Developmental Research Program

发展研究计划

• 批准号: 10270458
• 负责人: Diane F Jelinek
• 金额: $ 14.42万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270458
• 关键词: Area; Basic Science; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Development; Discipline; Fostering; Foundations; Fruit; Funding; Future; Goals; Grant; Incidence; Infrastructure; Laboratory Study; Mayo Clinic Cancer Center; Monitor; Multiple Myeloma; Patients; Pilot Projects; Quality of life; Recommendation; Research; Research Personnel; Research Project Grants; Research Support; Scientist; Seeds; Techniques; Testing; Translating; Translational Research; United States National Institutes of Health; base; improved; improved outcome; innovation; mortality; novel; programs; sound; translational study; tumor

ABSTRACT: Developmental Research Program (DRP). The goal of the Developmental Research Program in the Mayo Clinic SPORE in Multiple Myeloma is to support innovative, scientifically sound projects that investigate any area pertaining to translational myeloma research. Funding from this program will stimulate developmental research that incorporates techniques and theoretical approaches that may not have been previously utilized in myeloma research. In so doing it provides a mechanism by which the SPORE can increase the number of scientists and clinical investigators who are committed to translational myeloma research. The Developmental Research Program will encourage the development of suitable projects, coordinate project review and selection, make funding recommendations to the Executive Committee, and monitor research progress. We have requested $140,000 annually ($90,000 per year from the SPORE funds augmented by $50,000 per year in matching funds from the Mayo Clinic Cancer Center) for the Developmental Research Program. We aim to provide research support to three to four projects per year for one year with a second year of support possible based on exceptional progress towards the stated aims of the project. The long term goal is to translate the findings generated by developmental projects into a reduction in the incidence and mortality rates of myeloma. Without the funding, infrastructure, and expertise of the SPORE projects and investigators, it will be unlikely that innovative developmental research projects of the kind we envision can be brought to fruition. Specifically, the primary goals of the Developmental Research Program are to: (1) encourage innovative translational studies that are promising and have the potential to improve outcome in myeloma and mature into independently funded projects; (2) foster extensive collaboration between basic science and clinical disciplines in translational research in myeloma in the context of the myeloma SPORE program; (3) encourage investigators to apply their research findings in other tumor types to translational research in myeloma and; (4) generate new hypotheses that can be tested and provide the foundation for future largescale research projects or clinical trials in order to reduce myeloma incidence and mortality rates.

摘要：发展研究计划。发展研究计划的目标 在马约诊所的多发性骨髓瘤孢子是支持创新，科学合理的项目， 研究任何与转译骨髓瘤研究有关的领域。该计划的资金将刺激 发展研究，包括技术和理论方法，可能没有被 以前用于骨髓瘤研究。在这样做时，它提供了一种机制，通过该机制，孢子可以 增加致力于转化型骨髓瘤的科学家和临床研究者的数量 research.发展研究计划将鼓励发展合适的项目， 协调项目审查和选择，向执行委员会提出资金建议， 监测研究进展。我们要求每年提供140，000美元（每年从SPORE基金中提供90，000美元 由马约诊所癌症中心提供的配套资金每年增加50，000美元），用于发展 研究计划。我们的目标是每年为三至四个项目提供研究支援，为期一年， 根据在实现项目既定目标方面取得的特殊进展，可能提供第二年的支助。的 长期目标是将发展项目产生的结果转化为发病率的降低 以及骨髓瘤的死亡率。如果没有SPORE项目的资金、基础设施和专业知识， 研究人员，这将是不太可能的，我们设想的那种创新的发展研究项目可以 结出了果实具体而言，发展研究计划的主要目标是：（1） 鼓励创新的转化研究，这是有前途的，并有可能改善结果， 骨髓瘤和成熟到独立资助的项目;（2）促进基础之间的广泛合作 骨髓瘤孢子背景下骨髓瘤转化研究的科学和临床学科 （3）鼓励研究者将他们在其他肿瘤类型中的研究成果应用于翻译 骨髓瘤的研究;（4）产生新的假设，可以测试，并提供基础， 未来的大规模研究项目或临床试验，以降低骨髓瘤的发病率和死亡率。