Interdepartmental Training in Pharmacological Sciences

药理学科学跨部门培训

• 批准号: 10616678
• 负责人: Lori L. Isom
• 金额: $ 63.66万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10616678
• 关键词: Science; Training; pharmacologic

This new application requests support for the newly re-designed University of Michigan (U-M) Pharmacological Sciences Training Program (PSTP). The goal of the PSTP is to develop a diverse pool of well-trained biomedical scientists who have the technical, operational and professional skills to conduct pharmacological research in an ethically responsible and rigorous manner, and to enter diverse careers in the biomedical research workforce. Annual support for 12 trainees (6-Year 2 and 6-Year 3 Trainees in any one year) is requested throughout the five years of funding. The U-M PSTP is a long-standing collaboration between the Medical School and the College of Pharmacy that provides synergistic, translational education, research training, and career development for pre-doctoral trainees in four degree-granting programs: Pharmacology, Biological Chemistry, Medicinal Chemistry, and Pharmaceutical Sciences. The new, competency-based PSTP curriculum, which includes an experiential program in Real-World Drug Discovery, is designed to provide trainees with a strong foundational understanding of the pharmacological sciences, to provide training in the performance of rigorous and reproducible research, and to provide career development, teamwork, and leadership training, all under the direction of well-trained and dedicated faculty mentors. An extensive and successful alumni base provides career mentorship, networking, and future employment opportunities. PSTP mentors encourage trainees to think broadly about research problems in human disease while focusing their thesis research on a critical, unmet gap in knowledge using rigorous experimental design and methods. This re-designed strong, interdisciplinary, yet individualized, training in the pharmacological sciences will give trainees a distinct advantage in that they will be rapidly employable and well positioned to contribute to the NIH mission to discover new medicines. The development of novel and effective therapeutic agents is a critical, on-going global need that requires rigorously trained, innovative team players to solve critical problems in health care. It is essential that the US continue to produce doctoral-level scientists from diverse backgrounds with broad training in pharmacological sciences and experimental therapeutics who understand basic science and translational medicine. U-M is a premiere institution in research and training of graduate students in the biomedical sciences on a global scale. Although U-M has individual graduate programs in the Departments associated with this training program, the PSTP is the only program at U-M that draws upon the expertise of faculty, alumni, the Michigan Drug Discovery Institute, and the enthusiasm of students across these units to fertilize interdisciplinary education, collaborative research, career development, and team-based approaches to innovation and translation in target discovery and development of experimental therapeutics.

这个新的应用程序要求支持新重新设计的密歇根大学（U-M）药理学 科学培训计划（PSTP）。PSTP的目标是开发一个多样化的训练有素的生物医学人才库， 具有技术、操作和专业技能的科学家在一个国家进行药理学研究， 道德上负责和严谨的态度，并进入生物医学研究的各种职业生涯 劳动力要求每年支持12名学员（任何一年6名2年级和6名3年级学员） 在五年的融资过程中。U-M PSTP是医学院与 和药学院，提供协同，转化教育，研究培训和职业生涯 在四个学位授予课程博士前学员的发展：药理学，生物化学， 药物化学和药物科学。新的，基于能力的PSTP课程， 包括一个真实世界药物发现的体验计划，旨在为学员提供一个强大的 药理学的基础知识，提供严格的性能培训， 和可复制的研究，并提供职业发展，团队合作和领导力培训，所有这些都在 训练有素和敬业的教师导师的方向。一个广泛和成功的校友基地提供 职业指导，网络和未来的就业机会。PSTP导师鼓励学员思考 广泛关注人类疾病的研究问题，同时将论文研究集中在一个关键的，未满足的差距上 使用严格的实验设计和方法。这个重新设计的强大的，跨学科的，但 个性化的，在药理学的培训将给学员一个明显的优势，因为他们将 快速就业和良好的定位，以促进国家卫生研究院的使命，发现新的药物。的 开发新的和有效的治疗剂是一个关键的、持续的全球需求， 训练有素的，创新的团队成员，以解决医疗保健的关键问题。美国必须继续 培养来自不同背景的博士级科学家，他们在药理学方面接受过广泛的培训， 了解基础科学和转化医学的实验治疗学专家。U-M是一个首映式 在全球范围内研究和培训生物医学研究生的机构。虽然 U-M在与此培训计划相关的部门中有单独的研究生课程，PSTP是 密歇根大学唯一一个利用教师，校友，密歇根药物发现研究所， 以及这些单位的学生的热情，以促进跨学科教育，合作研究， 职业发展，以及以团队为基础的方法，以创新和翻译为目标的发现和 实验疗法的发展。

项目成果

Antiplatelet strategies: past, present, and future.

• DOI: 10.1016/j.jtha.2023.09.013
• 发表时间: 2023-12
• 期刊: Journal of thrombosis and haemostasis : JTH
• 作者: L. Stanger;Adriana Yamaguchi;M. Holinstat

PKC inhibition decreases amphetamine-maintained responding under a progressive-ratio schedule of reinforcement.

• DOI: 10.1037/pha0000425
• 发表时间: 2021-12
• 期刊: Experimental and clinical psychopharmacology
• 影响因子: 2.3
• 作者: Altshuler RD;Mac RC;Gnegy ME;Jutkiewicz EM
• 通讯作者: Jutkiewicz EM

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning.

• DOI: 10.1080/19420862.2022.2146629
• 发表时间: 2022-01
• 期刊: MABS
• 影响因子: 5.3
• 作者: Makowski, Emily K.;Chen, Hongwei;Lambert, Matthew;Bennett, Eric M.;Eschmann, Nicole S.;Zhang, Yulei;Zupancic, Jennifer M.;Desai, Alec A.;Smith, Matthew D.;Lou, Wenjia;Fernando, Amendra;Tully, Timothy;Gallo, Christopher J.;Lin, Laura;Tessier, Peter M.
• 通讯作者: Tessier, Peter M.

Steroidogenic cytochrome P450 17A1 structure and function.

• DOI: 10.1016/j.mce.2021.111261
• 发表时间: 2021-05-15
• 期刊: Molecular and cellular endocrinology
• 影响因子: 4.1
• 作者: Burris-Hiday SD;Scott EE
• 通讯作者: Scott EE

KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression.

• DOI: 10.1073/pnas.2214700120
• 发表时间: 2023-01-17
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Jain, Abhilasha;Stack, Olivia;Ghodrati, Saba;Sanchez-Conde, Francisco G.;Ukachukwu, Chiamaka U.;Salwi, Shreya;Jimenez-Vazquez, Eric N.;Jones, David K.
• 通讯作者: Jones, David K.