Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adults

PAGINE项目（R24ES028521）的项目总结 这是一个R24应用程序，用于支持我们的环境流行病学队列的基础设施， 护士健康研究3（NHS3），一个开放的，前瞻性的，基于网络的队列（www.nhs3.org）。 参赛者均为1965年以后出生的美国和加拿大居民。大多数女性 参与者（89%）在绝经前登记，41%的女性参与者和62%的男性参与者 受试者无既往妊娠史。在这项基于网络的创新研究中，我们 每6天收集个人特征和潜在疾病风险因素的详细信息 月，包括饮食，体力活动，心理社会因素，以及各种职业 和环境暴露。数据收集的重点是目前的风险，以及那些 在青春期、第一次怀孕前和怀孕期间经历的。 NHS 3将建立在从早期队列中获得的关于以下影响的知识和经验的基础上： 环境对慢性病风险的影响，但利用现代技术收集新的 在整个生命过程中重要的暴露窗口期间的前瞻性数据。NHS 3 调查人员在环境流行病学、暴露评估和 大数据分析，以及管理和维护大型前瞻性队列研究。这 群组提供了一个独特的机会，以解决关键的突出问题，在环境 流行病学，通过收集关于多种环境暴露的非常详细的信息， 生命历程中的关键点。 R24支持扩展的NHS 3队列中的基础设施活动， 资源和拓宽目前的研究范围，让调查的多个 环境暴露。我们将集中力量在三个主要方面：1）扩大研究 运营和现有资源的最大化，2）收集环境暴露 3）扩大基于网络的移动的技术和评估空间不确定性 测量误差。我们与U01HL145386合作收集生物样本（血液， 尿液、粪便）与环境暴露样品同时进行。这一行政补充将 使我们能够在实验室准备具有成本效益的生物和环境样本小瓶， 收集的时间。

PROJECT SUMMARY OF PARENT PROJECT (R24ES028521) This is an R24 application to support the infrastructure of our environmental epidemiology cohort, Nurses’ Health Study 3 (NHS3), an open, prospective, web-based cohort (www.nhs3.org). Participants are residence of the United States and Canada born after 1965. Most of the female participants (89%) have enrolled before menopause and 41% of female participants and 62% ofmale participants have no prior pregnancy history. In this innovative web-based study, we have been collecting detailed information on personal characteristics and potential disease risk factors every 6 months, including diet, physical activity, psychosocial factors, and a wide variety of occupational and environmental exposures. Data collection has focused on current exposures, as well as those experienced during adolescence, prior to first pregnancy, and during pregnancy.Discoveries made in NHS3 will build on the knowledge and experience gained from earlier cohorts on the impacts of the environment on chronic disease risk but takes advantage of modern technology to collect novel prospective data during important windows of exposure across the life course. The NHS3 investigators have substantial experience in environmental epidemiology,exposure assessment, and Big Data analytics, as well as in managing and maintaining large prospective cohort studies. This cohort provides a unique opportunity to address key outstanding questions in environmental epidemiology, by collecting highly detailed information on multiple environmental exposures at key points in the life course. The R24 supports infrastructure activities in the expanded NHS3 cohort thatmaximize the existing resources and broaden the current scope of research, to allow the investigation of multiple environmental exposures. We will focus our efforts in three main areas: 1) the expansion of study operations and maximization of existing resources, 2) the collection of environmental exposure samples, and 3) expansion of web-based mobile technologies and assessment of spatial uncertainty and measurement error. We have partnered with U01HL145386 to collect biologic samples (blood, urine, stool) concurrently with the environment exposure samples. This administrative supplement will allow us to prepare cost-effective lab-ready vials of both biologic and environmental specimens at the time of collection.