NIH Training Grant in the Chemistry-Biology Interface

项目摘要：该化学-生物界面(CBI)培训计划的目标是准备18 博士前学生将成为生物医学科学领域的下一代科学家。这个目标将是 通过招收顶尖学生并培训他们进行跨学科研究、批判性思维、 写作和交流，以及负责任的研究行为。其他不同的组件 方案是：a)在CBI举办关于尖端研究的课程，b)关于企业家精神、智力的讲习班 物业管理和网络，以及c)参与同行主导的团队学习(PLTL)体验， 这将进一步丰富学员的技能和专业准备。该计划将直接 受益于艺术、科学和工程之间密切的研究关系和物理上的接近 (AS&E)和罗切斯特大学医学与牙科学院(SMD)，其成立 在将科学发现转化为新业务的创新和创业方面的记录。该计划 包括从AS&E的六个部门和方案中挑选的33名优秀教官(16名教官) 和SMD(17)，他们都有部门内和部门间在研究和 为活动提供建议。该计划的一个中心主题，正如教士们的研究兴趣所共享的那样，是 开发基础知识和战略，以支持生成、开发和交付 预防和治疗人类疾病的新型治疗剂。学员将在以下方面进行研究 围绕这一统一主题的四个主要领域之一：合成化学、药物发现和交付、药物 目标识别和传感以及生物分子的结构和功能。项目总监和两位 副主任将由一个由三名额外教员组成的指导委员会提供协助。加州调查局 学员将从参与部门中最优秀的学生中挑选出来，并特别强调 关于通过外联活动扩大受训人员的多样性，招募多样化的申请者，并保留 并在该项目中培养学生。新的CBI实习生将在博士课程的第二年开始，并将 参加CBI核心课程，一个负责任的研究行为课程，一个有效的课程 写作和交流。所有受训人员将制定和实施个人发展计划， 至少参加一次专业发展研讨会，每年邀请并主持2名研讨会演讲者， 组织和参加年度静修，每月参加CBI午餐，讨论建议的话题。 按团体进行。在博士课程的第四年，学员将担任CBI课程的PLTL研讨会负责人， 继续进行职业发展，并在CBI静修会上发表演讲。学员还将完成和 为他们的论文辩护，由33名项目导师中的一人监督。预计完成这项任务的学生 该计划将为在生命和生物医学科学领域追求各种职业做好准备。 这一计划的成功还将取决于学员的多样性和申请者人数的增加。

PROJECT SUMMARY: The goal of this Chemistry-Biology Interface (CBI) training program is to prepare 18 predoctoral students to become next-generation scientists in the biomedical sciences. This goal will be achieved through recruiting top students and training them in cross-disciplinary research, critical thinking, writing and communication, and the responsible conduct of research. Other distinctive components of the program are: a) a course on cutting-edge research at the CBI, b) workshops on entrepreneurship, intellectual property management, and networking, and c) participation in Peer-Led Team Learning (PLTL) experiences, which will further enrich the skillset and professional preparation of the trainees. The program will directly benefit from the close research relationship and physical proximity between Arts, Sciences, & Engineering (AS&E) and the School of Medicine and Dentistry (SMD) at the University of Rochester, and its established record in innovation and entrepreneurial translation of scientific discoveries into new businesses. The program includes 33 outstanding preceptors chosen from six departments and programs within AS&E (16 preceptors) and SMD (17), all of whom have a strong record of intra- and interdepartmental interactions in research and advising activities. A central theme of the program, as shared by the research interests of the preceptors, is the development of fundamental knowledge and strategies to support the generation, development, and delivery of new therapeutic agents for the prevention and treatment of human diseases. Trainees will conduct research in one of the four main areas around this unifying theme: Synthetic Chemistry, Drug Discovery & Delivery, Drug Target Identification and Sensing, and Structure and Function of Biomolecules. The Program Director and two Deputy Directors will be aided by a Steering Committee comprising three additional faculty members. The CBI trainees will be drawn from the strongest students in the participating departments, with a particular emphasis on expanding trainee diversity through outreach activities, recruiting a diverse pool of applicants, and retaining and nurturing students in the program. New CBI trainees will start in Year 2 of their PhD program and will participate in the core CBI course, a course on responsible conduct of research, and a course on effective writing and communication. All trainees will develop and implement Individual Development Plans (IDPs), participate in at least one professional development workshop, invite and host 2 seminar speakers per year, organize and participate in an annual retreat, and engage in monthly CBI lunches to discuss topics suggested by the group. In Year 4 of their PhD program, trainees will serve as PLTL workshop leaders for CBI courses, continue in professional development, and present a talk at the CBI retreat. Trainees also will complete and defend their theses supervised by one of the 33 program mentors. It is expected that students completing this program will be exceptionally well prepared to pursue a variety of careers in the life and biomedical sciences. Success in this program will also be determined by increased diversity of trainees and in the pool of applicants.