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Long-term health consequences of birth by cesarean section

剖腹产分娩的长期健康后果

基本信息

批准号：
9768538
负责人：
Jorge Eduardo Chavarro
金额：
$ 66.97万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9768538
关键词：
Address Adipose tissue Adolescence Adolescent and Young Adult Adult Age Asthma Biological Biological Markers Birth Body Composition Body mass index Breast Breast Cancer Risk Factor Cardiovascular Diseases Cardiovascular system Cesarean section Child Childhood Cholesterol Chronic Chronic Disease Colorectal DNA Methylation Data Dual-Energy X-Ray Absorptiometry Enrollment Evaluation Fatty acid glycerol esters Fetus Frequencies Glucose Health High Density Lipoprotein Cholesterol IGFBP3 gene Immune Individual Infant Inflammation Insulin Insulin Resistance Insulin-Like Growth Factor I Interleukin-6 Intervention Knowledge Leptin Life Link Malignant Neoplasms Maternal Mortality Measures Mediating Medical Morbidity - disease rate Mothers Newborn Infant Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Pattern Perinatal mortality demographics Pregnancy Pregnant Women Premature Mortality Professional Organizations Prostate Puberty Public Health Resources Risk Risk Factors Savings Stimulation of Cell Proliferation Triglycerides Umbilical Cord Blood United States Vagina Vaginal delivery procedure Vitamin D Woman Work abdominal fat adipokines adiponectin adult obesity antenatal blood lipid cancer biomarkers cancer risk cardiometabolic risk cohort cost disorder risk experience genome-wide glucose metabolism gut microbiome gut microbiota high risk inflammatory marker insight interest lipid metabolism maternal morbidity methylation pattern microbiota profiles mortality obesity in children obesity risk offspring perinatal morbidity peripheral blood randomized trial recruit respiratory sex stool sample whole genome

项目摘要

ABSTRACT Nearly 1.3 million cesareans are performed each year, resulting in the birth of one third of all children nationwide. When indicated, cesarean sections reduce morbidity and mortality to mother and fetus. However, many cesareans do not have a clear medical indication leading to an increase in serious maternal and perinatal morbidity and mortality. Increasing evidence also suggests that risks to offspring may extend to chronic-non communicable conditions. Consistent evidence shows that individuals born by cesarean are at an increased risk of obesity as children and that higher rates of obesity persist through adult life, raising the possibility that the long-term health consequences of being born by cesarean may extend to an increased risk of obesity-related chronic conditions including common cancers (breast, prostate, colorectal), cardiovascular disease and type 2 diabetes. However, data on the association of birth by cesarean with risk factors for or biomarkers of chronic disease risk remains scarce. There is also a paucity of information regarding the biologic mechanisms underlying the relation between cesarean delivery and offspring chronic disease risk. This proposal addresses these knowledge gaps. Specifically, we propose to evaluate the relation of birth by cesarean with pubertal onset –an established risk factor for breast cancer; with longitudinal trajectories in biomarkers of chronic disease risk –including markers of mitogenesis, inflammation, insulin resistance, lipid metabolism and adipose tissue activity; and with longitudinal trajectories in body composition (Aims 1 and 2). In addition, we propose to evaluate the relation of birth by cesarean section with longitudinal trajectories in whole genome DNA methylation patterns and gut microbiome (Aims 3 and 4) in order to gain further understanding on the biological underpinnings of the long-term health consequences of birth by cesarean.

摘要