Evaluating a Multilevel Communication Campaign to Increase HIV Vaccine Trial Enrollment

项目摘要/摘要 艾滋病毒疫苗试验网络(HVTN)在招募 参与艾滋病毒疫苗早期临床试验。参与的巨大障碍 在HVTN预防性艾滋病毒早期试验中，包括缺乏艾滋病毒公共紧迫性的许多 研究访问、长期随访、疫苗诱导的血清阳性反应和艾滋病毒污名， 导致在招募参与者参加这些试验方面遇到了重大挑战。我们将共同提炼 现有媒体活动、开发、测试和评估多层次沟通 战略，以解决这些关键问题，并加强我们的声誉 受艾滋病毒影响不成比例的边缘化社区的可信度 增加他们参加艾滋病毒疫苗早期试验的人数。在未来的7年里， HVTN将把重点放在早期阶段的试验计划上，以推动油田的发展并确定 高效有效的产品，用于以后的药效测试。这将需要 制定和部署基于证据的战略，以打击虚假信息和 加强社区参与。我们的团队和我们的临床研究站点 网络与不同的利益攸关方建立了长期的社区伙伴关系。 在我们为美国政府资助的新冠肺炎疫苗临床进行的第三阶段临床试验期间 试验我们开发了新的策略来补充我们的社区参与计划： (1)以消费者为主导的市场推广和广告活动；。(2)虚拟大会堂和 听证会议；以及(3)使用专家小组审查协议并提供 指引和方向。我们将在这项工作的基础上，为我们的艾滋病毒战略提供信息。我们 组建了一支由不同研究人员组成的经验丰富的团队，以实现以下目标： 1)确定影响艾滋病毒疫苗试验的初始媒体宣传活动的组成部分 注册并制定多层次的沟通策略；2)评估 第一阶段艾滋病毒疫苗试验注册的多层次沟通战略；以及3) 确定多层次沟通策略是否会产生公众参与 疫苗和疫苗试验。这个项目将是第一个大规模的传播研究 在美国进行，以提高社区的意识和参与度 与艾滋病毒疫苗试验研究。它将评估错误信息和与此有关的参与 为目前和未来的艾滋病毒疫苗试验招募提供信息的战略，预计将 通过制定改善多样性的强有力的战略，对健康产生积极的影响， 公平，并纳入第一阶段预防性艾滋病毒疫苗试验。

Project Summary/Abstract The HIV Vaccine Trials Network (HVTN) has experienced significant challenges recruiting participants in early-stage HIV vaccine clinical trials. Formidable barriers to participation in HVTN preventive HIV early phase trials, including lack of HIV public urgency, numerous study visits, long-term follow-up, vaccine induced seropositivity and HIV stigma, have resulted in significant challenges enrolling participants into these trials. We will co-refine an existing media campaign, develop, test and evaluate a multilevel communication strategy to address some of these crucial concerns and strengthen our reputation of trustworthiness in marginalized communities disproportionately affected by HIV to increase their enrollment into early-stage HIV vaccine trials. Over the next 7 years, the HVTN will focus on the early phase trial program to move the field forward and to identify products efficiently and effectively for later efficacy testing. This will require the development and deployment of evidence-based strategies to combat misinformation and to strengthen community engagement. Our team and the clinical research sites in our Network have forged longstanding community partnerships with diverse stakeholders. During our phase 3 clinical trials for the US government-funded COVID-19 vaccine clinical trials we developed new strategies to supplement our community engagement program: (1) a consumer-driven marketing and advertising campaign; (2) virtual town halls and listening sessions; and (3) the use of expert panels to review protocols and provide guidance and direction. We will build on this work to inform our HIV strategy. We assembled an experienced team of diverse researchers to accomplish the following aims: 1) Identify components of an initial media campaign that impact HIV vaccine trial registration and develop a multilevel communication strategy; 2) Evaluate the impact of the multilevel communication strategy on Phase I HIV vaccine trial registration; and 3) Determine if the multilevel communication strategy generates public engagement with vaccines and vaccine trials. This project will be the first large-scale communication study conducted in the United States to improve community awareness of and engagement with HIV vaccine trial research. It will assess misinformation and engagement with this strategy to inform current and future HIV vaccine trials recruitment and is expected to have a positive health impact by establishing robust strategies to improve diversity, equity, and inclusion in Phase 1 preventive HIV vaccine trials.