Component for Institution # 269291

摘要 目前的HIV-1大流行是一种艾滋病毒携带者(PWH)感染受到很好抑制的情况 长时间的治疗。这引导了研究转向关注(I)合并症(衰老， 心血管、癌症、代谢和免疫激活)，(Ii)抗逆转录病毒治疗的副作用，(Iii)神经认知和 行为障碍(约40%的时间发生)、(4)社会经济不平等、耻辱和 歧视、性别和性别差异、人际关系和神经心理问题，包括 (V)新的治疗方法和治疗策略。的研究进展 这些不同的领域需要跨学科的方法，调查人员参与基础、行为、 和临床研究。为此，发展研究和指导核心的总体目标 (DRMC)将为神经艾滋病毒和艾滋病的创新试点项目提供支持。针对新兴艾滋病毒的研究 科学优先事项和对下一代艾滋病毒研究人员的指导。DRMC将提供 为试点调查、进展评估、指导和指导提供基础设施和支持。此核心 申请书介绍了当前资助期的进展、核心董事的经验、 招聘和审查创新项目申请的流程，以及核心将在指导 临床和基础科学教职员工和各级实习生。在过去五年(六至十年)，19(5由 (成本分摊)奖主要颁发给初级调查人员。飞行员奖金的获得者非常 成功地出版了31份手稿，并从与最近的试点赠款有关的研究中获得了9笔赠款。 在接下来的5年里，DRMC将每年资助6项试点申请。其中两个将由该基金提供资金。DRMC 和四个来自机构的支持，以提供更优化的试点项目方案，并扩大我们的努力 加强对代表不足少数群体(URM)研究人员的招聘和发展。使用 在辅导方面，短期目标是协助初级、较资深的新接触爱滋病病毒的教师，以及URM教师。 在制定一项成功的试点研究基金提案方面。长期目标将是提供培训和 对获奖者的指导，将促进和加强他们未来在神经艾滋病毒方面的职业生涯。DRMC将 提供一个组织和结构，有效地整合新项目的开发、资金和 初步研究、指导和建立新的跨学科合作。DRMC将会工作 与中央行政管理核心(CAMC)和科学核心密切合作，推动高质量 CNHC的研究重点和总体目标。预计这一核心将发挥关键作用。 在加强和确保神经艾滋病毒调查人员取得成功方面，扩大URM的外展和支持，以及 推进神经艾滋病毒研究和执行CNHC任务。

SUMMARY The current HIV-1 pandemic is one where people living with HIV (PWH) have had well-suppressed infection with therapy for prolonged periods of time. This has guided research towards focusing on (i) comorbidities (aging, cardiovascular, cancer, metabolic, and immune activation), (ii) side effects of ART, (iii) neurocognitive and behavioral disorders (occurs approximately 40% of time), (iv) socioeconomic inequalities, stigma and discrimination, sexual and gender disparities, interpersonal relations, and neuropsychological problems including depression across the PWH community, and (v) new therapeutics and cure strategies. Research advances in these diverse areas require an interdisciplinary approach with participation of investigators in basic, behavioral, and clinical research. Toward this end, the overall aim of the Developmental Research and Mentorship Core (DRMC) is to provide support for innovative pilot projects in neuroHIV and. HIV research addressing emerging scientific priorities and mentorship of the next generation of HIV researchers. The DRMC will provide infrastructure and support for pilot investigations, progress evaluation, guidance, and mentorship. This Core application describes the progress during the current funding period, experience of the Core Directors, the process to recruit and review innovative project applications, and the role the Core will play in mentorship of clinical and basic science faculty and trainees at various levels. In the last five years (years 6-10), 19 (5 from cost share) awards were given mostly to junior investigators. Awardees of pilot monies have been extremely successful with 31 published manuscripts and 9 grants awarded from research related to the recent pilot grants. Over the next 5-year period, the DRMC will fund six pilot applications per year. Two will be funded by the. DRMC and four from institutional support to provide a more optimal pilot project program and to expand our efforts to enhance the recruitment and development of underrepresented minority (URM) research investigators. With regards to mentorship, the short-term goal is to assist junior, more senior faculty new to HIV, and URM faculty in developing a successful proposal for pilot study funds. The long-term goal will be to provide training and mentorship to awardees that will foster and strengthen their careers in neuroHIV into the future. The DRMC will provide an organization and structure that will effectively integrate new project development, funding of preliminary research, mentorship and establishing new interdisciplinary collaborations. The DRMC will work closely with the Central Adminstrative and Management Core (CAMC) and scientific cores to promote high research priorities and overarching objectives of the CNHC. It is anticipated that this core will play a pivotal role in enhancing and ensuring the success of neuroHIV investigators, expand outreach and support of URM, and advance neuroHIV research and execution of the CNHC mission.