Multiethnic Validation of VCID biomarkers in South Texas
德克萨斯州南部 VCID 生物标志物的多种族验证
基本信息
- 批准号:10611823
- 负责人:
- 金额:$ 119.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
ABSTRACT
Cerebral small vessel disease (CSVD) contributes considerably to the global burden of dementia. As vascular diseases can be both prevented and safely treated, there is a great potential for interventions to reduce the burden of dementia. However, more research is needed to develop suitable biomarkers of cerebral small vessel contributions to cognitive impairment and dementia (VCID). The National Institute of Neurological Disorders and Stroke (NINDS) has supported the MarkVCID initiative to advance the identification and validation of biomarkers for VCID across seven sites and a coordinating center. As one contributing site, our team has led the development of two candidate biomarkers, helped define and harmonize all protocols, and joined multisite validation with the recruitment of the largest Hispanic sample from a single site. In this proposal, we seek to include a more diverse population across South Texas, including Hispanic and African Americans, from Houston and San Antonio, stroke and dementia clinics, primary care, and population studies. We further propose additional validation of candidate biomarkers in the rich datasets of four cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium that have legacy data (MRI, dementia) and biospecimens (plasma, serum, brain autopsy). As a MarkVCID site, we aim to perform a comprehensive, longitudinal validation of candidate biomarkers of CSVD in a diverse sample. We aim to recruit 400 participants over age 55 years with subjective cognitive complaints, mild cognitive impairment, or early dementia of presumed vascular etiology and retain at least 320 of them over the 5-year follow-up; ~60 will be persons seen in the UH3 phase and will have 7 years of follow- up. We will perform a comprehensive examination to collect medical history, biospecimens (blood, CSF), imaging (MRI with cerebrovascular reactivity, optical coherence tomography angiography), and neuropsychological data (cognition, CDR) following the protocols developed during the UH2/UH3 phases of the MarkVCID consortium. We will perform a follow-up examination with interim phone screenings for cognitive status and continuous dementia surveillance via consensus conferences. Further, we will offer brain autopsies to consenting participants for the assessment of clinicopathological correlates of VCID biomarkers. We will measure selected fluid and imaging biomarkers following established kit protocols and perform longitudinal clinical validation of biomarkers according to their pre-specified hypotheses. Finally, we will perform additional validation in four cohorts of the CHARGE consortium. Data, biospecimens, and results will be shared with the consortium and external qualified investigators through the designated MarkVCID coordinating center. Our team will have strong leadership with the PIs of the UH3 Seshadri, Fornage (multiple PI), Tracy (Co-I), a proven, young Co-I now taking over as Contact PI (Satizabal), and the addition of an exceptional stroke trials leader (Savitz).
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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MYRIAM FORNAGE其他文献
MYRIAM FORNAGE的其他文献
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{{ truncateString('MYRIAM FORNAGE', 18)}}的其他基金
Multiethnic Validation of VCID biomarkers in South Texas
德克萨斯州南部 VCID 生物标志物的多种族验证
- 批准号:
10369339 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Genetics of deep-learning-derived neuroimaging endophenotypes for Alzheimer's Disease
阿尔茨海默病深度学习神经影像内表型的遗传学
- 批准号:
10653800 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Genetics of deep-learning-derived neuroimaging endophenotypes for Alzheimer's Disease
阿尔茨海默病深度学习神经影像内表型的遗传学
- 批准号:
10675679 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Genetics of deep-learning-derived neuroimaging endophenotypes for Alzheimer's Disease (Parent grant)
阿尔茨海默氏病深度学习衍生的神经影像内表型的遗传学(家长资助)
- 批准号:
10827718 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Genetics of deep-learning-derived neuroimaging endophenotypes for Alzheimer's Disease (Parent grant)
阿尔茨海默氏病深度学习衍生的神经影像内表型的遗传学(家长资助)
- 批准号:
10599738 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Genetics of deep-learning-derived neuroimaging endophenotypes for Alzheimer's Disease
阿尔茨海默病深度学习神经影像内表型的遗传学
- 批准号:
10436262 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Genetics of deep-learning-derived neuroimaging endophenotypes for Alzheimer's Disease
阿尔茨海默病深度学习神经影像内表型的遗传学
- 批准号:
10212068 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
CHARGE 联盟中脑小血管疾病的小胶质细胞、炎症和组学标记
- 批准号:
9792270 - 财政年份:2016
- 资助金额:
$ 119.2万 - 项目类别:
Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
CHARGE 联盟中脑小血管疾病的小胶质细胞、炎症和组学标记
- 批准号:
9272153 - 财政年份:2016
- 资助金额:
$ 119.2万 - 项目类别:
ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems
通过内表型、组学对多种族队列进行 ADSP 随访
- 批准号:
9078875 - 财政年份:2016
- 资助金额:
$ 119.2万 - 项目类别:
相似海外基金
Multiethnic Validation of VCID biomarkers in South Texas
德克萨斯州南部 VCID 生物标志物的多种族验证
- 批准号:
10369339 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
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- 批准号:
10611830 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
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肯塔基大学 MarkVCID 生物标志物验证队列:开发推进 VCID 干预研究的工具箱
- 批准号:
10368338 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Validation of Biomarkers of Small Vessel Injury in VCID
VCID 中小血管损伤生物标志物的验证
- 批准号:
10611827 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic Population
多种族人群中影像学和基于血液的小血管 VCID 生物标志物的验证
- 批准号:
10611821 - 财政年份:2021
- 资助金额:
$ 119.2万 - 项目类别:
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic Population
多种族人群中影像学和基于血液的小血管 VCID 生物标志物的验证
- 批准号:
10369505 - 财政年份:2016
- 资助金额:
$ 119.2万 - 项目类别:
Validation of Biomarkers of Small Vessel Injury in VCID
VCID 中小血管损伤生物标志物的验证
- 批准号:
10369502 - 财政年份:2016
- 资助金额:
$ 119.2万 - 项目类别:
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkers
验证小血管对认知障碍和痴呆 (VCID) 生物标志物的贡献
- 批准号:
10611828 - 财政年份:2016
- 资助金额:
$ 119.2万 - 项目类别:
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkers
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10368371 - 财政年份:2016
- 资助金额:
$ 119.2万 - 项目类别:
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkers
验证小血管对认知障碍和痴呆 (VCID) 生物标志物的贡献
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10888591 - 财政年份:2016
- 资助金额:
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