GlyCORE: Glycoscience Center of Research Excellence

项目摘要/摘要 密西西比大学提议建立血糖科学卓越研究中心 (GlyCORE)，一期生物医学研究卓越中心。血糖科学是一种基本的、快速的 生物医学的新兴领域，而糖科学研究的挑战性需要工具和 在生物医学研究界中不常见的专业知识。此外，生物医学 社区正在迅速发展，认识到碳水化合物的基本作用，研究人员在 自我认同的“糖科学”社区发现自己面临着解决挑战性问题 作为他们生物医学研究人员课程的一部分。GlyCORE将开发和提供 向核心糖科学研究人员以及 在他们的生物医学研究计划过程中遇到糖科学方面的问题。Glycore将为您提供 密西西比大学和中南社区的研究人员通过三种机制：a 教师发展计划，建立三个研究中心以支持糖科学研究， 以及建立地方和区域会议，重点讨论糖科学问题。Glycore‘s 教师发展计划包括支持四名初级调查人员建立他们的职业生涯 糖科学的不同学科。该计划包括对研究人员研究的财政支持 努力，一个正式的指导计划，以及优先补贴进入密西西比大学的核心设施。 GlyCORE还将通过试点项目计划支持较小的发展项目，包括财务 支持核心设施的使用并将其列为优先事项。GlyCORE的教师发展计划也将促进 为密西西比大学招聘糖科学教员，包括职业生涯中期的招聘 碳水化合物合成化学家在第二阶段帮助支持GlyCORE的扩展服务。 研究核心将在密西西比大学建立三个新的核心能力，这三个能力对于 现代糖科学：支持高分辨率层析和分析的生物物理核心 质谱学分析；支持基于凝集素和抗凝集素的共聚焦显微镜的成像核心 碳水化合物免疫组织化学成像；以及计算和生物信息学核心支持 模拟和生物信息学数据分析，以支持糖科学和结构糖生物学。最后， GlyCORE将建立密西西比大学，作为中南部地区的糖科学中心。 GlyCORE将主办一年一度的中南糖科学会议，向区域与会者提供补贴， 并将主办UM血糖科学年度研讨会和每月血糖科学会议，以突出 密西西比大学血糖科学的作用。综合起来，这些努力将建立一个经验丰富的核心 和在糖科学领域具有全国竞争力的年轻教员，得到现代研究基础设施和 推广到糖科学社区，成为中南部的糖学目的地。

Project Summary/Abstract The University of Mississippi proposes to establish the Glycoscience Center of Research Excellence (GlyCORE), a Phase I Center of Biomedical Research Excellence. Glycoscience is an essential and rapidly emerging field of biomedical science, and the challenging nature of glycoscience research requires tools and expertise that are not commonly found in the biomedical research community. Moreover, the biomedical community is rapidly growing to appreciate the essential role of carbohydrates, with researchers outside of the self-identified “glycoscience” community finding themselves faced with addressing challenging questions in glycoscience as part of the course of their biomedical researchers. GlyCORE will develop and provide resources and expertise in glycoscience to both core glycoscience researchers as well as researchers who encounter questions in glycoscience in the course of their biomedical research programs. GlyCORE will serve researchers at both the University of Mississippi and the Mid-South community through three mechanisms: a Faculty Development program, the establishment of three Research Cores to support glycoscience research, and the establishment of local and regional meetings focusing on questions in glycoscience. GlyCORE's Faculty Development program includes the support of four Junior Investigators establishing their careers in various disciplines in glycoscience. This program includes financial support of the investigators' research efforts, a formal mentoring program, and priority subsidized access to University of Mississippi core facilities. GlyCORE will also support smaller developmental projects through a Pilot Project Program, including financial support and prioritized access to core facilities. GlyCORE's Faculty Development program will also promote recruitment of glycoscience faculty to the University of Mississippi, including the recruitment of a mid-career carbohydrate synthetic chemist to help support expanded services in GlyCORE during Phase II. GlyCORE's Research Cores will establish three new core capabilities at the University of Mississippi that are essential for modern glycoscience: an Analytical and Biophysical Core supporting high resolution chromatography and mass spectrometry analyses; an Imaging Core supporting confocal microscopy with lectin-based and anti- carbohydrate immunohistochemistry imaging; and a Computational and Bioinformatics Core supporting simulations and bioinformatics data analysis to support glycoscience and structural glycobiology. Finally, GlyCORE will establish the University of Mississippi as a regional center for glycoscience in the Mid-South. GlyCORE will host an annual Mid-South Glycoscience Meeting with subsidized access to regional participants, and will host both an annual UM Glycoscience Symposium and monthly glycoscience meetings to highlight the role of glycoscience at the University of Mississippi. Together, these efforts will establish a core of experienced and nationally competitive young faculty in glycoscience, supported by modern research infrastructure and promoted to the glycoscience community as the glycoscience destination in the Mid-South.