Wake Forest Clinical and Translational Science Award

维克森林临床和转化科学奖

• 批准号: 10204146
• 负责人: DONALD A. MCCLAIN
• 金额: $ 392.8万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-13 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10204146
• 关键词: Academic support; Academy; Achievement; Address; Appalachian Region; Area; Biological Models; Caring; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Community Physician; Contracts; Data; Environment; Fostering; Foundations; Funding; Goals; Health; Health system; Healthcare; Healthcare Systems; Incentives; Informatics; Institutes; Institutional Review Boards; Interdisciplinary Study; Knowledge; Laboratories; Leadership; Learning; Link; Longevity; Mentors; Methods; Mission; Modeling; Multicenter Trials; NCI Scholars Program; North Carolina; Participant; Population; Positioning Attribute; Process; Program Development; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Support; Research Training; Resources; Role; Safety; Scholarship; Science; Scientific Advances and Accomplishments; Scientist; Special Population; Speed; Structure; System; TNFSF15 gene; Testing; Textiles; Training; Training Programs; Translational Research; Translations; Vision; Workforce Development; biomedical informatics; catalyst; data sharing; design; early-career faculty; education research; education resources; empowered; experience; forest; implementation science; improved; informatics infrastructure; innovation; member; next generation; nonhuman primate; population health; pre-clinical; precision medicine; programs; skills; success; tool; translational pipeline; workforce needs

Contact PD/PI: MCCLAIN, DONALD A. Summary: Overall When the Wake Forest (WF) Clinical and Translational Science Institute (CTSI) joined the CTSA consortium in August 2015, our goal was to use our resources to catalyze WF’s transformation into an exemplary Learning Health System in which “science, informatics, incentives, and culture are aligned for continuous improvement and innovation, with best practices seamlessly embedded in the delivery process and new knowledge captured as an integral by-product of the delivery experience.” We seek to extend this framework by integrating traditional academic goals of T0 – T4 discovery, translation, and scholarship to form a new vision—the Academic Learning Health System (aLHS). In our initial 3 years of funding, we have progressed towards our goal, establishing an integrated research governance model, with the CTSI at its core, to realize efficiencies and address roadblocks that hamper translational progress. We established Translational Catalysts to link the academic and clinical enterprises and designed training programs to develop the skills our workforce needs to make the aLHS a reality. We developed foundational informatics infrastructures essential to learning and growing, engaged communities and stakeholders to integrate diverse perspectives into the fabric of our aLHS, and created a milieu for nurturing innovative translational methods. We became a valued member of the CTSA national network, actively collaborating with 20 CTSA hubs, and shared our world-class nonhuman primate models with the consortium. With these successes, we turn to the next 5 years with strong assets in leadership, structure, scholarship, and culture that uniquely position us to realize the aLHS ideal. We will fully integrate our new Translational Catalysts – biomedical informatics, implementation science, precision medicine, healthcare innovation, and clinical trials – and use them, along with incentives for academic engagement, to mobilize our growing clinical network. We will develop, implement, and broadly disseminate improved methods and processes that will increase the efficiency, safety, and reproducibility of preclinical and clinical science. We will partner with our community to integrate special populations, and support health research across the lifespan. We will train our workforce for new roles, especially in team environments, with new training programs (e.g., TL1 aLHS Scholars Program, the Learning TREE online educational platform for individualized learning, Research-in-Action) and broaden our highly successful KL2 training for early-career faculty. We will serve as a hub for biomedical informatics, accelerating progress by enhancing existing resources, promoting collaboration and data sharing, and building new capacity. We will remain committed to inclusiveness, mutual respect, and multiple perspectives to act as a catalyst for change and healthy equity. We will further extend the reach of the aLHS into the communities served by our expanding health system and will broaden our collaborations with other CTSA hubs to share best practices and export the aLHS model – all guided by our ultimate goal of improving the health of our region and nation. Page 243 Project Summary/Abstract Contact PD/PI: MCCLAIN, DONALD A. Narrative: Overall The Wake Forest Clinical and Translational Science Institute seeks to become the model of an integrated Academic Learning Health System in which we develop, implement, offer tailored training tools, and broadly disseminate improved methods and processes to increase the efficiency, safety, and reproducibility of preclinical and clinical science. We will build on our achievements to fully integrate our new Translational Catalysts – biomedical informatics, implementation science, precision medicine, healthcare innovation and clinical trials – and use them to develop and test initiatives, deploying research findings across our growing clinical network. We will remain committed to training the next generation of scientists and leaders and will partner with our community and CTSA hubs to integrate special populations and support research across the lifespan to extend the benefits of our progress to the widest possible audience. Page 244

