CBT by Phone to Promote Use of Alcohol Related Care and Reduce Drinking

通过电话进行 CBT，以促进使用酒精相关护理并减少饮酒

• 批准号: 10244416
• 负责人: KENNETH R CONNER
• 金额: $ 14.96万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244416
• 关键词: Address; Adult; Affect; African American; Alcohol consumption; Alcohols; Area; Behavioral; COVID-19; COVID-19 outbreak; COVID-19 pandemic; Caring; Cessation of life; Cognitive Therapy; Communities; Control Groups; Data; Data Collection; Diagnosis; Exposure to; Family member; Funding; Grant; Health; Hospitalization; Individual; Intervention; Intervention Studies; Learning; Length; Life; Light; Longitudinal cohort; Measures; Modeling; National Institute on Alcohol Abuse and Alcoholism; Natural experiment; New York; New York City; Not Hispanic or Latino; Outcome; Pamphlets; Parents; Population; Post-Traumatic Stress Disorders; Quality of life; Race; Randomized; Randomized Controlled Trials; Recording of previous events; Research; Resources; Risk; SARS-CoV-2 infection; Sample Size; Sampling; Standardization; Stress; Telephone; Time; Veterans; Waxes; alcohol abuse therapy; alcohol measurement; alcohol related consequences; alcohol seeking behavior; alcohol use disorder; base; behavioral economics; brief intervention; cohort; drinking; economic impact; efficacy evaluation; efficacy testing; experience; follow-up; improved; novel; prospective; racial difference; racial disparity; recruit; resilience; response; social; social media; volunteer

The COVID-19 pandemic has major implications for alcohol use and treatment utilization for alcohol use disorder (AUD), and there are pronounced racial disparities in COVID-19 experiences including higher rates of COVID-19 infections, hospitalizations, and deaths in Blacks, serving as the foci of this COVID-19 supplement. More specifically, this supplement covers the final 2 years of a 4-year randomized controlled trial (RCT) to examine the efficacy of a one-session phone intervention, Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS), to increase AUD treatment utilization and reduce drinking. Subjects are adult volunteers with AUD recruited from the Rochester, New York area through social media who have no prior history of AUD treatment. Following a baseline assessment, subjects are randomized to CBT-TS or a control condition (being read an information pamphlet on AUD treatment) and followed for 6 months. One year into recruitment for the RCT, in March 2020, a statewide executive order was issued in response to the COVID-19 pandemic that swept into New York City, with sudden and dramatic effects throughout the state. A month later, the study team began to administer a detailed assessment of COVID-19 experiences to assess subjects' personal exposure to COVID- 19, exposure of family members, stress related to COVID-19, and alcohol use affected by COVID-19. Through this supplement, these data at the population level (marked by the executive order) and at the individual level (obtained through the COVID-19 assessment) are used to analyze COVID-19 related experiences and their prospective associations with AUD treatment utilization, drinking outcomes, and response to the study intervention (Specific Aim 1) and to explore racial disparities through comparisons of Blacks and white non- Hispanics (Specific Aim 2). Moreover, pilot research suggests that Blacks may be especially responsive to the CBT-TS intervention, underscoring the importance of further study of the intervention in this population. To achieve the two study aims, the supplement provides resources to increase the length of follow-up (from 6 months to 12 months) which is needed to model effects of COVID-19 experiences over time, and to increase the sample size (from n=450 to n=500), with a priority on increased recruitment of Blacks (to reach n=100) to facilitate sub-analyses and comparisons with white non-Hispanics. This supplement is in response to NOT-OD- 20-097 and addresses the emphases in the NOSI on “downstream health impacts resulting from (COVID-19 related) social, behavioral, and economic impacts, including (race) differences in risk and resiliency.” Moreover, it is responsive to its call for “active grants studying existing longitudinal cohorts, particularly those cohorts with considerable data relevant to COVID-19 social and behavioral factors prior and subsequent to the (COVID-19) outbreak.” Along these lines, the statewide executive order was issued at the midpoint of data collection, optimal for the examination of the cohort before and after exposure to COVID-19.

COVID-19大流行对酒精使用和酒精使用的治疗利用产生重大影响 疾病（AUD），并且在COVID-19的经历中存在明显的种族差异，包括较高的 黑人的COVID-19感染、住院和死亡，作为本COVID-19补充的重点。 更具体地说，本补充材料涵盖了4年随机对照试验（RCT）的最后2年， 检查一次电话干预的有效性，寻求治疗的认知行为疗法 （CBT-TS），以增加AUD治疗利用率并减少饮酒。受试者为患有AUD的成年志愿者 通过社交媒体从纽约地区的罗切斯特招募，既往无AUD治疗史。 在基线评估之后，将受试者随机分配至CBT-TS或对照条件（被读取为对照条件）。 关于AUD治疗的信息小册子），并随访6个月。RCT招募一年后， 2020年3月，为应对席卷加州的COVID-19疫情，该州发布了一项行政命令。 纽约市，整个州的突然和戏剧性的影响。一个月后，研究小组开始 对COVID-19经历进行详细评估，以评估受试者的COVID个人暴露- 19、家庭成员的暴露、与COVID-19相关的压力以及受COVID-19影响的酒精使用。通过 这一补充，这些数据在人口层面（由行政命令标记）和个人层面 （通过COVID-19评估获得）用于分析COVID-19相关经验及其 与AUD治疗利用、饮酒结局和对研究的反应的前瞻性关联 干预（具体目标1），并通过比较黑人和白色非 西班牙裔（具体目标2）。此外，试点研究表明，黑人可能特别敏感， CBT-TS干预，强调了进一步研究该人群干预的重要性。到 为了实现这两个研究目标，补充材料提供了资源，以增加随访时间（从6 这需要对COVID-19经历随时间的影响进行建模，并增加 样本量（从n=450到n=500），优先增加黑人招募（达到n=100）， 便于亚组分析和与非西班牙裔白色人的比较。这一补充是为了回应NOT-OD- 20-097，并解决了NOSI中关于“COVID-19造成的下游健康影响”的重点 相关）社会，行为和经济影响，包括（种族）风险和弹性的差异。 此外，它还响应了其呼吁，“积极赠款研究现有的纵向队列，特别是那些 队列中有大量与COVID-19社会和行为因素相关的数据， （COVID-19）爆发。”沿着这些路线，全州范围的行政命令是在数据的中点发布的 收集，最适合于暴露于COVID-19之前和之后的队列检查。