P 3: PSYCHOACTIVITY OF CANNABINOIDS & INTERACTIO W/ DELTA-9-TETRAHYDROCANNABINOL

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 该项目的具体目标如下： 1. 分离和结构分析不同的大麻素，特别是来自大麻提取物的多羟基化大麻三酚组和非大麻素酚类化合物，其生物活性未知。 2. 确认分离化合物的作用机制涉及与内源性大麻素系统的相互作用。 3. 研究分离化合物的精神活性，并将其与δ-9-THC进行比较。 4. 研究Delta-9-THC与单个分离化合物的相互作用，并确定它们对大麻整体生物活性的贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this project are as follows: 1. Isolate and structurally analyze different cannabinoids, especially from the polyhydroxylated cannabitriol group and non-cannabinoid phenolic compounds from cannabis extract, whose biological activity is unknown. 2. Confirm that the mechanism of action of the isolated compounds involves an interaction with the endogenous cannabinoid system. 3. Study the psychoactivity of the isolated compounds and compare it with that of delta-9-THC. 4. Study the interaction of delta-9-THC with the individual isolated compounds and determine their contribution to the overall biological activities of cannabis.