Core B: Administrative and Data Management Core

核心 B：行政和数据管理核心

• 批准号: 10333946
• 负责人: MICHAEL M. SHEN
• 金额: $ 52.55万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333946
• 关键词: Abate; Area; Bass; Biometry; Budgets; Cancer Center; Cells; Collaborations; Communication; Communities; Complex; Conflict (Psychology); Dana-Farber Cancer Institute; Data; Ensure; Evaluation; Feedback; Fostering; Future; Genetically Engineered Mouse; Genomics; Health Sciences; Human Resources; Individual; Infrastructure; Institution; Laboratories; Laboratory Personnel; Leadership; Logistics; Malignant neoplasm of prostate; Medical center; Medicine; Memorial Sloan-Kettering Cancer Center; Mission; Modeling; Molecular Analysis; Monitor; Mouse Strains; Office of Administrative Management; Oregon; Organoids; Participant; Pharmacologic Substance; Preparation; Program Reviews; Progress Reports; Research; Research Personnel; Resolution; Resource Sharing; Resources; Scientist; Structure; The Jackson Laboratory; Time; Universities; data management; data resource; data sharing; experience; genomic data; laboratory experiment; meetings; member; operation; programs; recruit; single cell sequencing; success; synergism

Project Summary/Abstract The Administrative and Data Management Core will provide coordination and oversight of all activities of the Projects and Cores in this Program, and will maximize interactions and potential synergies among Project Leaders, Core Leaders, and laboratory personnel at the three participating institutions: Columbia University Irving Medical Center (CUIMC), Memorial Sloan Kettering Cancer Center (MSKCC), and Weill Cornell Medicine (WCM). The major scientific functions of the Core will be to provide expert support for data management, biostatistics, and resource sharing for the Projects and Core A. In addition, to facilitate program integration and effective communication among its various members, the Core will organize monthly meetings composed of two parts: (i) Research presentations, which will include all program participants, as well as relevant Internal Advisory Board members; and (ii) Executive meetings, which will be limited to the Executive Committee (Drs. Shen, Abate- Shen, Sawyers, and Loda) and members of the Internal Advisory Board. The latter meetings will provide a forum for candid assessment of research progress, oversight of Core utilization, prioritization of resources and objectives, and resolution of potential conflicts. In addition, the Data Management component will organize monthly meetings of the computational biologists on all Projects and Core A to ensure effective integration of single-cell sequencing data. An important function of the Core will be to provide logistical support through management of data and resources, fiscal review and budget analysis, preparation of progress reports, and regulatory compliance. Finally, the Core will organize an annual full-day review of the Program Project by members of the Internal and External Advisory Boards, who will provide detailed feedback on research progress and future directions, as well as advice on program management. This Core will have the following specific aims: (1) Data management for the Projects and Core A, which will be led by co-Investigator, Dr. Aristidis Floratos (CUIMC); (2) Biostatistical support for the Projects and Core A, which will be led by Dr. Glen Heller (MSKCC); and (3) Program management, which will include: (a) Coordination of the overall program by maintaining the organization of the program and establishing mechanisms for effective interaction among its personnel; (b) Data and resource sharing by promoting effective utilization of Core A, and by facilitating data and resource sharing with external laboratories, including access to complex mouse strains through the Jackson Laboratory; (c) Review of the Program Project by Internal and External Advisory Boards to evaluate ongoing progress of each Project, review the functionality of the Cores, and provide advice on future research directions. Taken together, the operations of the Administrative and Data Management Core will ensure the smooth and efficient functioning of the overall Program, as well as planning and oversight for its operations, and will promote the sharing of data and resources within the Program Project as well as with external investigators.

项目摘要/摘要 行政和数据管理核心将协调和监督下列各项活动 本计划中的项目和核心，并将最大限度地提高项目之间的互动和潜在协同效应 三个参与机构的领导者、核心领导者和实验室人员：哥伦比亚大学 欧文医疗中心(CUIMC)、纪念斯隆·凯特琳癌症中心(MSKCC)和威尔·康奈尔医学 (WCM)。核心的主要科学职能将是为数据管理提供专家支持， 项目和核心A的生物统计和资源共享。此外，促进方案整合和 为加强各成员之间的有效沟通，核心委员会将每月组织两次会议 部分：(1)研究报告，将包括所有方案参与者以及相关的内部咨询 董事会成员；和(2)执行会议，这将仅限于执行委员会(沈博士、阿巴特博士-- 沈、索耶斯和罗达)和内部咨询委员会成员。后几次会议将提供一个论坛 坦率地评估研究进展、监督核心利用情况、确定资源的优先顺序和 目标和潜在冲突的解决。此外，数据管理部门将组织 计算生物学家关于所有项目和核心A的每月会议，以确保有效地整合 单细胞测序数据。核心的一个重要职能将是通过以下方式提供后勤支持 管理数据和资源、财政审查和预算分析、编写进度报告和 监管合规性。最后，核心将通过以下方式组织对方案项目的年度全天审查 内部和外部咨询委员会成员，他们将就研究进展提供详细反馈 以及未来的方向，以及对项目管理的建议。 这一核心将有以下具体目标：(1)项目和核心A的数据管理， 将由共同调查员阿里斯蒂迪斯·弗洛拉托斯博士(CUIMC)领导；(2)对项目和核心项目的生物统计支持 A将由Glen Heller博士(MSKCC)领导；和(3)计划管理，其中将包括：(A) 通过维护计划的组织和建立机制来协调整个计划 促进其工作人员之间的有效互动；(B)通过促进有效利用 核心A，并促进与外部实验室的数据和资源共享，包括进入综合体 杰克逊实验室的小鼠品系；(C)内部和外部对该计划项目的审查 咨询委员会，评估每个项目的持续进展，审查核心的功能，并提供 对未来研究方向的建议。总而言之，管理和数据管理的操作 CORE将确保整个方案的顺利和有效运作，以及规划和监督 用于其业务，并将促进方案项目内以及与 外部调查人员。