Physiology of bacterial metabolism in the human gut microbiome
人类肠道微生物群中细菌代谢的生理学
基本信息
- 批准号:10623328
- 负责人:
- 金额:$ 39.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-02 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AcidsAminesBacteriaBacterial PhysiologyButyratesChromosome MappingDiseaseFutureGeneticGenetic DeterminismGrowthHealthHumanIndolesKnowledgeLightLinkMetabolicMetabolic ControlMetabolic PathwayMetabolismMicrobeNatureNutrientNutritional RequirementsOutputPathway interactionsPharmaceutical PreparationsPhysiologyPlayProcessRoleSecureTechniquesVolatile Fatty Acidsbacterial geneticsbacterial metabolismcommensal bacteriadietarydrug productiongenome-widegut bacteriagut microbiomegut microbiotainsightmetabolic abnormality assessmentmetabolomicsmicrobialmicrobiomesmall moleculetooltrimethylamine
项目摘要
Summary:
One of the biggest gaps in our knowledge of the human gut microbiome is how microbes secure the energy
and nutrients required to sustain their growth. This is an important deficit in light of the fact that microbial
pathways produce short chain fatty acids like butyrate, indoles like indolepropionic acid, and amines like
trimethylamine, all of which play a critical role in host physiology and disease. Understanding the metabolic
processes that underlie why microbes make these molecules is critical for developing strategies to predictably
control the metabolic output of the gut microbiota.
Despite the importance of microbial metabolism in the gut to human physiology, we know very little about the
nature of these metabolic pathways. A key gap in knowledge is how pathways for high abundance metabolites
is linked to the physiology of commensal bacteria. Knowledge of these metabolic strategies is critical to
developing strategies aimed at predictably modulating the metabolic output of the gut microbiota. One of the
major challenges to studying the gut microbiota is that genetic tools are only available for a small subset of
bacteria. Therefore, new tools are urgently needed to study the physiology and metabolism of genetically
intractable microbes.
In this project, we will use techniques in bacterial physiology and genetics to uncover how microbes in the gut
capture energy from dietary nutrients, and how these processes contribute to drug-like small molecules that
influence host physiology. We will also develop a new metabolomics approach to generate genome-wide maps
of genetic determinants of microbial small molecules in genetically tractable and intractable gut bacteria. These
studies will provide fundamental insights into several of the microbiome's core functions and will stimulate
future avenues for inquiry into the human gut microbiome.
简介:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dylan Dodd其他文献
Dylan Dodd的其他文献
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{{ truncateString('Dylan Dodd', 18)}}的其他基金
Microbiota-based probiotics to treat inborn errors in metabolism
基于微生物群的益生菌可治疗先天性代谢缺陷
- 批准号:
10365689 - 财政年份:2022
- 资助金额:
$ 39.73万 - 项目类别:
Microbiota-based probiotics to treat inborn errors in metabolism
基于微生物群的益生菌可治疗先天性代谢缺陷
- 批准号:
10574622 - 财政年份:2022
- 资助金额:
$ 39.73万 - 项目类别:
Physiology of bacterial metabolism in the human gut microbiome
人类肠道微生物群中细菌代谢的生理学
- 批准号:
10460570 - 财政年份:2021
- 资助金额:
$ 39.73万 - 项目类别:
Physiology of bacterial metabolism in the human gut microbiome
人类肠道微生物群中细菌代谢的生理学
- 批准号:
10686712 - 财政年份:2021
- 资助金额:
$ 39.73万 - 项目类别:
Physiology of bacterial metabolism in the human gut microbiome
人类肠道微生物群中细菌代谢的生理学
- 批准号:
10275848 - 财政年份:2021
- 资助金额:
$ 39.73万 - 项目类别:
Modulation of gut bacteria-derived host metabolites
肠道细菌衍生的宿主代谢物的调节
- 批准号:
9453251 - 财政年份:2018
- 资助金额:
$ 39.73万 - 项目类别:
Biochemical Characterization of Specificity for Family 3 Glycoside Hydrolases
家族 3 糖苷水解酶特异性的生化表征
- 批准号:
8212226 - 财政年份:2010
- 资助金额:
$ 39.73万 - 项目类别:
Biochemical Characterization of Specificity for Family 3 Glycoside Hydrolases
家族 3 糖苷水解酶特异性的生化表征
- 批准号:
7936105 - 财政年份:2010
- 资助金额:
$ 39.73万 - 项目类别:
Biochemical Characterization of Specificity for Family 3 Glycoside Hydrolases
家族 3 糖苷水解酶特异性的生化表征
- 批准号:
7753991 - 财政年份:2010
- 资助金额:
$ 39.73万 - 项目类别:
Biochemical Characterization of Specificity for Family 3 Glycoside Hydrolases
家族 3 糖苷水解酶特异性的生化表征
- 批准号:
8387025 - 财政年份:2010
- 资助金额:
$ 39.73万 - 项目类别:
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