Cancer Chemical Biology and Metabolism Training Program

癌症化学生物学与代谢培训项目

• 批准号: 10599241
• 负责人: Nika N Danial
• 金额: $ 35.92万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599241
• 关键词: Biology; Chemicals; Malignant Neoplasms; Metabolism; Training Programs

Project Summary/Abstract The faculty of the Dana-Farber Cancer Institute (DFCI) is requesting funds to support a new, integrative, postdoctoral training program in Cancer Chemical Biology and Metabolism (CCBM) — two synergistic and conceptually related research disciplines grounded in small molecule chemistry and biochemistry that are of growing importance from both basic and translational research perspectives. The goals of this program are to: 1) provide training in a wide range of topics relevant to cancer chemical biology and metabolism such as preclinical cancer target validation, chemical screens, structure-based drug discovery, tumor metabolism, cross-talk between tumor and host metabolism, cellular bioenergetics and metabolomics, mechanistic biochemistry, proteomics and chemoproteomics, and animal tumor modelling; 2) familiarize trainees with state- of-the-art technologies and approaches in chemical biology and metabolic science, 3) train fellows to identify important questions and approaches that will move the field forward and provide translational opportunities to impact cancer treatment; 4) provide trainees with opportunities to develop and enhance their grantsmanship and scientific communication skills; 5) coach fellows on their paths to independent careers in science by implementing Individual Development Plans (IDPs), individual postdoctoral mentoring committees, and customized opportunities for trainees to acquire experience in mentoring and teaching depending on their career goals. The CCBM Training Program will support 8 postdoctoral fellows per year for 2-year appointments. It will be administered by a Director (Dr. Thomas Roberts, Contact PD/PI) and a co-Director (Dr. Nika Danial, PD/PI), and will include 26 mentors and 6 co-mentors from 4 departments at DFCI. The program Director and co- Director will work closely with a Training Oversight Committee (TOC), an External Advisory Board (EAB), and a trainee-led advisory group consisting of current and past program fellows who will help identify ways to optimize the program. Additional strategies to measure trainee satisfaction, quantify outcomes, and evaluate the effectiveness of the program will include annual surveys from trainees and mentors, as well as exit and alumni interviews. Institutional support through state-of-the-art core facilities and technology platforms, as well as funds to support T32-specific training activities and yearly EAB meetings will significantly enhance the training program. In addition to offering robust training in a diverse range of scientific and career development skills, a key goal of the program is to recruit and support a more diverse group of trainees. To further ensure the program's effectiveness in enhancing diversity, our EAB and Training Oversight Committee include leaders with deep experience in diversity and inclusion. We believe the integrative CCBM Training Program will prepare fellows for a range of research careers and train the next generation of scientists who will thrive in the 21st century biomedical workforce that will make breakthroughs in cancer research and treatment. !

项目摘要/摘要 达纳 - 法伯癌症研究所（DFCI）的教职员工要求资金支持新的，综合的， 癌症化学生物学和代谢的博士后培训计划（CCBM） - 两种协同作用和 与概念相关的研究学科基础以小分子化学和生物化学为基础 从基本和翻译的研究角度越来越重要。该计划的目标是： 1）提供与癌症化学生物学和代谢相关的广泛主题的培训 临床前癌靶标，化学筛选，基于结构的药物发现，肿瘤代谢， 肿瘤和宿主代谢，细胞生物能学和代谢组学之间的串扰 生物化学，蛋白质组学和化学蛋白质组学以及动物肿瘤建模； 2）熟悉培训与国家 - 化学生物学和代谢科学的艺术技术和方法，3）训练研究员以识别 重要的问题和方法将向前进，并提供转化机会 影响癌症治疗； 4）为受训者提供发展和增强赠款技巧的机会 和科学沟通技巧； 5）教练伙伴在他们通往科学独立职业的道路上 实施个人发展计划（IDP），个人博士后心理委员会和 定制的机会供受训者获得心理和教学经验，具体取决于他们 职业目标。 CCBM培训计划将支持每年8个博士后研究员进行两年约会。这将是 由董事（Thomas Roberts博士，联系PD/PI）和联合导演（Nika Danial博士，PD/PI）管理， 并将包括来自DFCI 4个部门的26位导师和6位联合官员。计划主任兼共同 董事将与培训监督委员会（TOC），外部顾问委员会（EAB）和A紧密合作 由学员领导的咨询小组，由当前和过去的计划研究员组成，他们将帮助确定方法 优化程序。衡量受训者满意度，量化结果和评估的其他策略 该计划的有效性将包括培训和导师的年度调查以及退出和 校友采访。还通过最先进的核心设施和技术平台提供机构支持 作为支持T32特定培训活动和年度EAB会议的资金将大大提高 培训计划。除了在科学和职业发展范围内提供强大的培训 技能，该计划的关键目标是招募和支持更多潜水员的学员。进一步确保 该计划在增强多样性方面的有效性，我们的EAB和培训监督委员会包括领导者 具有多样性和包容性的深刻经验。我们相信CCBM综合培训计划将 为一系列研究职业准备研究员，并培训下一代的科学家，他们将在 21世纪的生物医学劳动力将在癌症研究和治疗方面取得突破。 呢

项目成果

Pseudo-Five-Component Reaction for Diastereoselective Synthesis of Butterfly Shaped Bispiro[Oxindole-Pyrrolidine]s.

• DOI: 10.1021/acs.joc.1c01797
• 发表时间: 2021-11
• 期刊: The Journal of organic chemistry
• 作者: Xiaofeng Zhang;W. Qiu;S. Murray;Desheng Zhan;Jason J Evans;J. Jasinski;Xiao Wang;Wei Zhang

Small Molecule Screening Strategies from Lead Identification to Validation.

从先导化合物识别到验证的小分子筛选策略。

• DOI: 10.3791/64811
• 发表时间: 2023
• 期刊: Journal of visualized experiments : JoVE
• 作者: Kostic,Milka

Three-Component [3+2] Cycloaddition for Regio- and Diastereoselective Synthesis of Spirooxindole-Pyrrolidines.

• DOI: 10.1039/d1nj05538k
• 发表时间: 2022-02-28
• 期刊: New journal of chemistry = Nouveau journal de chimie

Target 2035 - update on the quest for a probe for every protein.

• DOI: 10.1039/d1md00228g
• 发表时间: 2022-01-27
• 期刊: RSC medicinal chemistry
• 影响因子: 4.1
• 作者: Müller S;Ackloo S;Al Chawaf A;Al-Lazikani B;Antolin A;Baell JB;Beck H;Beedie S;Betz UAK;Bezerra GA;Brennan PE;Brown D;Brown PJ;Bullock AN;Carter AJ;Chaikuad A;Chaineau M;Ciulli A;Collins I;Dreher J;Drewry D;Edfeldt K;Edwards AM;Egner U;Frye SV;Fuchs SM;Hall MD;Hartung IV;Hillisch A;Hitchcock SH;Homan E;Kannan N;Kiefer JR;Knapp S;Kostic M;Kubicek S;Leach AR;Lindemann S;Marsden BD;Matsui H;Meier JL;Merk D;Michel M;Morgan MR;Mueller-Fahrnow A;Owen DR;Perry BG;Rosenberg SH;Saikatendu KS;Schapira M;Scholten C;Sharma S;Simeonov A;Sundström M;Superti-Furga G;Todd MH;Tredup C;Vedadi M;von Delft F;Willson TM;Winter GE;Workman P;Arrowsmith CH
• 通讯作者: Arrowsmith CH