Long-term health consequences of birth by cesarean section

剖腹产分娩的长期健康后果

基本信息

  • 批准号:
    9768538
  • 负责人:
  • 金额:
    $ 66.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-01 至 2023-06-30
  • 项目状态:
    已结题

项目摘要

ABSTRACT Nearly 1.3 million cesareans are performed each year, resulting in the birth of one third of all children nationwide. When indicated, cesarean sections reduce morbidity and mortality to mother and fetus. However, many cesareans do not have a clear medical indication leading to an increase in serious maternal and perinatal morbidity and mortality. Increasing evidence also suggests that risks to offspring may extend to chronic-non communicable conditions. Consistent evidence shows that individuals born by cesarean are at an increased risk of obesity as children and that higher rates of obesity persist through adult life, raising the possibility that the long-term health consequences of being born by cesarean may extend to an increased risk of obesity-related chronic conditions including common cancers (breast, prostate, colorectal), cardiovascular disease and type 2 diabetes. However, data on the association of birth by cesarean with risk factors for or biomarkers of chronic disease risk remains scarce. There is also a paucity of information regarding the biologic mechanisms underlying the relation between cesarean delivery and offspring chronic disease risk. This proposal addresses these knowledge gaps. Specifically, we propose to evaluate the relation of birth by cesarean with pubertal onset –an established risk factor for breast cancer; with longitudinal trajectories in biomarkers of chronic disease risk –including markers of mitogenesis, inflammation, insulin resistance, lipid metabolism and adipose tissue activity; and with longitudinal trajectories in body composition (Aims 1 and 2). In addition, we propose to evaluate the relation of birth by cesarean section with longitudinal trajectories in whole genome DNA methylation patterns and gut microbiome (Aims 3 and 4) in order to gain further understanding on the biological underpinnings of the long-term health consequences of birth by cesarean.
摘要

项目成果

期刊论文数量(0)
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Jorge Eduardo Chavarro其他文献

Jorge Eduardo Chavarro的其他文献

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{{ truncateString('Jorge Eduardo Chavarro', 18)}}的其他基金

Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adults
护士健康研究 3:年轻人多次暴露环境流行病学队列
  • 批准号:
    10440077
  • 财政年份:
    2021
  • 资助金额:
    $ 66.97万
  • 项目类别:
Childhood and Adult Psychosocial Stress and the Association with Disparities in Adult Cardiometabolic Health
儿童和成人心理社会压力以及与成人心脏代谢健康差异的关联
  • 批准号:
    10478317
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:
Changes in Dietary Supplement Use During the COVID-19 Pandemic
COVID-19 大流行期间膳食补充剂使用的变化
  • 批准号:
    10281619
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research
整合生命历程方法、生物学和数字表型以支持心肺疾病流行病学研究
  • 批准号:
    10620840
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:
A lifecourse approach to women's cardiometabolic and bone health: from fertility to perimenopause
女性心脏代谢和骨骼健康的生命全程方法:从生育到围绝经期
  • 批准号:
    10378551
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:
A lifecourse approach to women's cardiometabolic and bone health: from fertility to perimenopause
女性心脏代谢和骨骼健康的生命全程方法:从生育到围绝经期
  • 批准号:
    10728449
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:
A lifecourse approach to women's cardiometabolic and bone health: from fertility to perimenopause
女性心脏代谢和骨骼健康的生命全程方法:从生育到围绝经期
  • 批准号:
    9975867
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research
整合生命历程方法、生物学和数字表型以支持心肺疾病流行病学研究
  • 批准号:
    10116455
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research
整合生命历程方法、生物学和数字表型以支持心肺疾病流行病学研究
  • 批准号:
    10487390
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:
A lifecourse approach to women's mental health: from fertility to perimenopause
女性心理健康的生命全程方法:从生育到围绝经期
  • 批准号:
    10621562
  • 财政年份:
    2019
  • 资助金额:
    $ 66.97万
  • 项目类别:

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