Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkers

项目概要/摘要 我们在约翰霍普金斯大学的研究中心是脑血管反应性（CVR）的主要研究中心。 将在MarkVCID 2研究中进行临床验证的MRI生物标志物试剂盒。CVR MRI需要 由二氧化碳（CO 2）监测器、气囊、三通阀连接组成的装置 至气囊，用于控制吸入和呼出空气的流动的非再呼吸阀，以及 CO2气体输送和取样所需的其他附件。JHU网站将购买这些 组件来构建“启动工具包”，并将它们运送到注册站点。这将允许 入组研究中心开始数据采集。未来更换或订购组件， 供应将由各研究中心负责。在本行政补充文件中，我们将 订购这些组件，开发“启动工具包”，并将其运送到注册站点。

Project Summary/Abstract Our site at Johns Hopkins University is the lead site for the cerebrovascular reactivity(CVR) MRI biomarker kit that will be clinically validated in the MarkVCID 2 Study. CVR MRI requires an apparatus consisting of carbon-dioxide (CO2) monitor, gas bag, three-way valve for connection to the gas bag, non-rebreathing valve for control of the flow of the inhaled and exhaled air, and other accessories needed for CO2 gas delivery and sampling. The JHU site will purchase these components to build a “startup kit”, and will ship them to the enrollment sites. This will allow the enrollment sites to begin the data acquisition. Future replacement or ordering of components and supplies will be the responsibility of the individual site. In this Administrative Supplement, we will order these components, develop the “startup kits”, and ship them to the enrollment sites.