Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkers

项目摘要/摘要 我们在约翰霍普金斯大学的网站是脑血管反应性(CVR)的主要网站。 将在MarkVCID 2研究中得到临床验证的MRI生物标志物试剂盒。CVR MRI需要 由二氧化碳监测仪、气囊、三通阀连接组成的装置 气囊，用于控制吸入和呼出空气的流动的非再呼吸阀，以及 二氧化碳气体输送和采样所需的其他附件。JHU网站将购买这些 组件，以建立一个“启动工具包”，并将它们运往注册网站。这将允许 招生网站开始数据采集。未来更换或订购组件和 供应将由个别地点负责。在这份行政副刊中，我们将 订购这些组件，开发“启动套件”，然后将它们运送到注册网站。

Project Summary/Abstract Our site at Johns Hopkins University is the lead site for the cerebrovascular reactivity(CVR) MRI biomarker kit that will be clinically validated in the MarkVCID 2 Study. CVR MRI requires an apparatus consisting of carbon-dioxide (CO2) monitor, gas bag, three-way valve for connection to the gas bag, non-rebreathing valve for control of the flow of the inhaled and exhaled air, and other accessories needed for CO2 gas delivery and sampling. The JHU site will purchase these components to build a “startup kit”, and will ship them to the enrollment sites. This will allow the enrollment sites to begin the data acquisition. Future replacement or ordering of components and supplies will be the responsibility of the individual site. In this Administrative Supplement, we will order these components, develop the “startup kits”, and ship them to the enrollment sites.