CBT by Phone to Promote Use of Alcohol Related Care and Reduce Drinking

通过电话进行 CBT，以促进使用酒精相关护理并减少饮酒

• 批准号: 10244416
• 负责人: KENNETH R CONNER
• 金额: $ 14.96万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244416
• 关键词: Address; Adult; Affect; African American; Alcohol consumption; Alcohols; Area; Behavioral; COVID-19; COVID-19 outbreak; COVID-19 pandemic; Caring; Cessation of life; Cognitive Therapy; Communities; Control Groups; Data; Data Collection; Diagnosis; Exposure to; Family member; Funding; Grant; Health; Hospitalization; Individual; Intervention; Intervention Studies; Learning; Length; Life; Light; Longitudinal cohort; Measures; Modeling; National Institute on Alcohol Abuse and Alcoholism; Natural experiment; New York; New York City; Not Hispanic or Latino; Outcome; Pamphlets; Parents; Population; Post-Traumatic Stress Disorders; Quality of life; Race; Randomized; Randomized Controlled Trials; Recording of previous events; Research; Resources; Risk; SARS-CoV-2 infection; Sample Size; Sampling; Standardization; Stress; Telephone; Time; Veterans; Waxes; alcohol abuse therapy; alcohol measurement; alcohol related consequences; alcohol seeking behavior; alcohol use disorder; base; behavioral economics; brief intervention; cohort; drinking; economic impact; efficacy evaluation; efficacy testing; experience; follow-up; improved; novel; prospective; racial difference; racial disparity; recruit; resilience; response; social; social media; volunteer

The COVID-19 pandemic has major implications for alcohol use and treatment utilization for alcohol use disorder (AUD), and there are pronounced racial disparities in COVID-19 experiences including higher rates of COVID-19 infections, hospitalizations, and deaths in Blacks, serving as the foci of this COVID-19 supplement. More specifically, this supplement covers the final 2 years of a 4-year randomized controlled trial (RCT) to examine the efficacy of a one-session phone intervention, Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS), to increase AUD treatment utilization and reduce drinking. Subjects are adult volunteers with AUD recruited from the Rochester, New York area through social media who have no prior history of AUD treatment. Following a baseline assessment, subjects are randomized to CBT-TS or a control condition (being read an information pamphlet on AUD treatment) and followed for 6 months. One year into recruitment for the RCT, in March 2020, a statewide executive order was issued in response to the COVID-19 pandemic that swept into New York City, with sudden and dramatic effects throughout the state. A month later, the study team began to administer a detailed assessment of COVID-19 experiences to assess subjects' personal exposure to COVID- 19, exposure of family members, stress related to COVID-19, and alcohol use affected by COVID-19. Through this supplement, these data at the population level (marked by the executive order) and at the individual level (obtained through the COVID-19 assessment) are used to analyze COVID-19 related experiences and their prospective associations with AUD treatment utilization, drinking outcomes, and response to the study intervention (Specific Aim 1) and to explore racial disparities through comparisons of Blacks and white non- Hispanics (Specific Aim 2). Moreover, pilot research suggests that Blacks may be especially responsive to the CBT-TS intervention, underscoring the importance of further study of the intervention in this population. To achieve the two study aims, the supplement provides resources to increase the length of follow-up (from 6 months to 12 months) which is needed to model effects of COVID-19 experiences over time, and to increase the sample size (from n=450 to n=500), with a priority on increased recruitment of Blacks (to reach n=100) to facilitate sub-analyses and comparisons with white non-Hispanics. This supplement is in response to NOT-OD- 20-097 and addresses the emphases in the NOSI on “downstream health impacts resulting from (COVID-19 related) social, behavioral, and economic impacts, including (race) differences in risk and resiliency.” Moreover, it is responsive to its call for “active grants studying existing longitudinal cohorts, particularly those cohorts with considerable data relevant to COVID-19 social and behavioral factors prior and subsequent to the (COVID-19) outbreak.” Along these lines, the statewide executive order was issued at the midpoint of data collection, optimal for the examination of the cohort before and after exposure to COVID-19.

COVID-19 大流行对饮酒和饮酒治疗利用产生重大影响 障碍（AUD），并且在 COVID-19 经历中存在明显的种族差异，包括更高的患病率 黑人的 COVID-19 感染、住院和死亡，是本次 COVID-19 补充的重点。 更具体地说，本补充涵盖了为期 4 年的随机对照试验 (RCT) 的最后 2 年，以 检查一次性电话干预（寻求治疗的认知行为疗法）的效果 (CBT-TS)，以提高澳元治疗利用率并减少饮酒。受试者是持有 AUD 的成年志愿者 通过社交媒体从纽约州罗切斯特地区招募没有 AUD 治疗史的人。 基线评估后，受试者被随机分配到 CBT-TS 或控制条件（正在阅读 AUD 治疗信息小册子）并随访 6 个月。 RCT 招募一年后， 2020 年 3 月，针对席卷美国的 COVID-19 大流行发布了一项全州行政命令 纽约市，对整个州产生了突然而戏剧性的影响。一个月后，研究小组开始 对 COVID-19 经历进行详细评估，以评估受试者个人接触 COVID-19 的情况 19、家庭成员的接触、与 COVID-19 相关的压力以及受 COVID-19 影响的饮酒。通过 在本补充文件中，这些数据在人口层面（由行政命令标记）和个人层面 （通过 COVID-19 评估获得）用于分析 COVID-19 相关经历及其 与 AUD 治疗利用率、饮酒结果和对研究的反应的前瞻性关联 干预（具体目标 1）并通过比较黑人和白人非 西班牙裔（具体目标 2）。此外，试点研究表明，黑人可能对 CBT-TS 干预，强调了进一步研究该人群干预措施的重要性。到 为了实现这两个研究目标，该补充提供了资源以增加随访时间（从 6 几个月到 12 个月），这需要模拟 COVID-19 经历随时间的影响，并增加 样本量（从 n=450 到 n=500），优先考虑增加招募黑人（达到 n=100） 促进与非西班牙裔白人的细分分析和比较。本补充是为了回应 NOT-OD- 20-097 并强调了 NOSI 中关于“（COVID-19）造成的下游健康影响” 相关的）社会、行为和经济影响，包括风险和弹性的（种族）差异。” 此外，它响应了“积极拨款研究现有纵向队列，特别是那些 在研究之前和之后拥有大量与 COVID-19 社会和行为因素相关的数据的队列 （2019冠状病毒病暴发。”按照这些思路，全州行政命令是在数据中点发布的 收集，最适合在接触 COVID-19 之前和之后检查队列。