GlyCORE: Glycoscience Center of Research Excellence

项目概要/摘要 密西西比大学提议建立糖科学卓越研究中心 （GlyCORE），生物医学研究卓越的第一阶段中心。糖科学是一个必不可少的和快速的 生物医学科学的新兴领域，以及糖科学研究的挑战性，需要工具和 这在生物医学研究领域并不常见。此外，生物医学 社区正在迅速发展，以了解碳水化合物的重要作用，与研究人员以外的 自我认定的“糖科学”社区发现自己面临着解决具有挑战性的问题， 将糖科学作为其生物医学研究人员课程的一部分。GlyCORE将开发并提供 为核心糖科学研究人员以及 在他们的生物医学研究项目过程中遇到糖科学的问题。GlyCORE将服务于 密西西比大学和中南部社区的研究人员通过三种机制：一 教师发展计划，建立三个研究中心，以支持糖科学研究， 以及建立以糖科学问题为重点的地方和区域会议。GlyCORE的 教师发展计划包括四个初级研究员的支持， 糖科学中的各种学科。该计划包括对调查人员研究的财政支持 努力，一个正式的辅导计划，并优先资助进入密西西比大学的核心设施。 GlyCORE还将通过试点项目计划支持较小的发展项目，包括金融 支持并优先利用核心设施。GlyCORE的教师发展计划也将促进 招聘糖科学教师的密西西比大学，包括招聘职业生涯中期 碳水化合物合成化学家，以帮助支持扩大服务GlyCORE在第二阶段。GlyCORE的 研究核心将在密西西比大学建立三个新的核心能力， 现代糖科学：支持高分辨率色谱的分析和生物物理核心， 质谱分析;成像核心支持共聚焦显微镜与凝集素为基础的和抗- 碳水化合物免疫组织化学成像;以及计算和生物信息学核心支持 模拟和生物信息学数据分析，以支持糖科学和结构糖生物学。最后， GlyCORE将建立密西西比大学作为中南部糖科学的区域中心。 GlyCORE将主办一年一度的中南糖科学会议，并为区域参与者提供补贴， 并将举办年度UM糖科学研讨会和每月糖科学会议，以突出 密西西比大学的糖科学的作用。总之，这些努力将建立一个经验丰富的核心， 在现代研究基础设施的支持下， 作为中南部的糖科学目的地，被推广到糖科学社区。

Project Summary/Abstract The University of Mississippi proposes to establish the Glycoscience Center of Research Excellence (GlyCORE), a Phase I Center of Biomedical Research Excellence. Glycoscience is an essential and rapidly emerging field of biomedical science, and the challenging nature of glycoscience research requires tools and expertise that are not commonly found in the biomedical research community. Moreover, the biomedical community is rapidly growing to appreciate the essential role of carbohydrates, with researchers outside of the self-identified “glycoscience” community finding themselves faced with addressing challenging questions in glycoscience as part of the course of their biomedical researchers. GlyCORE will develop and provide resources and expertise in glycoscience to both core glycoscience researchers as well as researchers who encounter questions in glycoscience in the course of their biomedical research programs. GlyCORE will serve researchers at both the University of Mississippi and the Mid-South community through three mechanisms: a Faculty Development program, the establishment of three Research Cores to support glycoscience research, and the establishment of local and regional meetings focusing on questions in glycoscience. GlyCORE's Faculty Development program includes the support of four Junior Investigators establishing their careers in various disciplines in glycoscience. This program includes financial support of the investigators' research efforts, a formal mentoring program, and priority subsidized access to University of Mississippi core facilities. GlyCORE will also support smaller developmental projects through a Pilot Project Program, including financial support and prioritized access to core facilities. GlyCORE's Faculty Development program will also promote recruitment of glycoscience faculty to the University of Mississippi, including the recruitment of a mid-career carbohydrate synthetic chemist to help support expanded services in GlyCORE during Phase II. GlyCORE's Research Cores will establish three new core capabilities at the University of Mississippi that are essential for modern glycoscience: an Analytical and Biophysical Core supporting high resolution chromatography and mass spectrometry analyses; an Imaging Core supporting confocal microscopy with lectin-based and anti- carbohydrate immunohistochemistry imaging; and a Computational and Bioinformatics Core supporting simulations and bioinformatics data analysis to support glycoscience and structural glycobiology. Finally, GlyCORE will establish the University of Mississippi as a regional center for glycoscience in the Mid-South. GlyCORE will host an annual Mid-South Glycoscience Meeting with subsidized access to regional participants, and will host both an annual UM Glycoscience Symposium and monthly glycoscience meetings to highlight the role of glycoscience at the University of Mississippi. Together, these efforts will establish a core of experienced and nationally competitive young faculty in glycoscience, supported by modern research infrastructure and promoted to the glycoscience community as the glycoscience destination in the Mid-South.