Violence and onward HIV transmission in perinatally-infected adolescents
围产期感染青少年的暴力和艾滋病毒传播
基本信息
- 批准号:10613991
- 负责人:
- 金额:$ 57.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-15 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AdherenceAdolescenceAdolescentAdultAffectBehaviorBehavioralCellular PhoneChildhoodClinicCommunitiesDataDevelopmentDomestic ViolenceEcological momentary assessmentEnrollmentEpidemicEquationExposure toFamilyFrequenciesGenderHIVHIV SeronegativityHIV SeropositivityHIV-infected adolescentsHomeIncomeIndividualInterventionInterviewLife Cycle StagesLinkLongitudinal SurveysMale AdolescentsMeasuresMediatorMedicalMental DepressionModelingOutcomeParticipantPerinatalPerinatal transmissionPopulationPreventionRecommendationReportingResearchRiskRisk BehaviorsSexual HealthSexual abuseSouth AfricaSurveysTestingTimeUnsafe SexVictimizationViolenceViralViral Load resultagedboyscondomsdesignearly life adversityexperiencefollow-upgirlshigh risk behaviorhigh risk sexual behaviorintimate partner violencemalemenpeerperinatal HIVphysical abusepreventtransmission processtreatment adherenceviolence exposureviolence perpetrationviolence victimization
项目摘要
Project Summary (30 lines)
Over two million adolescents are infected with HIV globally, the majority due to perinatal
transmission. As HIV-positive adolescents, their choices – such as inconsistent medical
adherence and unprotected sex - have the potential to alter the HIV epidemic. South Africa,
home to the largest population of HIV-infected adolescents, is also experiencing a second
epidemic of violence. Together, these epidemics create a devastating cycle. Intimate partner
violence (IPV) is widely viewed as a key driver of HIV transmission, but is only part of the story.
Violence victimization (at home, in relationships, and in the community) may similarly increase
behavioral risk. To better understand how violence influences HIV transmission risk, we will
enroll 300 HIV-positive and 300 HIV-negative male adolescents (aged 15-19) in Soweto, South
Africa. At baseline and follow-up, participants will complete comprehensive surveys and medical
testing (STIs, viral load). During the observation year, they will complete bi-weekly mobile phone
surveys, yielding ecological momentary assessment (EMA) data on how daily experiences of
violence affect behaviors in real time. In-depth interviews will be used to help us to better-
understand how these behaviors are enacted by adolescents in their day-to-day lives. The aims
are as follows: Aim 1: To measure IPV perpetration by PHIV, and test whether it exceeds
that of HIV-negative peers. Most interventions to prevent IPV focus on girls only, but boys are
increasingly recognized as essential participants. In urban South Africa, up to 40% of
adolescent boys report perpetrating physical or sexual IPV. There is no data on IPV perpetration
by male PHIV – the population with the greatest potential to transmit HIV during adolescence..
Aim 2: To estimate the impact of violence victimization on behaviors associated with
onward HIV transmission in both PHIV and HIV-negative peers. Exposure to violence may
heighten risk of onward transmission by 1) decreasing HIV treatment adherence necessary for
viral suppression, 2) decreasing condom use, and 3) increasing perpetration of IPV. Using
longitudinal data and EMA, we will be able to establish temporal order between violence
victimization and these three outcomes. Aim 3: To highlight potential intervention points by
identifying the most salient mediators linking violence to HIV transmission behaviors. We
will use structural equation modelling to test potential mediators (e.g., depression, gender
ideology) between multi-level violence and behavioral risk. Combined with the above aims, this
body of evidence will guide us towards effective, developmentally-appropriate interventions that
prevent onward HIV transmission.
项目摘要(30行)
全球有200多万青少年感染艾滋病毒,其中大多数是由于围产期感染。
传输作为艾滋病毒呈阳性的青少年,他们的选择-例如不一致的医疗保健-
坚持和无保护的性行为-有可能改变艾滋病毒的流行。南非,
作为艾滋病毒感染青少年人口最多的国家,
暴力的流行。这些流行病一起造成了一个毁灭性的循环。亲密伴侣
暴力(IPV)被广泛认为是艾滋病毒传播的一个关键驱动因素,但这只是故事的一部分。
暴力受害(在家庭、人际关系和社区中)也可能同样增加
行为风险为了更好地了解暴力如何影响艾滋病毒传播风险,我们将
在南部索韦托招募300名艾滋病毒阳性和300名艾滋病毒阴性男性青少年(15-19岁)
非洲在基线和随访时,参与者将完成全面的调查和医疗检查
检测(性病,病毒载量)。在观察年期间,他们将完成每两周一次的移动的电话
调查,产生生态瞬时评估(EMA)数据,了解
暴力会在真实的时间里影响行为。深入访谈将帮助我们更好地-
了解青少年在日常生活中如何实施这些行为。目标
目的1:测量PHIV的IPV犯罪,并测试它是否超过
艾滋病毒阴性的同龄人。大多数预防IPV的干预措施只关注女孩,但男孩
越来越多地被认为是重要的参与者。在南非城市,
据报告,青少年男孩实施了身体或性IPV。没有关于IPV犯罪的数据
男性PHIV -最有可能在青春期传播艾滋病毒的人群。
目的2:评估暴力受害对与下列行为相关的行为的影响:
在PHIV和HIV阴性的同伴中继续传播HIV。暴露于暴力可能
1)减少艾滋病毒治疗依从性,
病毒抑制,2)减少避孕套的使用,3)增加IPV的犯罪。使用
纵向数据和EMA,我们将能够建立暴力之间的时间顺序
受害和这三种结果。目标3:突出潜在的干预点,
确定将暴力与艾滋病毒传播行为联系起来的最突出的媒介。我们
将使用结构方程模型来测试潜在的介质(例如,抑郁症,性别
意识形态)之间的多层次暴力和行为风险。结合上述目标,
大量证据将指导我们采取有效的、适合发展的干预措施,
预防艾滋病毒的进一步传播。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Implementing ecological momentary assessments to measure violence and adolescent HIV transmission risk: Lessons from Johannesburg, South Africa.
