Research Supplement to Promote Diversity: Carlos Torres (R03EB031495 Parent Award)

促进多样性的研究补充:Carlos Torres(R03EB031495 家长奖)

基本信息

  • 批准号:
    10592146
  • 负责人:
  • 金额:
    $ 1.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-06-01 至 2022-12-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Every year an estimated 19.4 million children do not receive the set of vaccines recommended by the World Health Organization, leading to 1.5 million vaccine-preventable deaths.1,2 A majority of undervaccinated children live in low- and middle-income countries and often have limited access to healthcare.2,3 Nearly 6 million of these children receive at least one vaccine dose, but remain at risk because they have not completed the full dosing regimen.4,5 A vaccination method that delivers all doses of a vaccine, or multiple vaccines, in a single injection would enable children with even one-time access to healthcare to be fully protected from the corresponding infectious disease. Unfortunately, most controlled-release drug delivery systems exhibit continuous release kinetics, which is vastly different from traditional soluble vaccines administered in multiple discrete doses over a course of months. One recent study has described the development of biodegradable microparticle platform with a polymer shell encapsulating a vaccine-loaded core that exhibits delayed, pulsatile release after a period determined by the polymer degradation rate.6 By injecting patients with a mixed population of particles with different degradation rates, vaccine can be released as discrete pulses, thereby mimicking traditional vaccination schedules known to be safe and effective. Unfortunately, the original microparticle production method negatively affects antigen stability, requires the use of large-gauge needles, and is low-throughput. This project seeks to overcome these challenges by preparing microparticles using coaxial electrospraying, a single-step fabrication process that can produce a single aqueous, vaccine-loaded core surrounded by a shell of polymer. The parent proposal first aims to create small core-shell microparticles with dense polymeric shells that demonstrate the delayed, pulsatile release of macromolecules in vitro and in vivo using fluorescently-labeled model molecules and reporter proteins to assess protein stability within the microparticles. This diversity supplement will expand the scope of work previously proposed to support the work of Carlos Torres, a Hispanic male undergraduate student at Houston Community College, including the investigation of coaxial electrospraying parameters between pieces of electrospraying equipment. The goal of Carlos’s work is to identify the key features that affect core-shell microparticle morphology and release kinetics and develop solutions that allows electrospraying conditions to be readily transferred between different pieces of equipment. If successful, Carlos’s work will enhance the reproducibility of science and allow different research groups to work in unison to improve electrosprayed particle formulations for single-injection vaccination as well as other drug delivery applications. Ultimately, these particles could serve as a key tool in the fight against infectious disease both in the developing world where resources are limited and in the developed world, where uninsured children and rural communities show consistently lower vaccination coverage.7
项目总结/文摘

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Translating diagnostics and drug delivery technologies to low-resource settings.
Novel Vaccine Adjuvants as Key Tools for Improving Pandemic Preparedness.
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Kevin James McHugh其他文献

Kevin James McHugh的其他文献

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{{ truncateString('Kevin James McHugh', 18)}}的其他基金

Research Supplement to Promote Diversity: Belvi Bwela (R03EB031495 Parent Award)
促进多样性的研究补充:Belvi Bwela(R03EB031495 家长奖)
  • 批准号:
    10592142
  • 财政年份:
    2022
  • 资助金额:
    $ 1.5万
  • 项目类别:
Electrosprayed Core-Shell Microparticles as a Pulsatile Vaccine Delivery Platform
电喷雾核壳微粒作为脉冲疫苗输送平台
  • 批准号:
    10195135
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Solvent Evaporator Equipment Supplement to R35GM143101
R35GM143101 溶剂蒸发器设备补充
  • 批准号:
    10799251
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Next-Generation Parenteral Drug Delivery Systems for Controlling Pharmacokinetics
用于控制药代动力学的下一代肠外给药系统
  • 批准号:
    10277139
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Electrosprayed Core-Shell Microparticles as a Pulsatile Vaccine Delivery Platform
电喷雾核壳微粒作为脉冲疫苗输送平台
  • 批准号:
    10372138
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Next-Generation Parenteral Drug Delivery Systems for Controlling Pharmacokinetics
用于控制药代动力学的下一代肠外给药系统
  • 批准号:
    10890222
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Research Supplement to Promote Diversity: Mei-Li Laracuente (1R35GM143101 Parent Award)
促进多样性的研究补充:Mei-Li Laracuente(1R35GM143101家长奖)
  • 批准号:
    10631614
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Next-Generation Parenteral Drug Delivery Systems for Controlling Pharmacokinetics
用于控制药代动力学的下一代肠外给药系统
  • 批准号:
    10667652
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Next-Generation Parenteral Drug Delivery Systems for Controlling Pharmacokinetics
用于控制药代动力学的下一代肠外给药系统
  • 批准号:
    10488240
  • 财政年份:
    2021
  • 资助金额:
    $ 1.5万
  • 项目类别:
Biomaterial Strategies for Modulating the Immune Response
调节免疫反应的生物材料策略
  • 批准号:
    10232052
  • 财政年份:
    2020
  • 资助金额:
    $ 1.5万
  • 项目类别:

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