ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing

摘要 拟议的补充资料属于我们母公司ITEST研究的具体目标1和2的范围 (UH3HD096929)。该补编侧重于相同的参与者人口(尼日利亚的Aya)， 使用相同的概念框架(青年参与性行动研究)，使用相同的 方法论(众包开放呼叫)，采用同样关注实施科学的方法， 同样，这将有助于降低高危人群中艾滋病毒的发病率。我们最初的调查结果 Aya在尼日利亚的众包活动表明，Aya对PrEP的了解有限。 在2020年，很少有PrEP示范项目或国家指南建议 PrEP的使用。因此，我们的随机对照试验没有将PrEP摄取作为 次要结果，没有关注PrEP。然而，最近有四个主要的 转变提供了一个独特的机会，现在专注于PrEP并向尼日利亚国家PrEP提供信息 在Aya中的用途：(1)现在有更多的示范项目集中在PrEP- 风险个人，包括青少年(参考文献)；(2)尼日利亚国家艾滋病毒预防 指南明确建议使用PrEP；4(3)青年主导的社区参与 我们的UH3项目进行的项目表明，Aya有兴趣并愿意开始 准备工作(参考文献)；(4)从艾滋病毒自我检测到对青年友好的诊所和 我们UH3研究中的STD检测表明，这可能是一种可行的组织机制 为高危尼日利亚人Aya提供的艾滋病毒预防服务。拟议的补编在逻辑上是建立在 从2021年众包开放呼吁和2022年指定的基础上 重点介绍了如何提高尼日利亚阿亚人对PrEP的认识。我们将吸纳强者 资源、基础设施和在此项目的初始阶段发展起来的关系 学习。拟议的补充方案将由尼日利亚医学研究所牵头， 在圣路易斯大学和北卡罗来纳大学教堂山分校的支持下，三人 领导母公司UH3研究的主要合作伙伴。我们的技能、经验和知识使我们的 唯一有资格组织这项研究的团队。

Abstract The proposed supplement is within scope of Specific Aims 1 and 2 in our parent ITEST study (UH3HD096929). The supplement focus on the same participant population (AYA in Nigeria), use the same conceptual framework (youth participatory action research), uses the same methodologies (crowdsourcing open calls), adopts the same focus on implementation science, and similarly will help to decrease HIV incidence among at-risk AYA. Our findings from initial AYA crowdsourcing activities in Nigeria suggested that AYA had limited understanding of PrEP. In 2020, there were few PrEP demonstration projects or national guidance that recommended the use of PrEP. As a result, our randomized controlled trial did not have PrEP uptake as a secondary outcome and did not focus on PrEP. However, there have been four major recent shifts that provide a unique opportunity to now focus on PrEP and inform Nigerian national PrEP use among AYA: (1) There are now more demonstration projects focused on PrEP among at- risk individuals, including adolescents (REFS); (2) the national Nigerian HIV prevention guidelines explicitly recommend the use of PrEP;4 (3) youth-led community engagement programs conducted by our UH3 project demonstrate that AYA are interested and willing to start PrEP (REFS); (4) excellent rates of linkage from HIV self-testing into youth-friendly clinics and STD testing from our UH3 study suggest that this could be a feasible mechanism to organize HIV prevention services for at-risk Nigerian AYA. The proposed supplement logically builds on the foundation from the 2021 crowdsourcing open call and 2022 designathon which both focused on ways to enhance PrEP uptake among AYA in Nigeria. We will draw on the strong resources, infrastructure, and relationships that have been developed in the initial phases of this study. The proposed supplement will be led by the Nigerian Institute of Medical Research and supported by St. Louis University and the University of North Carolina at Chapel Hill, the three key partners which led the parent UH3 study. Our skills, experience, and knowledge make our team uniquely qualified to organize this research.