ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing

ITEST：扩大青少年友好的艾滋病毒自我检测的创新工具

• 批准号: 10619291
• 负责人: OLIVER CHUKWUJEKWU EZECHI
• 金额: $ 23.72万
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10619291
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adherence; Adolescent; Adopted; Advocate; Award; Awareness; Clinic; Clinical; Country; Development; Educational workshop; Ethics; Feedback; Foundations; Government Officials; Guidelines; HIV; HIV Infections; Incidence; Individual; Infrastructure; Institutes; Intervention; Interview; Knowledge; Medical Research; Mentors; Methodology; Methods; National Institute of Child Health and Human Development; Nigeria; Nigerian; North Carolina; Oral; Outcome; Ownership; Parents; Participant; Persons; Phase; Population; Prevention; Prevention Guidelines; Prevention strategy; Process; Quasi-experiment; Randomized Controlled Trials; Research; Research Priority; Research Support; Resource Sharing; Resources; Risk; Series; Testing; Training; United States National Institutes of Health; Universities; World Health Organization; Youth; age group; base; civil society; community based participatory research; community engagement; cost; crowdsourcing; data resource; design; experience; implementation outcomes; implementation research; implementation science; implementation strategy; innovation; interest; lectures; low and middle-income countries; meetings; multidisciplinary; pre-exposure prophylaxis; prevent; prevention service; primary outcome; programs; response; secondary outcome; self testing; service delivery; skills; social stigma; standard of care; testing uptake; tool; uptake; working group

Abstract The proposed supplement is within scope of Specific Aims 1 and 2 in our parent ITEST study (UH3HD096929). The supplement focus on the same participant population (AYA in Nigeria), use the same conceptual framework (youth participatory action research), uses the same methodologies (crowdsourcing open calls), adopts the same focus on implementation science, and similarly will help to decrease HIV incidence among at-risk AYA. Our findings from initial AYA crowdsourcing activities in Nigeria suggested that AYA had limited understanding of PrEP. In 2020, there were few PrEP demonstration projects or national guidance that recommended the use of PrEP. As a result, our randomized controlled trial did not have PrEP uptake as a secondary outcome and did not focus on PrEP. However, there have been four major recent shifts that provide a unique opportunity to now focus on PrEP and inform Nigerian national PrEP use among AYA: (1) There are now more demonstration projects focused on PrEP among at- risk individuals, including adolescents (REFS); (2) the national Nigerian HIV prevention guidelines explicitly recommend the use of PrEP;4 (3) youth-led community engagement programs conducted by our UH3 project demonstrate that AYA are interested and willing to start PrEP (REFS); (4) excellent rates of linkage from HIV self-testing into youth-friendly clinics and STD testing from our UH3 study suggest that this could be a feasible mechanism to organize HIV prevention services for at-risk Nigerian AYA. The proposed supplement logically builds on the foundation from the 2021 crowdsourcing open call and 2022 designathon which both focused on ways to enhance PrEP uptake among AYA in Nigeria. We will draw on the strong resources, infrastructure, and relationships that have been developed in the initial phases of this study. The proposed supplement will be led by the Nigerian Institute of Medical Research and supported by St. Louis University and the University of North Carolina at Chapel Hill, the three key partners which led the parent UH3 study. Our skills, experience, and knowledge make our team uniquely qualified to organize this research.

抽象的 所提出的补充剂在我们的父母Itest研究中的特定目标1和2范围内 （UH3HD096929）。该补充侧重于同一参与者（尼日利亚的AYA）， 使用相同的概念框架（青年参与式行动研究），使用相同 方法论（众包公开电话），采用同样的专注于实施科学， 同样，将有助于降低高危AYA之间的艾滋病毒发病率。我们的发现从初始 尼日利亚的AYA众包活动建议AYA对PREP的了解有限。 在2020年，很少有准备演示项目或国家指导 使用准备。结果，我们的随机对照试验没有作为一个 次要结果，不关注准备。但是，最近有四个主要 现在提供了一个独特机会的转变，现在专注于准备并通知尼日利亚国家准备 在AYA中使用：（1）现在有更多的示威项目，重点是 风险个人，包括青少年（参考）； （2）预防尼日利亚国家艾滋病毒 指南明确建议使用PREP; 4（3）青年领导的社区参与 我们的UH3项目进行的计划表明，AYA有兴趣并愿意开始 准备（参考）； （4）从艾滋病毒自我测试到对青年友好型诊所和 我们UH3研究中的性病测试表明，这可能是组织的可行机制 高危尼日利亚AYA的艾滋病毒预防服务。拟议的补充在逻辑上建立 2021年众包公开电话和2022年Designathon的基础 专注于增强尼日利亚AYA的准备吸收的方法。我们将借鉴强者 在此的初始阶段已经建立的资源，基础架构和关系 学习。拟议的补充剂将由尼日利亚医学研究所和 在圣路易斯大学和北卡罗来纳大学教堂山的支持下，三个 领导父母UH3研究的主要合作伙伴。我们的技能，经验和知识使我们 团队具有独特的资格来组织这项研究。