Leveraging the 24-hour movement paradigm to preserve cognitive function and prevent Alzheimer's disease: The Multi-Ethnic Study of Atherosclerosis (MESA) 24H-ACT Study

利用 24 小时运动模式保护认知功能并预防阿尔茨海默病：动脉粥样硬化多种族研究 (MESA) 24H-ACT 研究

• 批准号: 10617247
• 负责人: Keith M Diaz
• 金额: $ 188.67万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617247
• 关键词: Acceleration; Accelerometer; Activity Cycles; Address; Adult; Age; Agreement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amyloid; Amyloid beta-Protein; Ancillary Study; Asian; Behavior; Behavioral; Biological Factors; Biological Markers; Black Populations; Black race; Calibration; Categories; Cause of Death; Cerebrovascular Disorders; Cognition; Cognitive; Cognitive aging; Cohort Studies; Complex; Data Analyses; Dementia; Devices; Disparity; Eligibility Determination; Enrollment; Ethnic Origin; Financial Hardship; Future; Goals; Guidelines; Health; Health Benefit; Health behavior; Healthcare Systems; High Prevalence; Hispanic; Hispanic Populations; Hour; Impaired cognition; Individual; Leisures; Light; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mediator; Minority Groups; Modeling; Movement; Multi-Ethnic Study of Atherosclerosis; National Heart, Lung, and Blood Institute; Nerve Degeneration; Not Hispanic or Latino; Onset of illness; Outcome; Participant; Patient Self-Report; Pattern; Pharmacological Treatment; Physical activity; Plasma; Population Heterogeneity; Positron-Emission Tomography; Prevalence; Prevention strategy; Protocols documentation; Public Health; Questionnaires; Race; Recommendation; Recording of previous events; Reporting; Research; Risk; Role; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep disturbances; Time; United States; Woman; Work; actigraphy; adjudication; behavioral phenotyping; brain health; cognitive ability; cognitive function; cognitive performance; cognitive testing; cost; dementia risk; ethnic diversity; high risk; innovation; instrument; light intensity; men; mild cognitive impairment; moderate-to-vigorous physical activity; multi-ethnic; neurofilament; new epidemic; preservation; prevent; prospective; protective factors; racial diversity; research study; resilience; response; screening; sedentary; sedentary lifestyle; sex; sleep behavior; tau Proteins; vigorous intensity; β-amyloid burden

ABSTRACT Alzheimer’s Disease and Related Dementias (ADRD) are an emerging epidemic in the United States (U.S.). Black and Hispanic men and women are particularly vulnerable to ADRD. Without effective prevention strategies to target and optimize resilience to ADRD, 14 million U.S. adults will be living with ADRD by 2060, with an associated financial burden of $511 billion by 2040. While physical activity has been consistently identified as a modifiable, protective factor to prevent cognitive decline and delay age of dementia onset, the majority of this evidence is based on reported estimates of leisure-time moderate to vigorous intensity physical activity (MVPA), which provides an incomplete characterization of this complex behavioral phenotype. Approximately 95% of waking hours are spent sedentary or in light intensity physical activity; however, there is limited research exploring the health impacts of these different intensity categories. Also, less than 10% of adults accumulate sufficient MVPA to meet recommendations, and this prevalence is even lower in minority groups. Studies have also demonstrated that sleep disturbances, particularly sleep duration and sleep- disordered breathing may increase risk of cognitive impairment. However, this body of evidence is still emerging. Further, Black and Hispanic adults have a higher prevalence of disordered sleep compared to Whites. Despite the potential importance of both waking and sleep behaviors to optimize cognitive resilience, their impacts are often studied in isolation. To address these critical research gaps, we propose the Multi- Ethnic Study of Atherosclerosis 24-Hour Activity Cycle Study (MESA 24H-ACT), a four-year ancillary study to MESA. The overall goal of the MESA 24H-ACT Study is to quantify the impact of physical activity and sleep via the 24-hour movement paradigm to preserve cognitive function and prevent Alzheimer’s disease. Participants who meet eligibility criteria and agree to participate (estimated n=2,125) will be included. As part of MESA 24H-ACT, we propose to augment MESA with a 7-day accelerometer and sleep actigraphy protocol to objectively measure the 24-hour activity cycle (sedentary behavior, light intensity physical activity, MVPA, and sleep). To accomplish these goals, this study will examine the associations of 24-hour activity cycle behaviors, ascertained via device-based measures, cross-sectionally with cognition; markers of cerebrovascular disease, neurodegeneration, and amyloid burden; and the prevalence of MCI and dementia (AIM 1); examine self- reported 24-hour activity cycle behaviors with prospective changes in global cognitive function, cerebrovascular disease and neurodegeneration (AIM 2); and elucidate the bidirectional relationship between impaired cognitive function and 24-hour activity cycles over 12 years. MESA 24H-ACT will address current evidence gaps and provide empirical evidence to accelerate a paradigm shift towards an integrated model that incorporates all 24-hour movement behaviors to optimize brain health across racially/ethnically diverse populations.