- DOI:10.1371/journal.pdig.0000283
- 发表时间:2024-02
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Rachel Kidman其他文献
Rachel Kidman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Rachel Kidman', 18)}}的其他基金
Violence and onward HIV transmission in perinatally-infected adolescents
围产期感染青少年的暴力和艾滋病毒传播
- 批准号:
10428472 - 财政年份:2019
- 资助金额:
$ 57.62万 - 项目类别:
Violence and onward HIV transmission in perinatally-infected adolescents
围产期感染青少年的暴力和艾滋病毒传播
- 批准号:
10153887 - 财政年份:2019
- 资助金额:
$ 57.62万 - 项目类别:
Adverse childhood experiences and adolescent HIV risk: Causal inferences from a high HIV prevalence context
不良童年经历和青少年艾滋病毒风险:艾滋病毒高流行背景下的因果推论
- 批准号:
9963293 - 财政年份:2016
- 资助金额:
$ 57.62万 - 项目类别:
Adverse childhood experiences and adolescent HIV risk: Causal inferences from a high HIV prevalence context
不良童年经历和青少年艾滋病毒风险:艾滋病毒高流行背景下的因果推论
- 批准号:
9359991 - 财政年份:2016
- 资助金额:
$ 57.62万 - 项目类别:
Adverse childhood experiences and adolescent HIV risk: Causal inferences from a high HIV prevalence context
不良童年经历和青少年艾滋病毒风险:艾滋病毒高流行背景下的因果推论
- 批准号:
9270751 - 财政年份:2016
- 资助金额:
$ 57.62万 - 项目类别:
Pathways to Sexual Health among Adolescent Orphans across sub-Saharan Africa
撒哈拉以南非洲地区青少年孤儿的性健康之路
- 批准号:
9121608 - 财政年份:2015
- 资助金额:
$ 57.62万 - 项目类别:
相似海外基金
Identification of Prospective Predictors of Alcohol Initiation During Early Adolescence
青春期早期饮酒的前瞻性预测因素的鉴定
- 批准号:
10823917 - 财政年份:2024
- 资助金额:
$ 57.62万 - 项目类别:
Socio-Emotional Characteristics in Early Childhood and Offending Behaviour in Adolescence
幼儿期的社会情感特征和青春期的犯罪行为
- 批准号:
ES/Z502601/1 - 财政年份:2024
- 资助金额:
$ 57.62万 - 项目类别:
Fellowship
Cognitive and non-cognitive abilities and career development during adolescence and adult development: from the perspective of genetic and environmental structure
青春期和成人发展期间的认知和非认知能力与职业发展:从遗传和环境结构的角度
- 批准号:
23K02900 - 财政年份:2023
- 资助金额:
$ 57.62万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Reasoning about Spatial Relations and Distributions: Supporting STEM Learning in Early Adolescence
空间关系和分布的推理:支持青春期早期的 STEM 学习
- 批准号:
2300937 - 财政年份:2023
- 资助金额:
$ 57.62万 - 项目类别:
Continuing Grant
Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors
青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响
- 批准号:
10785373 - 财政年份:2023
- 资助金额:
$ 57.62万 - 项目类别:
Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the Lifespan
绘制青春期和整个生命周期饮酒的神经生物学风险和后果
- 批准号:
10733406 - 财政年份:2023
- 资助金额:
$ 57.62万 - 项目类别:
The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence
睡眠在不良童年经历、心理健康症状和青春期持续/复发性疼痛之间关系中的作用
- 批准号:
10676403 - 财政年份:2023
- 资助金额:
$ 57.62万 - 项目类别:
Thalamo-prefrontal circuit maturation during adolescence
丘脑-前额叶回路在青春期成熟
- 批准号:
10585031 - 财政年份:2023
- 资助金额:
$ 57.62万 - 项目类别:
Interdisciplinary Perspectives on the Politics of Adolescence and Democracy
青少年政治与民主的跨学科视角
- 批准号:
EP/X026825/1 - 财政年份:2023
- 资助金额:
$ 57.62万 - 项目类别:
Research Grant
An Empirical Study on the Influence of Socioeconomic Status in Adolescence on Exercise Habits in Adulthood
青春期社会经济地位对成年期运动习惯影响的实证研究
- 批准号:
23K16734 - 财政年份:2023
- 资助金额:
$ 57.62万 - 项目类别:
Grant-in-Aid for Early-Career Scientists