2021 Mitochondria in Health and Disease Gordon Research Conference

项目总结 这项申请寻求部分资金，以支持戈登研究会议(GRC)的线粒体 《健康与疾病》将于2021年8月8日至13日举行。这是出现的一系列新的GRC中的第二个 由于线粒体社区内部日益意识到需要一个论坛来捕获和整合 从基础和基础的角度来看，线粒体生物学的广泛快速发展领域 翻译科学。GRC格式特别适合这个论坛，因为它提供了一种设置， 尖端未发表的发现在一个包容的环境中展示，吸引了不同实验室的专家 世界各地举行为期五天的会议。讨论和交流的时间受到严格保护和 在每一次科学会议和下午的空闲时间都受到鼓励。公开讨论的环境 它鼓励合作，并对推进线粒体科学的前沿至关重要。在……里面 除了加快线粒体研究和促进跨学科合作外，这次会议 致力于提高女科学家和少数群体的知名度和参与度。因此，44%的确认 会议项目中的演讲者和44%的讨论负责人是女性。此外，来自中国的简短演讲 摘要将优先用于早期职业科学家、实习生、女性和少数族裔的研究。 此外，由GRC赞助的开放交流论坛Power Hour计划在 会议讨论围绕科学多样性的挑战。会议的另一个目标是培训 线粒体科学方面的研究生和博士后，并提供网络和非正式指导 有机会丰富他们的职业发展。 2021年会议的形式包括9个科学会议，每个会议包括3个完整的演讲和1个 从摘要中精选的简短演讲，以及4个两小时的海报会议。科学会议将有一个 综合关注线粒体生物能量学的新的分子、细胞和生物方面的研究 代谢、氧化还原调节、基因组完整性、蛋白质生物发生和蛋白平衡，以及基于线粒体的 通过载波系统以及细胞器间通信的串扰机制。每个会话都有一个 从基本的生物机制到生理学/病理生理学的各种演讲。因此， 该计划包括高度多样化的主题，同时以从广泛的 方法、实验系统和组织类型，以及涉及的多种疾病的调查 线粒体功能的改变。科学会议以杰出的线粒体生物学家为特色 从久负盛名的研究人员到早期职业科学家，他们的前沿研究在 老龄化、癌症、糖尿病和肥胖症、心血管疾病、神经退行性疾病和先天缺陷 新陈代谢。考虑到线粒体社区内的集体专业知识和研究兴趣， 我们相信，我们的计划将促进富有成效的跨学科互动，推动该领域向前发展。

PROJECT SUMMARY This application seeks partial funds to support the Gordon Research Conference (GRC) on Mitochondria in Health and Disease to be held August 8-13, 2021. This is the second in a new series of GRCs, which emerged from the growing awareness within the mitochondrial community of the need for a forum to capture and integrate a wide range of rapidly evolving areas of mitochondrial biology from the perspective of both basic and translational science. The GRC format is particularly suited for this forum because it provides a setting where cutting edge unpublished findings are presented in an inclusive environment that attracts experts across labs worldwide for a five-day conference. Time for discussions and networking are rigorously protected and encouraged in every scientific session and through free times in the afternoons. A setting where open discussion takes place encourages collaboration and is crucial to advancing the frontiers of mitochondrial science. In addition to accelerating mitochondrial research and promoting cross-disciplinary collaborations, the conference is committed to enhance visibility and participation of women scientists and minorities. As such, 44% of confirmed speakers and 44% of discussion leaders in the conference program are women. In addition, short talks from abstracts will be prioritized to feature research by early career scientists, trainees, women and minorities. Moreover, a GRC-sponsored Power Hour, which is an open communication forum, is scheduled early during the conference to discuss challenges surrounding diversity in science. Another conference objective is to train graduate students and postdocs in mitochondrial science and provide networking and informal mentoring opportunities to enrich their career development. The format of the 2021 conference consists of 9 scientific sessions each composed of 3 full talks and one short talk selected from abstracts, as well as 4 two-hour poster sessions. The scientific sessions will have an integrative focus on novel molecular, cellular and organismal aspects of mitochondrial bioenergetics and metabolism, redox regulation, genome integrity, protein biogenesis, and proteostasis, and mitochondria-based crosstalk mechanisms via carrier systems as well as interorganellar communications. Each session has a mixture of talks ranging from fundamental biologic mechanisms to physiology/pathophysiology. As such, the program includes highly diverse topics while featuring frontiers of knowledge gained from a broad range of approaches, experimental systems and tissue types, as well as investigation of multiple diseases involving alterations in mitochondrial function. The scientific sessions feature outstanding mitochondrial biologists ranging from established investigators to early career scientists whose cutting-edge research has had high impact in the fields of aging, cancer, diabetes and obesity, cardiovascular disease, neurodegeneration, and inborn errors of metabolism. Given the collective breadth of expertise and research interests within the mitochondrial community, we believe our program will catalyze productive cross-disciplinary interactions to propel the field forward.