Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adults

护士健康研究 3：年轻人多次暴露环境流行病学队列

• 批准号: 10440077
• 负责人: Jorge Eduardo Chavarro
• 金额: $ 5.9万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440077
• 关键词: 2019-nCoV; Address; Administrative Supplement; Adolescence; Area; Big Data Methods; Biological; Blood; COVID-19 testing; Canada; Characteristics; Chronic Disease; Collection; Data; Data Collection; Diet; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Risk Factor; Environmental and Occupational Exposure; Feces; Female; Individual; Infection; Infrastructure; Infrastructure Activities; Investigation; Knowledge; Life Cycle Stages; Measurement; Menopause; Modernization; Monoclonal Antibody R24; Nurses' Health Study; Online Systems; Parents; Participant; Physical activity; Pregnancy; Pregnancy Histories; Prospective cohort study; Psychosocial Factor; Research; Research Personnel; Resources; Risk Factors; Role; SARS-CoV-2 antibody; Sampling; Specimen; Symptoms; Technology; Technology Assessment; Time; Uncertainty; United States; Urine; Vial device; cohort; cost effective; disorder risk; experience; geographic risk; innovation; mobile computing; novel; operation; parent project; prospective; residence; sample collection; young adult

PROJECT SUMMARY OF PARENT PROJECT (R24ES028521) This is an R24 application to support the infrastructure of our environmental epidemiology cohort, Nurses’ Health Study 3 (NHS3), an open, prospective, web-based cohort (www.nhs3.org). Participants are residence of the United States and Canada born after 1965. Most of the female participants (89%) have enrolled before menopause and 41% of female participants and 62% ofmale participants have no prior pregnancy history. In this innovative web-based study, we have been collecting detailed information on personal characteristics and potential disease risk factors every 6 months, including diet, physical activity, psychosocial factors, and a wide variety of occupational and environmental exposures. Data collection has focused on current exposures, as well as those experienced during adolescence, prior to first pregnancy, and during pregnancy.Discoveries made in NHS3 will build on the knowledge and experience gained from earlier cohorts on the impacts of the environment on chronic disease risk but takes advantage of modern technology to collect novel prospective data during important windows of exposure across the life course. The NHS3 investigators have substantial experience in environmental epidemiology,exposure assessment, and Big Data analytics, as well as in managing and maintaining large prospective cohort studies. This cohort provides a unique opportunity to address key outstanding questions in environmental epidemiology, by collecting highly detailed information on multiple environmental exposures at key points in the life course. The R24 supports infrastructure activities in the expanded NHS3 cohort thatmaximize the existing resources and broaden the current scope of research, to allow the investigation of multiple environmental exposures. We will focus our efforts in three main areas: 1) the expansion of study operations and maximization of existing resources, 2) the collection of environmental exposure samples, and 3) expansion of web-based mobile technologies and assessment of spatial uncertainty and measurement error. We have partnered with U01HL145386 to collect biologic samples (blood, urine, stool) concurrently with the environment exposure samples. This administrative supplement will allow us to prepare cost-effective lab-ready vials of both biologic and environmental specimens at the time of collection.

母项目项目总结（r24es028521）

项目成果

Occupational exposure to high-level disinfectants and risk of miscarriage among nurses.

• DOI: 10.1136/oemed-2020-107297
• 发表时间: 2021-10
• 期刊: Occupational and environmental medicine
• 影响因子: 4.9
• 作者: Ding M;Lawson C;Johnson C;Rich-Edwards J;Gaskins AJ;Boiano J;Henn S;Rocheleau C;Chavarro JE
• 通讯作者: Chavarro JE

Occupational use of high-level disinfectants and asthma incidence in early- to mid-career female nurses: a prospective cohort study.

• DOI: 10.1136/oemed-2020-106793
• 发表时间: 2021-04
• 期刊: Occupational and environmental medicine
• 影响因子: 4.9
• 作者: Dumas O;Gaskins AJ;Boggs KM;Henn SA;Le Moual N;Varraso R;Chavarro JE;Camargo CA Jr
• 通讯作者: Camargo CA Jr

Demographic and behavioural correlates of energy drink consumption.

• DOI: 10.1017/s1368980022001902
• 发表时间: 2023-07
• 期刊: PUBLIC HEALTH NUTRITION
• 影响因子: 3.2
• 作者: Markon, Andre O.;Ding, Ming;Chavarro, Jorge E.;Wolpert, Beverly J.
• 通讯作者: Wolpert, Beverly J.