Profiling and Mapping Core

分析和映射核心

基本信息

  • 批准号:
    10271480
  • 负责人:
  • 金额:
    $ 45.07万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2026-04-30
  • 项目状态:
    未结题

项目摘要

Profiling and Mapping Core B Project Leaders: Kyu Rhee and D. Branch Moody Co-investigators: Jacob Mayfield ABSTRACT - Profiling and Mapping Core B Modern infectious disease research relies fundamentally on genomic maps of the major pathogens. With the recent development of whole-organism metabolomics profiling tools, comprehensively mapping the M. tuberculosis (Mtb) metabolome is now feasible. Core B supports mass spectrometry-based profiling of Mtb metabolites to support Projects 1, 2 and 3 that focus on discovery, drugs and diagnostics, respectively. The Core will carry out whole-organism lipidomic and metabolomic profiling, archive datasets and use modern bioinformatic methods to generate metabo-lipidomic maps of Mtb. Maps are comprised of a structured listing of all metabolite subclasses, a list of all named metabolites within each class, and links of all named metabolites to mass values and other biological variables. We previously generated the MycoMap Database, which is the largest existing map of 183 mycobacterial metabolite classes linked to ~195,000 accurate mass values. We will now expand the database by adding newly discovered lipids generated in Projects 1, 2 and 3. Supporting Projects 1 and 2, we will solve the Mycolate Outer Membrane Lipid Map, which describes compounds located at the host-pathogen barrier and involved in drug penetration. Supporting Projects 1 and 3, the core will measure metabolite variation among Mtb strains from South African patients to generate the Human Mtb Strain Lipid Variation Database. This database will describe the prevalence and variation of lipids among strains circulating in human communities to identify lipids under control by host selection and to support diagnostics development.
分析和映射核心B

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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DAVID Branch MOODY其他文献

DAVID Branch MOODY的其他文献

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{{ truncateString('DAVID Branch MOODY', 18)}}的其他基金

Chemical Biological Discovery of Lipid Virulence Factors in the Major Bacterial Pathogens
主要细菌病原体中脂质毒力因子的化学生物学发现
  • 批准号:
    10518252
  • 财政年份:
    2022
  • 资助金额:
    $ 45.07万
  • 项目类别:
Chemical Biological Discovery of Lipid Virulence Factors in the Major Bacterial Pathogens
主要细菌病原体中脂质毒力因子的化学生物学发现
  • 批准号:
    10651853
  • 财政年份:
    2022
  • 资助金额:
    $ 45.07万
  • 项目类别:
Profiling and Mapping Core
分析和映射核心
  • 批准号:
    10612026
  • 财政年份:
    2021
  • 资助金额:
    $ 45.07万
  • 项目类别:
Study of M. tuberculosis under human host selection to identify virulence and barrier lipids (Project 1)
研究人类宿主选择下的结核分枝杆菌以确定毒力和屏障脂质(项目 1)
  • 批准号:
    10612035
  • 财政年份:
    2021
  • 资助金额:
    $ 45.07万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10271479
  • 财政年份:
    2021
  • 资助金额:
    $ 45.07万
  • 项目类别:
Metabolic adaptions of Mycobacterium tuberculosis at diverse host-pathogen interfaces
结核分枝杆菌在不同宿主-病原体界面的代谢适应
  • 批准号:
    10630740
  • 财政年份:
    2021
  • 资助金额:
    $ 45.07万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10612024
  • 财政年份:
    2021
  • 资助金额:
    $ 45.07万
  • 项目类别:
Profiling and Mapping Core
分析和映射核心
  • 批准号:
    10438913
  • 财政年份:
    2021
  • 资助金额:
    $ 45.07万
  • 项目类别:
Metabolic determinants of Mtb virulence, vulnerability and variation
结核分枝杆菌毒力、脆弱性和变异的代谢决定因素
  • 批准号:
    10438911
  • 财政年份:
    2021
  • 资助金额:
    $ 45.07万
  • 项目类别:
Metabolic determinants of Mtb virulence, vulnerability and variation
结核分枝杆菌毒力、脆弱性和变异的代谢决定因素
  • 批准号:
    10612023
  • 财政年份:
    2021
  • 资助金额:
    $ 45.07万
  • 项目类别:

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光是否决定了细菌领域的古代系统发育和细胞结构的多样化?
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