Core B: Administrative and Data Management Core

核心 B：行政和数据管理核心

• 批准号: 10612361
• 负责人: MICHAEL M. SHEN
• 金额: $ 25.36万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612361
• 关键词: Abate; Area; Bass; Biometry; Budgets; Cancer Center; Cells; Collaborations; Communication; Communities; Complex; Dana-Farber Cancer Institute; Data; Ensure; Equity; Evaluation; Feedback; Fostering; Future; Genetically Engineered Mouse; Genomics; Health; Human Resources; Individual; Infrastructure; Institution; Laboratories; Laboratory Personnel; Leadership; Malignant neoplasm of prostate; Medical center; Medicine; Memorial Sloan-Kettering Cancer Center; Mission; Modeling; Molecular Analysis; Monitor; Mouse Strains; Office of Administrative Management; Oregon; Organization administrative structures; Organoids; Participant; Pharmacologic Substance; Preparation; Program Reviews; Progress Reports; Research; Research Personnel; Resolution; Resource Sharing; Resources; Science; Scientist; Structure; The Jackson Laboratory; Time; Universities; conflict resolution; data management; data sharing; experience; genomic data; laboratory experiment; meetings; member; operation; programs; recruit; single cell sequencing; success; synergism

Project Summary/Abstract The Administrative and Data Management Core will provide coordination and oversight of all activities of the Projects and Cores in this Program, and will maximize interactions and potential synergies among Project Leaders, Core Leaders, and laboratory personnel at the three participating institutions: Columbia University Irving Medical Center (CUIMC), Memorial Sloan Kettering Cancer Center (MSKCC), and Weill Cornell Medicine (WCM). The major scientific functions of the Core will be to provide expert support for data management, biostatistics, and resource sharing for the Projects and Core A. In addition, to facilitate program integration and effective communication among its various members, the Core will organize monthly meetings composed of two parts: (i) Research presentations, which will include all program participants, as well as relevant Internal Advisory Board members; and (ii) Executive meetings, which will be limited to the Executive Committee (Drs. Shen, Abate- Shen, Sawyers, and Loda) and members of the Internal Advisory Board. The latter meetings will provide a forum for candid assessment of research progress, oversight of Core utilization, prioritization of resources and objectives, and resolution of potential conflicts. In addition, the Data Management component will organize monthly meetings of the computational biologists on all Projects and Core A to ensure effective integration of single-cell sequencing data. An important function of the Core will be to provide logistical support through management of data and resources, fiscal review and budget analysis, preparation of progress reports, and regulatory compliance. Finally, the Core will organize an annual full-day review of the Program Project by members of the Internal and External Advisory Boards, who will provide detailed feedback on research progress and future directions, as well as advice on program management. This Core will have the following specific aims: (1) Data management for the Projects and Core A, which will be led by co-Investigator, Dr. Aristidis Floratos (CUIMC); (2) Biostatistical support for the Projects and Core A, which will be led by Dr. Glen Heller (MSKCC); and (3) Program management, which will include: (a) Coordination of the overall program by maintaining the organization of the program and establishing mechanisms for effective interaction among its personnel; (b) Data and resource sharing by promoting effective utilization of Core A, and by facilitating data and resource sharing with external laboratories, including access to complex mouse strains through the Jackson Laboratory; (c) Review of the Program Project by Internal and External Advisory Boards to evaluate ongoing progress of each Project, review the functionality of the Cores, and provide advice on future research directions. Taken together, the operations of the Administrative and Data Management Core will ensure the smooth and efficient functioning of the overall Program, as well as planning and oversight for its operations, and will promote the sharing of data and resources within the Program Project as well as with external investigators.

项目摘要/摘要 行政和数据管理核心将提供协调和监督 该计划中的项目和核心将最大化项目之间的互动和潜在协同作用 三个参与机构的领导人，核心领导者和实验室人员：哥伦比亚大学 欧文医疗中心（CUIMC），纪念斯隆·克特林癌症中心（MSKCC）和威尔·康奈尔医学 （WCM）。核心的主要科学功能是为数据管理提供专家支持， 生物统计学和项目和核心A的资源共享。此外，以促进计划集成和 核心将在其各个成员之间进行有效的沟通，将组织每月的会议。 部分：（i）研究演示文稿，其中包括所有计划参与者以及相关的内部咨询 董事会成员； （ii）执行会议，该会议仅限于执行委员会（Shen Dr.Shen，Abate- Shen，Sawyers和Loda）以及内部顾问委员会成员。后一个会议将提供论坛 坦率地评估研究进度，核心利用的监督，资源的优先级和 目标，并解决潜在的冲突。此外，数据管理组件将组织 计算生物学家关于所有项目和核心A的每月会议，以确保有效整合 单细胞测序数据。核心的重要功能是通过 数据和资源管理，财政审查和预算分析，进度报告的准备以及 法规合规性。最后，核心将组织该计划项目的年度全天审查 内部和外部咨询委员会的成员，他们将提供有关研究进度的详细反馈 以及未来的指示以及有关计划管理的建议。 该核心将具有以下特定目标：（1）项目和核心A的数据管理 将由共同投资者Aristidis Floratos（Cuimc）领导； （2）对项目和核心的生物统计支持 A，由Glen Heller博士（MSKCC）领导； （3）计划管理，其中包括：（a） 通过维护计划的组织并建立机制来协调整体计划 在其人员之间有效互动； （b）通过促进有效利用的数据和资源共享 核心A，并通过促进与外部实验室的数据和资源共享，包括访问复杂 老鼠通过杰克逊实验室的菌株； （c）内部和外部对计划项目的审查 评估每个项目正在进行的进度，查看核心功能并提供的咨询委员会 关于未来的研究方向的建议。综上所述，行政和数据管理的运营 核心将确保整个计划的平稳有效运作，以及计划和监督 为其运营，并将促进计划项目中的数据和资源共享 外部调查人员。