Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkers

验证小血管对认知障碍和痴呆 (VCID) 生物标志物的贡献

• 批准号: 10888591
• 负责人: MARILYN S. ALBERT
• 金额: $ 16.31万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10888591
• 关键词: Administrative Supplement; Air; Biological Markers; Carbon Dioxide; Clinical; Enrollment; Exhalation; Future; Gases; Inhalation; Lead; Lung; Magnetic Resonance Imaging; Monitor; Participant; Procedures; Sampling; Site; Universities; Validation; cerebrovascular; data acquisition; individual responsibility; magnetic resonance imaging biomarker; vascular cognitive impairment and dementia

Project Summary/Abstract Our site at Johns Hopkins University is the lead site for the cerebrovascular reactivity(CVR) MRI biomarker kit that will be clinically validated in the MarkVCID 2 Study. CVR MRI requires an apparatus consisting of carbon-dioxide (CO2) monitor, gas bag, three-way valve for connection to the gas bag, non-rebreathing valve for control of the flow of the inhaled and exhaled air, and other accessories needed for CO2 gas delivery and sampling. The JHU site will purchase these components to build a “startup kit”, and will ship them to the enrollment sites. This will allow the enrollment sites to begin the data acquisition. Future replacement or ordering of components and supplies will be the responsibility of the individual site. In this Administrative Supplement, we will order these components, develop the “startup kits”, and ship them to the enrollment sites.

项目概要/摘要 我们位于约翰霍普金斯大学的站点是脑血管反应性 (CVR) 的主要站点 MRI 生物标志物套件将在 MarkVCID 2 研究中进行临床验证。 CVR MRI 需要 装置由二氧化碳 (CO2) 监测仪、气囊、连接用三通阀组成 至气囊、用于控制吸入和呼出空气流量的非再呼吸阀，以及 CO2 气体输送和采样所需的其他附件。 JHU 网站将购买这些 组件来构建“启动套件”，并将其运送到报名地点。这将允许 注册站点开始数据采集。未来更换或订购组件和 供应将由各个站点负责。在本行政补充文件中，我们将 订购这些组件，开发“启动套件”，并将其运送到报名地点。