联系PD/PI：MCCLAIN，DONALD A. 摘要：总体 年，当维克森林（WF）临床和转化科学研究所（CTSI）加入CTSA联盟时， 2015年8月，我们的目标是利用我们的资源，促进WF转变为一个示范性的学习 卫生系统，其中“科学，信息学，激励措施和文化是一致的，以持续改进” 创新，最佳实践无缝嵌入交付流程，并获取新知识 作为交付体验不可或缺的副产品。”我们试图通过整合传统的 T0 - T4发现、翻译和学术的学术目标，形成一种新的视野--学术学习 卫生系统。在我们最初的3年资金，我们已经朝着我们的目标，建立一个 以CTSI为核心的综合研究治理模式，以实现效率和解决障碍 阻碍了转化的进程我们建立了转化催化剂，以连接学术和临床 企业和设计的培训计划，以发展我们的劳动力需要的技能，使aLHS成为现实。 我们开发了对于学习和发展、参与社区至关重要的基础信息学基础设施 和利益相关者将不同的观点融入我们的aLHS结构，并创造了一个环境， 创新的翻译方法。我们成为CTSA国家网络的重要成员，积极 与20个CTSA中心合作，并与该联盟分享我们世界级的非人类灵长类动物模型。 有了这些成功，我们转向未来5年，在领导，结构，奖学金和 文化，使我们能够实现aLHS的理想。我们将充分整合我们的新翻译催化剂 - 生物医学信息学、实施科学、精准医学、医疗创新和临床试验- 并利用它们，沿着激励学术参与，以调动我们不断增长的临床网络。我们将 制定、实施和广泛传播改进的方法和程序，以提高效率， 临床前和临床科学的安全性和再现性。我们将与社区合作， 特殊人群，并支持整个生命周期的健康研究。我们将为新的角色培训我们的员工， 特别是在团队环境中，使用新的培训计划（例如，TL 1 aLHS学者计划，学习 TREE在线教育平台，用于个性化学习，行动研究），并拓宽了我们的高度 为早期职业教师提供成功的KL 2培训。我们将成为生物医学信息学的中心， 通过增加现有资源、促进协作和数据共享以及建设新的能力，取得进展。 我们将继续致力于包容、相互尊重和多元视角， 变化和健康的公平。我们将进一步扩大aLHS的覆盖范围到我们所服务的社区。 扩大卫生系统，并将扩大我们与其他CTSA中心的合作，分享最佳实践， 输出aLHS模式--所有这些都以改善我们地区和国家的健康为最终目标。 第二百四十三页 项目总结/摘要 联系PD/PI：MCCLAIN，DONALD A. 叙述：总体 维克森林临床和转化科学研究所寻求成为一个综合的模式， 学术学习健康系统，我们开发，实施，提供量身定制的培训工具，并广泛 传播改进的方法和流程，以提高临床前研究的效率、安全性和重现性。 临床科学。我们将在我们的成就基础上，充分整合我们的新翻译催化剂- 生物医学信息学、实施科学、精准医学、医疗创新和临床试验- 并利用它们来开发和测试计划，在我们不断增长的临床网络中部署研究成果。 我们将继续致力于培训下一代科学家和领导者，并将与我们的合作伙伴合作 社区和CTSA中心，以整合特殊人群，并支持整个生命周期的研究， 向尽可能广泛的受众宣传我们的进步所带来的好处。 第244页