Project 4: Post-Exposure Biomarkers and Remediation of Radionuclide Contaminants
项目4:暴露后生物标志物和放射性核素污染物的修复
基本信息
- 批准号:10589887
- 负责人:
- 金额:$ 51.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-10 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:AccidentsAcidsActinoid Series ElementsAddressAdolescentAnimal ModelAnimalsAreaBiochemistryBiocompatible MaterialsBiologicalBiological MarkersBiologyCardiovascular systemCell physiologyChelating AgentsChemicalsChemistryChildhoodComplexDataData SetDedicationsDepositionDevelopmentDevicesDoseElementsEnvironmentEnvironmental PollutionEnvironmental Risk FactorEvaluationEventExcisionExposure toFemaleGene ExpressionGene Expression AlterationGenesGeneticHealthHeavy MetalsInhalationInjectionsIonsKnowledgeLaboratoriesLigandsLiteratureLungMedicalMeta-AnalysisMetalsModelingMolecularMusNuclearNuclear Reactor AccidentsParticulatePlutoniumPopulationPropertyRadiationRadiation ProtectionRadiation ToxicityRadiation induced damageRadioactiveRadioisotopesRadiology SpecialtyRegulationResearchResearch PriorityRiskRodent ModelSamplingSex DifferencesSignal PathwaySystemTerrorismTherapeuticToxic effectToxicologyTreatment EfficacyTreatment ProtocolsWorkbiomarker discoverychelationcomparison controldesigndosimetrydrug developmentepidemiologic dataexperimental analysisexperimental studyexposed human populationfunctional genomicsimprovedin vivointerestjuvenile animalmalemass casualtymature animalmembermetal chelatormodel developmentnanoscalenovel therapeuticsparticlepreventprogramsremediationrespiratorysample archivesexsex determinationspecific biomarkerstomographytooltranscriptomeuptake
项目摘要
PROJECT 4: ABSTRACT
In the last several years, a sense of urgency and a renewed interest in the study of radionuclide chemistry and
biology have emerged, as threats of nuclear terrorism have become more plausible, as investigational medical
tools have sought the radioactive properties of radionuclides, and as the risk of environmental contamination
and human exposure to radioisotopes consequently increased. In this project, we will pursue the analysis of
radionuclide distribution beyond the MACRO into the MESO, MICRO and NANO scales, in order to improve
dosimetry modeling and biokinetics analyses, in line with biological endpoints, thereby enabling meaningful
countermeasure development in the context of internal emitter exposures. The radiation damage and health risk
presented by internalized radionuclides can be mitigated by the use of mitigators, such as decorporation agents,
that reduce internal contamination. However, most effective agents enhance the elimination of only a limited
range of radionuclides, and some are formulated in ways that would make administration in mass casualty
situations challenging. Therefore, the development of improved decorporation therapies and better delivery
systems for chelators is a research priority in the area of radiological and nuclear threat countermeasures. This
project specifically addresses the urgent need to develop and implement an improved therapy for radioisotope
contamination of a large population. It will establish biokinetic profiles in adult and juvenile animal models, enable
the discovery of biomarkers of exposure, and extend the indication of a new therapeutic decorporation agent to
selected radioisotopes in the form of inhaled particulates, by demonstrating the post-exposure potency of this
product at preventing long-term lung deposition and subsequent damage. In addition, by correlating different
biomarkers of radiation toxicity to countermeasure’s efficacy, this research will provide the foundational data
needed to determine the need for, and course and endpoint of treatment.
项目4:摘要
在过去的几年里,人们对放射性核素化学研究的紧迫感和新的兴趣,
生物学已经出现,因为核恐怖主义的威胁变得更加可信,因为研究医学
工具寻求放射性核素的放射性特性,并作为环境污染的风险
人体暴露于放射性同位素的量也随之增加。在这个项目中,我们将继续分析
将宏观尺度以外的放射性核素分布纳入中、微观和纳米尺度,
剂量学建模和生物学分析,符合生物学终点,从而使有意义的
在内部发射体暴露的背景下制定对策。辐射损害和健康风险
由内化的放射性核素呈现的放射性可以通过使用缓解剂,例如去钙剂,
减少内部污染。然而,大多数有效的药剂仅增强有限的
一系列放射性核素,有些是制定的方式,使管理在大规模伤亡
挑战性的情况。因此,开发改进的脱钙疗法和更好的输送
螯合剂系统是放射性和核威胁对策领域的一个优先研究项目。这
该项目专门针对迫切需要开发和实施放射性同位素的改进疗法
大量人口的污染。它将在成年和幼年动物模型中建立生物动力学特征,
暴露生物标志物的发现,并将新的治疗性脱钙剂的适应症扩展到
选择吸入颗粒形式的放射性同位素,通过证明这种放射性同位素的暴露后效力,
预防长期肺部沉积和随后的损害。此外,通过将不同的
辐射毒性生物标志物对辐射防护效果的影响,本研究将为辐射防护提供基础数据
需要确定治疗的必要性、疗程和终点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rebecca J Abergel其他文献
Rebecca J Abergel的其他文献
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{{ truncateString('Rebecca J Abergel', 18)}}的其他基金
Project 4: Post-Exposure Biomarkers and Remediation of Radionuclide Contaminants
项目4:暴露后生物标志物和放射性核素污染物的修复
- 批准号:
10327399 - 财政年份:2022
- 资助金额:
$ 51.49万 - 项目类别:
Exploring the use of a hydroxypyridinone decorporation agent for the removal of toxic residual gadolinium from MRI contrast agent administration
探索使用羟基吡啶酮脱色剂去除 MRI 造影剂给药中有毒残留的钆
- 批准号:
9387827 - 财政年份:2017
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$ 51.49万 - 项目类别:
Biomimetic Actinide Decorporation: Characterization and Preclinical Development
仿生锕系元素装饰:表征和临床前开发
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7857124 - 财政年份:2009
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$ 51.49万 - 项目类别:
Biomimetic Actinide Decorporation: Characterization and Preclinical Development
仿生锕系元素装饰:表征和临床前开发
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7937967 - 财政年份:2009
- 资助金额:
$ 51.49万 - 项目类别:
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