项目1-猫眼课题宝

项目1

批准号：

10270978

负责人：

Abraam M. Yakoub

金额：

$25.37万

依托单位：

UNIVERSITY OF NORTH DAKOTA

依托单位国家：

美国

项目类别：

财政年份：

2016

资助国家：

美国

项目状态：

未结题

起止时间：

2016-05-13 至 2026-06-30

来源：

https://reporter.nih.gov/project-details/10270978

关键词：

2019-nCoV ACE2 American Animal Model Antiviral Agents Antiviral Therapy Applications Grants Area Basic Science Biochemical COVID-19 COVID-19 pathogenesis COVID-19 treatment Cells Centers of Research Excellence Cessation of life Collaborations Core Facility Country Disasters Disease Ensure FDA approved Faculty Fluorescence Foundations Future Genetic Models Goals Human Immune Immune response In Vitro Individual Infection Inflammatory Response Innate Immune Response Knowledge Libraries Measurement Mediating Methods Mission Molecular Molecular Genetics Mus Outcome Pathogenesis Pharmacotherapy Pneumonia Predisposition Public Health Reporter Reporting Research Research Project Grants Resources Respiratory Failure Role SARS-CoV-2 infection SARS-CoV-2 pathogenesis Severe Acute Respiratory Syndrome Severities Testing Therapeutic Intervention Tissues Tropism United States National Institutes of Health Vaccines Viral Viral Pathogenesis Virulence Virus Virus Diseases Virus Inhibitors Writing animal tissue base betacoronavirus drug candidate drug discovery effective therapy experience immunoregulation in vivo in vivo Model inhibitor/antagonist insight mouse model novel novel therapeutics pandemic disease pathogen receptor small molecule success synergism targeted treatment therapeutic evaluation therapy development tissue tropism viral entry inhibitor virology virus tropism

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Summary Coronavirus Disease of 2019 (COVID-19) is a US and global public health crisis. It has led to the deaths of hundreds of thousands in the US and worldwide. COVID-19 is caused by a novel beta-coronavirus (CoV) known as Severe Acute Respiratory Syndrome (SARS)-CoV-2, which was reported to cause severe pneumonia and lethal respiratory failure. Little is known about the disease mechanism of this virus. Thus, animal models are urgently needed to start to investigate the SARS-CoV-2 pathogenesis mechanisms or test therapeutic interventions. In this application, we propose to establish the tissue tropism of SARS-CoV-2 in vivo by comparing two different mouse models that show moderate or severe disease in parallel. We also propose to test compound libraries to identify inhibitors of viral infection as drug candidates for COVID-19. We will also determine how the virus modulates innate immune responses in vivo in order to establish virulence. The proposed research will have manifold impact on the scientific battlefront on SARS-CoV-2 and the deadly COVID-19.

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