摘要 阿尔茨海默病和相关痴呆症（ADRD）是美国（U.S.）的一种新兴流行病。 黑人和西班牙裔男性和女性特别容易受到ADRD的影响。如果没有有效的预防 针对和优化ADRD恢复力的战略，到2060年，将有1400万美国成年人患有ADRD， 到2040年，相关的财政负担将达到5110亿美元。虽然体力活动一直是 被认为是一种可改变的保护因素，可以预防认知能力下降和延迟痴呆发作的年龄， 大多数证据是基于报告的估计，休闲时间中度到剧烈强度的身体 活动（MVPA），它提供了一个不完整的表征这种复杂的行为表型。 大约95%的清醒时间是久坐不动或进行轻度体力活动;然而， 探索这些不同强度类别对健康影响的研究有限。此外，不到10%的 成年人积累了足够的MVPA，以满足建议，这种患病率在少数民族中甚至更低 组研究还表明，睡眠障碍，特别是睡眠时间和睡眠- 呼吸紊乱可能会增加认知障碍的风险。然而，这些证据仍然是 正在浮现此外，黑人和西班牙裔成年人的睡眠障碍患病率更高， 白人尽管清醒和睡眠行为对优化认知弹性具有潜在的重要性， 它们的影响往往被孤立地研究。为了解决这些关键的研究差距，我们提出了多- 动脉粥样硬化24小时活动周期研究（梅萨24 H-ACT）的种族研究，一项为期4年的辅助研究， 梅萨。梅萨24 H-ACT研究的总体目标是通过以下方式量化身体活动和睡眠的影响： 24小时运动模式，以保持认知功能和预防阿尔茨海默病。参与者 将纳入符合资格标准并同意参加的患者（估计n= 2，125）。作为梅萨的成员 24 H-ACT，我们建议使用7天加速度计和睡眠活动记录仪方案来增强梅萨， 客观地测量24小时活动周期（久坐行为，轻强度体力活动，MVPA， 睡眠）。为了实现这些目标，本研究将研究24小时活动周期行为， 通过基于设备的测量确定，与认知横截面;脑血管疾病的标志物， 神经变性和淀粉样蛋白负担; MCI和痴呆（AIM 1）的患病率;检查自我 报告了24小时活动周期行为与整体认知功能的前瞻性变化， 脑血管疾病和神经退行性变（AIM 2）;并阐明 认知功能受损和24小时活动周期超过12年。梅萨24 H-ACT将解决当前 证据差距，并提供经验证据，以加速向综合模式的范式转变， 整合所有24小时运动行为，以优化不同种族/民族的大脑健康 人口。

项目成果

Accuracy of 23 Equations for Estimating LDL Cholesterol in a Clinical Laboratory Database of 5,051,467 Patients.

• DOI: 10.5334/gh.1214
• 发表时间: 2023
• 期刊: Global heart
• 影响因子: 3.7
• 作者: Samuel C;Park J;Sajja A;Michos ED;Blumenthal RS;Jones SR;Martin SS
• 通讯作者: Martin SS

Influenza vaccination: a call for cardiologists.

流感疫苗接种：呼吁心脏病专家。

• DOI: 10.1093/eurjpc/zwac196
• 发表时间: 2022
• 期刊: European journal of preventive cardiology
• 影响因子: 8.3
• 作者: Kim,ChangH;Marvel,FrancoiseA;Martin,SethS
• 通讯作者: Martin,SethS

A historical, evidence-based, and narrative review on commonly used dietary supplements in lipid-lowering.

对常用降脂膳食补充剂的历史、循证和叙述性回顾。

• DOI: 10.1016/j.jlr.2023.100493
• 发表时间: 2024
• 期刊: Journal of lipid research
• 影响因子: 6.5
• 作者: Grant,JelaniK;Dangl,Michael;Ndumele,ChiadiE;Michos,ErinD;Martin,SethS
• 通讯作者: Martin,SethS

Hypertriglyceridaemia and cardiovascular mortality: insights from a large-scale study.

高甘油三酯血症和心血管死亡率：来自大规模研究的见解。

• DOI: 10.1093/eurjpc/zwad391
• 发表时间: 2024
• 期刊: European journal of preventive cardiology
• 影响因子: 8.3
• 作者: Patel,Hamza;Grant,JelaniK;Martin,SethS
• 通讯作者: Martin,SethS

Secular Trends in Risk Profiles Among Adults With Cardiovascular Disease in the United States.

• DOI: 10.1016/j.jacc.2022.04.047
• 发表时间: 2022-07-12
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• 影响因子: 24
• 作者: Gao, Yumin;Isakadze, Nino;Duffy, Eamon;Sheng, Qicong;Ding, Jie;MacFarlane, Zane T.;Sang, Yingying;McClure, Scott T.;Selvin, Elizabeth;Matsushita, Kunihiro;Martin, Seth S.
• 通讯作者: Martin, Seth S.