GTReal Workshop: Real-Time Methods in Electrophysiology

GTReal 研讨会：电生理学中的实时方法

• 批准号: 7106264
• 负责人: John A. White
• 金额: $ 1.8万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106264
• 关键词: electrophysiology; neurophysiology; time resolved data; travel; voltage /patch clamp; workshop

DESCRIPTION (provided by applicant): The 2nd annual GTReal workshop will be held in May or June 2006 at the campus of Boston University. The meeting will be attended by around 120 scientists at a range of levels of experience (students, postdoctoral fellows, faculty members). The meeting will include 3 invited speakers, 12-15 contributed talks, and 2-4 "breakout" sessions, in which attendees will discuss topics of mutual interest. There will also be a hands-on tutorials. Depending on the number of submissions, there may be posters as well. Following on the success of the first event, held in May 2005 at the Georgia Tech, GTReal will focus on the following topics: (1) Exchanging scientific results. Because of the technical hurdles involved, only a handful of investigators are using real-time "dynamic clamp" systems to mimic membrane conductances in excitable cells. These investigators have gone to this level of trouble because dynamic clamp techniques provide the best method to test specific, computationally based hypotheses in living systems. Invited and contributed talks will focus on exciting examples of dynamic clamp and other real-time applications in neurophysiology and other disciplines, as well as technical means used to obtain such results. (2) Building a community of developers and end-users. Over a decade after the seminal work on dynamic clamp, no turn-key system exists, but several groups have devised systems that seem promising. A major goal of the breakout sessions will be to continue to build a community of developers and end-users of real-time technology, based on the principles of open-source software development. The attendees of GTReal will constitute much of the core of this community. Tutorials and informal interactions will add to the cadre of skilled users and developers. (3) Extending the real-time approach to new types of experiments. Real-time techniques allow an unprecedented degree of quantitative hypothesis testing in biological experiments. A number of extensions of the technique would increase its impact dramatically. For example, within cellular neurophysiology, it should be possible to combine real-time technology and optical techniques for recording and stimulation. Real-time techniques also have the potential to revolutionize systems physiology and behavioral studies of sensory systems.

描述（由申请人提供）：第二届年度GTReal研讨会将于2006年5月或6月在波士顿大学校园举行。大约120名经验丰富的科学家（学生、博士后研究员、教职员工）将出席会议。会议将包括3名特邀演讲者，12-15个贡献的演讲，以及2-4个“分组”会议，与会者将讨论共同感兴趣的话题。也将有一个动手教程。根据提交的数量，也可能有海报。继2005年5月在格鲁吉亚理工学院成功举办第一次活动之后，GTReal将重点关注以下主题：（1）交流科学成果。由于涉及的技术障碍，只有少数研究人员使用实时“动态钳”系统来模拟可兴奋细胞的膜电导。这些研究人员之所以会遇到这种麻烦，是因为动态钳技术提供了在生命系统中测试特定的、基于计算的假设的最佳方法。邀请和贡献的会谈将集中在神经生理学和其他学科的动态钳和其他实时应用的令人兴奋的例子，以及用于获得这些结果的技术手段。(2)建立开发人员和最终用户的社区。在动态夹的开创性工作十多年后，还没有出现交钥匙系统，但几个小组已经设计出了似乎很有前途的系统。分组会议的一个主要目标将是根据开放源码软件开发的原则，继续建立一个实时技术开发人员和最终用户社区。GTReal的与会者将构成这个社区的核心。教程和非正式的交互将增加熟练用户和开发人员的骨干。(3)将实时方法扩展到新类型的实验。实时技术允许在生物实验中进行前所未有的定量假设检验。该技术的一些扩展将大大增加其影响。例如，在细胞神经生理学中，应该可以将联合收割机实时技术和光学技术结合起来进行记录和刺激。实时技术也有可能彻底改变系统生理学和感觉系统的行为研究。