COBRE: U NEL: ADMIN: NEBRASKA REDOX BIOLOGY CENTER

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 描述（由申请人提供）：氧化还原生物学中心 (RBC) 于 2002 年由 IDeA 计划资金建立，作为内布拉斯加大学林肯分校和内布拉斯加大学医学中心科学家之间的跨学科合作伙伴关系，正在建立一个全国可见且国际认可的跨基础科学和应用科学的氧化还原生物学卓越计划。 该中心的目标是通过在氧化还原生物学方面建立一个战略性联系的强大研究项目基础设施来增强内布拉斯加州的生物医学研究能力，并指导一批有才华的初级教师取得独立成功。 自成立以来，该中心已在全国范围内发展了氧化还原生物学领域并完成了其最初的目标。 RBC 改变了内布拉斯加州的生物医学研究格局，促进了研究文化向跨学科、专题、协作研究的转变（例如，中心合作产生了氧化还原神经免疫学的新研究领域），并获得了特殊的机构支持，2006 年全机构卓越计划奖就证明了这一点。 我们的持续提案详细说明了我们继续建设确保国家知名度和国际认可所需能力的计划。 未来五年推动该中心的具体目标是： 1) 维持和扩大（通过包括一名联合主任）RBC 的行政核心人员和项目，以支持和加强该中心的研究； 2）通过支持五个主题相关的初级研究项目、针对初级研究人员的强有力的指导计划以及支持两个重要的核心设施和试点研究项目来发展现有师资队伍； 3）通过有针对性地招募五名氧化还原生物学关键领域的研究人员来提高研究能力； 4) 通过开发项目以及个人和合作研究资助，获得 IDeA 项目资助，成为氧化还原生物学领域自我可持续的卓越研究中心。 加拿大皇家银行在内布拉斯加州开创性地整合氧化还原相关项目，代表了独特的焦点专业知识，据我们所知，目前该国其他地方还没有这种专业知识。 该中心对氧化还原生物学的关注得到了生命科学界日益认识到氧化还原反应在生理和病理过程中的中心地位的支持。 红细胞成员对白内障、癌症和神经退行性疾病等疾病中氧化还原相关机制的阐明，为制定干预治疗策略带来了希望。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The Redox Biology Center (RBC), established in 2002 with IDeA program funds as an interdisciplinary partnership between University of Nebraska-Lincoln and University of Nebraska Medical Center scientists, is building a nationally visible and internationally recognized program of excellence in redox biology that spans basic and applied sciences. The Center's objectives are to enhance Nebraska's biomedical research capacity by creating a strategically linked infrastructure of strong research programs in redox biology and to mentor a cadre of talented junior faculty to independent success. In the years since its inception, the Center has developed a national presence in redox biology and completed its original objectives. The RBC has changed the biomedical research landscape in Nebraska, energizing a shift in the research culture toward interdisciplinary, thematic, collaborative research (e.g., a new area of study  redox neuroimmunology  has resulted from Center collaborations) and has garnered exceptional institutional support as is evidenced by an institution-wide Program of Excellence award in 2006. Our continuation proposal details our plan to continue building the capacity needed to ensure national prominence and international recognition. The specific aims that will drive the Center over the next five years are to: 1) maintain and broaden (by inclusion of a Co-Director) the RBC's administrative core of personnel and programs that support and enhance the Center's research; 2) develop existing faculty through the support of five thematically-linked primary research projects, a strong mentoring program for junior investigators, and support of two essential core facilities and pilot research projects; 3) increase research capacity through targeted recruitment of five researchers in key areas of redox biology; and 4) graduate from IDeA program funding as a self-sustainable center of research excellence in redox biology through the development of program projects and individual and collaborative research grants. The pioneering consolidation of redox-linked programs at Nebraska by the RBC represents a unique focal expertise that is, to our knowledge, not presently available elsewhere in the country. The Center's focus on redox biology is supported by a growing recognition in the life sciences community of the centrality of redox reactions in both physiological and pathological processes. Elucidation of redox-linked mechanisms in diseases, ranging from cataracts to cancers and neurodegeneration by RBC members, hold promise for developing therapeutic strategies for intervention.