical care of diabetes, emphasizing state-of-the-art methods. Each Core will offer specialized Research Navigators to guide diabetes-focused investigators. Finally, an Enrichment Program will plan and sponsor an annual symposium, reaching out to investigators whose work and techniques could inform diabetes research. Fellows supported on T32 or T35 training programs at Duke, UNC, and WF, whose work is evolving in a diabetes-relevant direction, will be a special focus for outreach.