A lifecourse approach to women's mental health: from fertility to perimenopause

项目总结/摘要 不孕症及其治疗往往是长期的，可能会在心理上具有挑战性。因此，许多 女性报告说，当她们尝试时，会感到痛苦、失控、社会孤立和耻辱感。 无法成功怀孕。然而，人们对生育能力受损对长期生育能力的影响知之甚少。 长期心理健康结果。有限的纵向数据存在的关联，受损的生育能力， 焦虑和抑郁症状在怀孕、产后和中年的轨迹。此外，本发明还 虐待、缺乏社会支持、经济困难和种族主义经历等困难是众所周知的 与抑郁症和焦虑症的症状密切相关，但这些因素如何与抑郁症和焦虑症相互作用， 妇女在其整个生命过程中生育能力受损的经历尚不清楚。 该多样性补充将为候选人Pérez Capotosto博士提供额外的经验， 专业知识，技能和必要的数据，以促进她的目标，成为一个独立的护士科学家在该领域 生育能力受损的人Pérez Capotosto博士将利用她的背景和经验来研究这些影响。 对长期心理健康的影响。具体来说，她将调查 与无生育障碍病史的女性相比，有生育障碍病史的女性的抑郁和焦虑 生育能力受损的相关性，以及整个生育能力受损妇女中抑郁和/或焦虑的相关性， 寿命在这样做的过程中，她将研究早期生活困难的影响，如虐待的历史，缺乏 社会支持、经济困难和种族主义经历对抑郁和焦虑的影响 在生育能力受损的妇女中。已在Project Viva队列中收集了该提案的数据 通过“妇女心脏代谢和骨骼健康的生命周期方法：从生育到围绝经期” （5 R 01 HD 096032 -03），父母补助金。作为父母补助金的PI，艾米丽奥肯博士和豪尔赫·查瓦罗博士 将指导佩雷斯·卡波托斯托博士候选人还将获得安·沃尔伯特·伯吉斯博士的指导， 心理健康护理学教授。波士顿大学康奈尔护理学院。与 培训，技能，和经验，她将通过拟议的多样性补充，佩雷斯博士 Capotosto打算从临床学术职位转向研究学术职位。

Project Summary/Abstract Infertility and its treatments are often long-lasting and can be psychologically challenging. Consequently, many women report feelings of distress, loss of control, social isolation, and a sense of stigma as they try unsuccessfully to achieve pregnancy. However, little is known about the effects of impaired fertility on long- term mental health outcomes. Limited longitudinal data exist on the associations of impaired fertility with trajectories of anxiety and depressive symptoms across pregnancy, postpartum, and mid-life. Additionally, hardships such as abuse, lack of social support, financial hardship, and the experiences of racism are known to be strongly associated with symptoms of depression and anxiety, yet how these factors interact with the experience of impaired fertility in women across their life course is not known. This Diversity Supplement will provide the candidate, Dr. Pérez Capotosto, with the additional experience, expertise, skills, and data necessary to facilitate her goal to become an independent nurse scientist in the field of impaired fertility. Dr. Pérez Capotosto will draw upon her background and experience to examine the effects of impaired fertility on long-term mental health outcomes. Specifically, she will investigate the associations of depression and anxiety among women with a history of impaired fertility compared to women without a history of impaired fertility, and the relevance of depression and/or anxiety in women with impaired fertility throughout the lifespan. In doing so, she will examine the effects of early life hardship, such as the history of abuse, lack of social support, financial hardship, and experiences of racism, on the associations of depression and anxiety among women with impaired fertility. Data for this proposal have been collected in the Project Viva cohort through, “A lifecourse approach to women's cardiometabolic and bone health: from fertility to perimenopause” (5R01HD096032-03), the parent grant. As the PIs of the parent grant, Dr. Emily Oken and Dr. Jorge Chavarro will mentor Dr. Pérez Capotosto. The candidate will also receive mentorship from Dr. Ann Wolbert Burgess, a Professor of Psychiatric Mental Health Nursing in the W.F. Connell School of Nursing at Boston College. With the training, skills, and experience she will receive through the proposed diversity supplement, Dr. Pérez Capotosto intends to move from a clinical academic position to a research academic position.