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Fetal Programming of Growth and Obesity: A Metabolomics Approach

胎儿生长和肥胖的编程：代谢组学方法

基本信息

批准号：
10627605
负责人：
Yeyi Zhu
金额：
$ 4.74万
依托单位：
KAISER FOUNDATION RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2023-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10627605
关键词：
Adult Affect Age Area Bioinformatics Biological Biological Markers Biometry Birth Body mass index Branched-Chain Amino Acids California Cardiometabolic Disease Caucasians Child Clinical Complement Data Data Collection Diet Dietary Factors Elderly Electronic Health Record Environment Epidemiology Etiology Fasting Fatty Acids Fetal Growth First Pregnancy Trimester Foundations Functional disorder Gestational Age Glucose Goals Growth Human Impairment Individual Infant Inositol Insulin Integrated Health Care Systems Investigation K-Series Research Career Programs Knowledge Length Life Life Style Measurement Measures Mentorship Metabolic Metabolic Pathway Metabolism Nonesterified Fatty Acids Obesity Obesity Epidemic Overnutrition Overweight Pathway interactions Phenotype Physical activity Predisposition Pregnancy Prevention Preventive Prospective cohort Psychosocial Assessment and Care Research Research Personnel Resources Risk Sampling Second Pregnancy Trimester Serum Shapes Small for Gestational Age Infant Solid Source Surveys Technology Training Training Programs Validation Weight Whole Organism Work acylcarnitine aged base cardiometabolic risk career comorbidity dietary experience fetal fetal programming follow-up gut microbiota hands-on learning high risk human data in utero indexing individualized prevention infancy metabolomics mitochondrial dysfunction multi-racial multidisciplinary novel nutrition obesity in children obesity prevention obesity risk offspring personalized care prenatal exposure programs prospective public health priorities racial and ethnic response sample collection stem tool trimethyloxamine

项目摘要

PROJECT SUMMARY/ABSTRACT This K01 Career Development Award proposes a multidisciplinary 4-year training program to provide the candidate, Dr. Yeyi Zhu, with the experience and resources necessary to launch a successful career as an independent investigator to elucidate early origins of obesity and related comorbidities. The childhood obesity epidemic remains an urgent public health priority. Early prevention is critical to stemming the tide of obesity. Yet, our ability to identify promising prevention targets has been impeded by the difficulty in measuring the holistic metabolic status by conventional tools. Several human studies, including from Dr. Zhu's previous work, indicate that individual exposures including dietary factors in pregnancy may program obesity risk in later life. However, the underlying metabolic pathways are elusive. To fill this important knowledge gap, Dr. Zhu will use a novel holistic framework that leverages both targeted and untargeted metabolomics approach, the state-of- the-art electronic health records (EHR) data, and bioinformatics analytics to investigate the mechanisms by which the in-utero environment may infer risk of fetal growth extremes [small for gestational age (SGA) or large for gestational age (LGA)] and altered infant growth trajectories and excess adiposity (weight-for-length or body- mass-index-for-age z-score ≥85th percentile). This application takes advantage of the Pregnancy Environment and Lifestyle Study within Kaiser Permanente Northern California, with unique, robust resources of fasting serum specimens collection in early to mid-pregnancy, anthropometric measurements, multi-domain survey data (e.g., diet, physical activity, psychosocial assessments), and EHR data throughout the gestation and offspring infancy. The specific aims, to be examined in a sample of 150 LGA, 150 SGA, and 150 appropriate for gestational age births, are to: examine the associations between candidate (branch-chain amino acids, myo-inositol, trimethylamine N-oxide, acylcarnitines, and fatty acids) and untargeted metabolites in early to mid-pregnancy with fetal growth extremes (Aim 1) and infant growth trajectories and excess adiposity from 0-2 years (Aim 2), and explore metabolomic signatures for dietary factors in utero (Aim 3). Study findings may elucidate the underlying metabolic pathways and potential upstream preventive targets related to modifiable in- utero exposures, such as maternal dietary factors, to mitigate childhood obesity. Dr. Zhu is well suited to perform this research: 1) she has a solid foundation in epidemiology, nutrition, and biostatistics; 2) this K01 will significantly broaden her repertoire of advanced training in metabolomics, bioinformatics, and related biological interpretation; and 3) she has leveraged a carefully coordinated set of resources including a multidisciplinary mentorship committee, coursework, and applied learning closely aligned with the training objectives and specific aims. This K01 is essential to advance her long-term career objective of becoming an independent investigator with expertise in omics and bioinformatics to study early origins of cardiometabolic disease, with the ultimate goal to inform individualized care for upstream prevention of obesity and its comorbidities.

项目总结/文摘

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Longitudinal Plasma Metabolomics Profile in Pregnancy-A Study in an Ethnically Diverse U.S. Pregnancy Cohort.

DOI：
10.3390/nu13093080
发表时间：
2021-09-01
期刊：
Nutrients
影响因子：
5.9
作者：
Mitro SD;Wu J;Rahman ML;Cao Y;Zhu Y;Chen Z;Chen L;Li M;Hinkle SN;Bremer AA;Weir NL;Tsai MY;Song Y;Grantz KL;Gelaye B;Zhang C
通讯作者：
Zhang C

Plasma Acylcarnitines during Pregnancy and Neonatal Anthropometry: A Longitudinal Study in a Multiracial Cohort.

DOI：
10.3390/metabo11120885
发表时间：
2021-12-17
期刊：
Metabolites
影响因子：
4.1
作者：
Song Y;Lyu C;Li M;Rahman ML;Chen Z;Zhu Y;Hinkle SN;Chen L;Mitro SD;Li LJ;Weir NL;Tsai MY;Zhang C
通讯作者：
Zhang C

Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies-Singletons Cohort.