North Carolina Diabetes Research Center

北卡罗来纳州糖尿病研究中心

• 批准号: 10382306
• 负责人: DONALD A. MCCLAIN
• 金额: $ 119.76万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-07 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10382306
• 关键词: Address; Agriculture; Automobile Driving; Caring; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Cluster Analysis; Collaborations; Communities; Diabetes Mellitus; Doctor of Philosophy; Fostering; Funding; Future; Genomics; Goals; Grant; Hospitals; Infrastructure; Institution; Interdisciplinary Study; International; Leadership; Link; Methods; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; North Carolina; Pathway Analysis; Patients; Persons; Phenotype; Productivity; Proteomics; Recording of previous events; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Scientist; Services; Site; Solid; Techniques; Training; Training Programs; Training and Education; Translating; Translations; United States National Institutes of Health; Universities; Work; base; career; clinical care; cohesion; diabetes risk; diabetic patient; epigenomics; forest; innovation; inter-institutional; interest; medical schools; member; metabolomics; metabolomics resource; novel; outreach; programs; recruit; symposium; translational approach; translational pipeline; translational study

PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW This proposal seeks to create and support an interactive regional diabetes research community (184 members) across four premiere research institutions in North Carolina, who currently garner over $70 million annually for support of their diabetes research: Duke University (Duke) The University of North Carolina at Chapel Hill (UNC), Wake Forest School of Medicine (WF), and North Carolina A&T (NC A&T). The North Carolina Diabetes Research Center (NCDRC) will support Research Cores that represent unique strengths at each institution. These Cores will support studies of the current Research Base at each respective institution, but will also be made available to the other NCDRC institutions, where their use has been hampered by less easy access. An expanded Pilot and Feasibility Program will encourage use of these now regional Cores, bring to the field new investigators and young scientists, and draw those not previously working in the field. We will leverage the existing infrastructure at each institution’s NIH Clinical and Translational Science Award (CTSA) site, to guide investigators to other resources that enhance their scientific productivity and efficiency. The goal of this new Center is to create connectivity in the diabetes research community, thereby fostering new advances in basic and translational diabetes research. We will take advantage of the substantial pre-existing resources and capabilities at each institution, and connect investigators to resources unique to each campus, to maximize the ability of member investigators – whether new investigators or scientists new to diabetes research – to answer important questions across the spectrum of translational approaches. There is a history of collaboration in diabetes research among the four institutions. Most importantly for this application, however, are the unique strengths that can be shared among our campuses, and the enormous potential for a large and cohesive community of investigators to advance diabetes research further. Regional Core Resources to be directly supported by the NCDRC will include a Genomics and Proteomics Core, and a world-renowned Metabolomics Core, including not only a range of state-of-the-art analyses but equally importantly, interpretive services that are often a bottleneck for such resources. Expertise in the Advanced Clinical Sciences Methods Core will be focused on driving translation of discovery to clinical care of diabetes, emphasizing state-of-the-art methods. Each Core will offer specialized Research Navigators to guide diabetes-focused investigators. Finally, an Enrichment Program will plan and sponsor an annual symposium, reaching out to investigators whose work and techniques could inform diabetes research. Fellows supported on T32 or T35 training programs at Duke, UNC, and WF, whose work is evolving in a diabetes-relevant direction, will be a special focus for outreach.

项目摘要/摘要 - 中心概述 该建议旨在创建和支持交互式区域糖尿病研究社区（184名成员） 在北卡罗来纳州的四家首映研究机构中，目前每年收入超过7,000万美元 支持他们的糖尿病研究：杜克大学（杜克大学）北卡罗来纳大学教堂山（UNC）， 韦克森林医学院（WF）和北卡罗来纳州A＆T（NC A＆T）。北卡罗来纳州糖尿病 研究中心（NCDRC）将支持代表每个机构独特优势的研究核心。 这些核心将支持每个相对机构当前研究基础的研究，但也将是 可用于其他NCDRC机构，在这些机构中，它们的使用受到较不容易访问的阻碍。一个 扩大的飞行员和可行性计划将鼓励使用这些现在的区域核心，将其带入新的领域 调查人员和年轻科学家，并绘制那些以前从未在该领域工作的人。我们将利用 每个机构的NIH临床和转化科学奖（CTSA）网站上的现有基础设施，以指导 研究人员到其他资源，以提高其科学生产力和效率。这个新的目标 中心是在糖尿病研究界建立连通性，从而促进基本的新进步 并翻译糖尿病研究。我们将利用大量现有资源和 每个机构的能力，并将调查人员连接到每个校园独有的资源，以最大化 会员研究人员的能力 - 新研究者还是糖尿病研究的科学家，可以回答 转化方法范围内的重要问题。有合作的历史 这四个机构之间的糖尿病研究。但是，对于此应用程序最重要的是独特的 可以在我们的校园之间分享的优势，以及巨大而凝聚力的巨大潜力 调查人员社区进一步推进糖尿病研究。区域核心资源直接 NCDRC支持将包括基因组学和蛋白质组学核心，以及世界知名的代谢组学 核心，不仅包括一系列最新分析，而且包括同样重要的是解释性服务 通常是这种资源的瓶颈。高级临床科学方法的专业知识将是 专注于将发现转化为糖尿病的临床护理，强调最先进的方法。 每个核心将为专门的研究导航员指导以糖尿病为中心的研究人员。最后，一个 丰富计划将计划和赞助年度研讨会，与工作和工作的调查人员联系 技术可以为糖尿病研究提供信息。在UNC，UNC，UNC，UNC，UNC的T32或T35培训计划中支持的研究员 WF的工作正在朝着与糖尿病有关的方向发展，这将是外展活动的特别重点。