P 3: PSYCHOACTIVITY OF CANNABINOIDS & INTERACTIO W/ DELTA-9-TETRAHYDROCANNABINOL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的具体目标如下： 1.对不同的大麻素类化合物进行分离和结构分析，特别是从大麻提取物中分离出活性未知的多羟基大麻三醇基和非大麻素性酚类化合物。 2.确认分离化合物的作用机制涉及与内源性大麻素系统的相互作用。 3.对分离得到的化合物进行心理活性研究，并与β-9-THC进行比较。 4.研究Delta-9-THC与个别分离化合物的相互作用，并确定它们对大麻整体生物活性的贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this project are as follows: 1. Isolate and structurally analyze different cannabinoids, especially from the polyhydroxylated cannabitriol group and non-cannabinoid phenolic compounds from cannabis extract, whose biological activity is unknown. 2. Confirm that the mechanism of action of the isolated compounds involves an interaction with the endogenous cannabinoid system. 3. Study the psychoactivity of the isolated compounds and compare it with that of delta-9-THC. 4. Study the interaction of delta-9-THC with the individual isolated compounds and determine their contribution to the overall biological activities of cannabis.