COBRE: U NEL: ADMIN: NEBRASKA REDOX BIOLOGY CENTER

COBRE：U NEL：管理员：内布拉斯加州氧化还原生物中心

• 批准号: 8360525
• 负责人: Donald F Becker
• 金额: $ 75.87万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360525
• 关键词: Applied Research; Area; Award; Basic Science; Biological Sciences; Biology; Biomedical Research; Cataract; Centers of Research Excellence; Collaborations; Communities; Core Facility; Country; Disease; Ensure; Faculty; Funding; Grant; Human Resources; Individual; Institution; International; Intervention; Link; Malignant Neoplasms; Medical center; Mentors; National Center for Research Resources; Nebraska; Nerve Degeneration; Oxidation-Reduction; Pathologic Processes; Physiological Processes; Principal Investigator; Program Development; Reaction; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientist; Source; Therapeutic; United States National Institutes of Health; Universities; cost; member; neuroimmunology; programs; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The Redox Biology Center (RBC), established in 2002 with IDeA program funds as an interdisciplinary partnership between University of Nebraska-Lincoln and University of Nebraska Medical Center scientists, is building a nationally visible and internationally recognized program of excellence in redox biology that spans basic and applied sciences. The Center's objectives are to enhance Nebraska's biomedical research capacity by creating a strategically linked infrastructure of strong research programs in redox biology and to mentor a cadre of talented junior faculty to independent success. In the years since its inception, the Center has developed a national presence in redox biology and completed its original objectives. The RBC has changed the biomedical research landscape in Nebraska, energizing a shift in the research culture toward interdisciplinary, thematic, collaborative research (e.g., a new area of study  redox neuroimmunology  has resulted from Center collaborations) and has garnered exceptional institutional support as is evidenced by an institution-wide Program of Excellence award in 2006. Our continuation proposal details our plan to continue building the capacity needed to ensure national prominence and international recognition. The specific aims that will drive the Center over the next five years are to: 1) maintain and broaden (by inclusion of a Co-Director) the RBC's administrative core of personnel and programs that support and enhance the Center's research; 2) develop existing faculty through the support of five thematically-linked primary research projects, a strong mentoring program for junior investigators, and support of two essential core facilities and pilot research projects; 3) increase research capacity through targeted recruitment of five researchers in key areas of redox biology; and 4) graduate from IDeA program funding as a self-sustainable center of research excellence in redox biology through the development of program projects and individual and collaborative research grants. The pioneering consolidation of redox-linked programs at Nebraska by the RBC represents a unique focal expertise that is, to our knowledge, not presently available elsewhere in the country. The Center's focus on redox biology is supported by a growing recognition in the life sciences community of the centrality of redox reactions in both physiological and pathological processes. Elucidation of redox-linked mechanisms in diseases, ranging from cataracts to cancers and neurodegeneration by RBC members, hold promise for developing therapeutic strategies for intervention.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（由申请人提供）：氧化还原生物学中心（RBC），成立于2002年与IDEA计划资金作为内布拉斯加州林肯大学和内布拉斯加州医学中心科学家大学之间的跨学科合作伙伴关系，正在建立一个全国可见和国际公认的卓越的氧化还原生物学计划，跨越基础和应用科学。 该中心的目标是通过建立一个强大的氧化还原生物学研究项目的战略联系基础设施，提高内布拉斯加州的生物医学研究能力，并指导一批有才华的初级教师独立取得成功。 自成立以来，该中心已在氧化还原生物学方面建立了全国性的存在，并完成了其最初的目标。 RBC改变了内布拉斯加州的生物医学研究格局，推动了研究文化向跨学科、主题、合作研究的转变（例如，新的研究领域  氧化还原神经免疫学  由于中心的合作），并已获得特殊的机构支持，这是证明了2006年的一个机构范围的卓越计划奖。 我们的延续提案详细说明了我们继续建设确保国家突出地位和国际承认所需能力的计划。 在未来五年中，该中心的具体目标是：1）保持和扩大（通过包括一名联合主任）RBC的行政核心人员和项目，支持和加强中心的研究; 2）通过支持五个主题相关的主要研究项目，为初级研究人员提供强有力的指导计划，支持两个重要的核心设施和试点研究项目; 3）通过有针对性地招聘五名氧化还原生物学关键领域的研究人员来提高研究能力;和4）从IDEA计划资助毕业，作为一个自我-通过发展项目和个人及合作研究赠款，在氧化还原生物学方面建立可持续的卓越研究中心。 RBC在内布拉斯加州率先整合了与氧化还原相关的项目，这是一种独特的焦点专业知识，据我们所知，目前在美国其他地方还没有。 该中心对氧化还原生物学的关注得到了生命科学界对氧化还原反应在生理和病理过程中的中心地位的日益认识的支持。 阐明从白内障到癌症和红细胞成员神经变性等疾病中与氧化还原相关的机制，有望开发干预治疗策略。