COBRE: U NEL: ADMIN: NEBRASKA REDOX BIOLOGY CENTER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 描述(由申请者提供)：氧化还原生物学中心(RBC)成立于2002年，由IDEA项目基金建立，是内布拉斯加州大学林肯分校和内布拉斯加大学医学中心科学家之间的跨学科合作伙伴关系，正在建设一个覆盖基础科学和应用科学的全国知名和国际公认的氧化还原生物学卓越项目。该中心的目标是通过在氧化还原生物学方面建立一个强大的研究项目的战略联系的基础设施来提高内布拉斯加州的生物医学研究能力，并指导一批有才华的初级教员取得独立成功。在成立以来的几年里，该中心在氧化还原生物学领域形成了全国性的存在，并完成了最初的目标。RBC改变了内布拉斯加州的生物医学研究格局，推动了研究文化向跨学科、主题、协作研究的转变(例如，氧化还原神经免疫学的一个新研究领域是中心合作的结果)，并获得了特殊的机构支持，2006年全机构卓越计划奖就证明了这一点。 我们的延续提案详细说明了我们继续建设确保国家地位和国际认可所需的能力的计划。中心未来五年的具体目标是：1)保持和扩大(通过包括一名联席主任)加拿大皇家银行支持和加强中心研究的人员和计划的行政核心；2)通过支持五个主题相关的初步研究项目、针对初级调查人员的强有力的指导计划以及支持两个基本核心设施和先导研究项目来发展现有教员；3)通过有针对性地招聘五名氧化还原生物学关键领域的研究人员来提高研究能力；以及4)从IDEA项目基金中毕业，成为氧化还原生物学领域自我可持续的卓越研究中心，通过开发项目项目和个人和合作研究拨款。 加拿大皇家银行开创性地整合了内布拉斯加州与氧化还原相关的项目，这代表了一种独特的重点专业知识，据我们所知，这是目前在美国其他地方无法获得的。该中心对氧化还原生物学的关注得到了生命科学界日益认识到氧化还原反应在生理和病理过程中的中心地位的支持。从白内障到癌症和RBC成员的神经变性等疾病中氧化还原相关机制的阐明，有望为干预措施制定治疗策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The Redox Biology Center (RBC), established in 2002 with IDeA program funds as an interdisciplinary partnership between University of Nebraska-Lincoln and University of Nebraska Medical Center scientists, is building a nationally visible and internationally recognized program of excellence in redox biology that spans basic and applied sciences. The Center's objectives are to enhance Nebraska's biomedical research capacity by creating a strategically linked infrastructure of strong research programs in redox biology and to mentor a cadre of talented junior faculty to independent success. In the years since its inception, the Center has developed a national presence in redox biology and completed its original objectives. The RBC has changed the biomedical research landscape in Nebraska, energizing a shift in the research culture toward interdisciplinary, thematic, collaborative research (e.g., a new area of study  redox neuroimmunology  has resulted from Center collaborations) and has garnered exceptional institutional support as is evidenced by an institution-wide Program of Excellence award in 2006. Our continuation proposal details our plan to continue building the capacity needed to ensure national prominence and international recognition. The specific aims that will drive the Center over the next five years are to: 1) maintain and broaden (by inclusion of a Co-Director) the RBC's administrative core of personnel and programs that support and enhance the Center's research; 2) develop existing faculty through the support of five thematically-linked primary research projects, a strong mentoring program for junior investigators, and support of two essential core facilities and pilot research projects; 3) increase research capacity through targeted recruitment of five researchers in key areas of redox biology; and 4) graduate from IDeA program funding as a self-sustainable center of research excellence in redox biology through the development of program projects and individual and collaborative research grants. The pioneering consolidation of redox-linked programs at Nebraska by the RBC represents a unique focal expertise that is, to our knowledge, not presently available elsewhere in the country. The Center's focus on redox biology is supported by a growing recognition in the life sciences community of the centrality of redox reactions in both physiological and pathological processes. Elucidation of redox-linked mechanisms in diseases, ranging from cataracts to cancers and neurodegeneration by RBC members, hold promise for developing therapeutic strategies for intervention.