Investigating cell-intrinsic and extrinsic interactions in prostate cancer at the single cell level

在单细胞水平上研究前列腺癌的细胞内在和外在相互作用

基本信息

  • 批准号:
    10612346
  • 负责人:
  • 金额:
    $ 205.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-01 至 2027-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Prostate cancer progression to metastatic castration-resistant disease continues to represent a major health issue. Recent advances in single-cell approaches have revealed extensive heterogeneity and complexity of cell states and cell types that drive tumor progression, and additional studies have demonstrated the central role of the tumor microenvironment. Consequently, we are proposing a new Program Project to investigate the interplay between tumor cells and their surrounding stromal and immune microenvironment in promoting prostate cancer progression, metastasis, and treatment-resistance. Our proposal is highly integrated as it brings together a multi-institutional team of four distinguished investigators (Michael Shen, Charles Sawyers, Cory Abate-Shen, Massimo Loda) in the study of prostate cancer who have complementary expertise as well as a substantial track record of collaborative interactions. We have structured our application around the following projects and cores: Project 1, led by Charles Sawyers (Memorial Sloan-Kettering Cancer Center), will investigate the immune and stromal factors that promote prostate adenocarcinoma and castration-response. Project 2, led by Cory Abate-Shen (Columbia University Irving Medical Center; CUIMC), will investigate the cell intrinsic and extrinsic drivers of prostate cancer metastasis to bone. Project 3, led by Michael Shen (CUIMC), who is also overall PI, will analyze the intrinsic and extrinsic factors that promote prostate neuroendocrine differentiation. Core A (Pathobiology), led by Massimo Loda (Weill Cornell Medicine), will provide multiple pathology-based services to all three Projects. Finally, Core B (Administrative and Data Management), led by Michael Shen, will support each Project through data management, biostatistical support, and coordination of the overall program, resource management, and review by the Internal and External Advisory Boards. Together, this highly synergistic program will elucidate the integration of intrinsic and extrinsic signals that drive castration-resistance, metastatic tropism, and neuroendocrine differentiation in prostate cancer, and will provide translational insights into the stromal and immune microenvironments for improved therapeutic approaches.
项目总结/文摘

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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MICHAEL M. SHEN其他文献

MICHAEL M. SHEN的其他文献

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{{ truncateString('MICHAEL M. SHEN', 18)}}的其他基金

Project 3: Analysis of intrinsic and extrinsic factors that promote prostate neuroendocrine differentiation
项目3:促进前列腺神经内分泌分化的内在和外在因素分析
  • 批准号:
    10612357
  • 财政年份:
    2022
  • 资助金额:
    $ 205.58万
  • 项目类别:
Core B: Administrative and Data Management Core
核心 B:行政和数据管理核心
  • 批准号:
    10333946
  • 财政年份:
    2022
  • 资助金额:
    $ 205.58万
  • 项目类别:
Project 3: Analysis of intrinsic and extrinsic factors that promote prostate neuroendocrine differentiation
项目3:促进前列腺神经内分泌分化的内在和外在因素分析
  • 批准号:
    10333945
  • 财政年份:
    2022
  • 资助金额:
    $ 205.58万
  • 项目类别:
Core B: Administrative and Data Management Core
核心 B:行政和数据管理核心
  • 批准号:
    10612361
  • 财政年份:
    2022
  • 资助金额:
    $ 205.58万
  • 项目类别:
Investigating cell-intrinsic and extrinsic interactions in prostate cancer at the single cell level
在单细胞水平上研究前列腺癌的细胞内在和外在相互作用
  • 批准号:
    10333942
  • 财政年份:
    2022
  • 资助金额:
    $ 205.58万
  • 项目类别:
Genetic Approaches to Development and Disease
发育和疾病的遗传学方法
  • 批准号:
    10206946
  • 财政年份:
    2021
  • 资助金额:
    $ 205.58万
  • 项目类别:
Investigating lineage plasticity in castration-resistant prostate cancer
研究去势抵抗性前列腺癌的谱系可塑性
  • 批准号:
    10441364
  • 财政年份:
    2020
  • 资助金额:
    $ 205.58万
  • 项目类别:
Investigating lineage plasticity in castration-resistant prostate cancer
研究去势抵抗性前列腺癌的谱系可塑性
  • 批准号:
    10656234
  • 财政年份:
    2020
  • 资助金额:
    $ 205.58万
  • 项目类别:
Investigating lineage plasticity in castration-resistant prostate cancer
研究去势抵抗性前列腺癌的谱系可塑性
  • 批准号:
    10033614
  • 财政年份:
    2020
  • 资助金额:
    $ 205.58万
  • 项目类别:
Investigating lineage plasticity in castration-resistant prostate cancer
研究去势抵抗性前列腺癌的谱系可塑性
  • 批准号:
    10164741
  • 财政年份:
    2020
  • 资助金额:
    $ 205.58万
  • 项目类别:

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