Project 4 - HAALSI National

项目 4 - HAALSI 国家

• 批准号: 10627335
• 负责人: David J Canning
• 金额: $ 52.64万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627335
• 关键词: Africa; African; Age Years; Aging; Algorithms; Asian; Biological Assay; Biological Markers; Blood; COVID-19 impact; Calibration; Cognition; Cognitive; Collection; Color; Communities; Comparative Study; Complex; Consensus; Country; Data; Data Collection; Data Set; Dementia; Diagnosis; Dryness; Education; Environment; Family; Family Study; Family health status; Future; Goals; Health; Health Surveys; Health and Retirement Study; Household; Impaired cognition; Income; Individual; International; Labor Migrations; Language; Living Standards; Longitudinal Studies; Longitudinal cohort; Measurement; Measures; Mental Health; Methods; Neighborhoods; Network Infrastructure; Nonrespondent; Outcome; Patient Recruitments; Persons; Pilot Projects; Policy Making; Population; Population Group; Population Research; Prevalence; Protocols documentation; Research; Research Personnel; Rural; Sampling; Selection Bias; Sister; Site; Socioeconomic Status; South Africa; South African; Spottings; Surveys; Testing; biomarker validation; cognitive ability; cognitive function; cognitive testing; cohort; comparative; experience; follow-up; health care service utilization; health economics; health inequalities; healthy aging; improved; innovation; insight; instrument; member; mild cognitive impairment; prediction algorithm; programs; response; rural area; socioeconomics; therapy development

Project 4: HAALSI National—Abstract We propose to add a nationally representative cohort to the existing Agincourt sample of the Health and Aging in Africa: Longitudinal Study in South Africa (HAALSI) Program, allowing us to conduct the first nationally representative study of cognitive function and dementia in South Africa. Our broad array of health and socio-economic measures will be collected from a national cohort, making ours the first study from a Sub- Saharan African country to be included in the international family of Health and Retirement Studies (HRS) and allowing comparative research between HAALSI and HRS sister studies. We will conduct a national Harmonized Cognitive Assessment Protocol (HCAP) study to establish a reliable algorithm to give estimates of mild cognitive impairment (MCI) and dementia prevalence. We will measure the prevalence of cognitive impairment and dementia in South Africa and examine how it relates to socioeconomic status (SES). We will determine how the cognition-SES gradient varies for different measures of SES and investigate the underlying reasons for any differences. A goal of our study is to produce and quickly disseminate data for public use by researchers both in South Africa and internationally. A major advantage of our study will be our ability to expand the HAALSI Program’s breadth and depth, by combining the results of the national survey with the more detailed community results from the HAALSI Agincourt cohort and the detailed cognition studies embedded in that cohort. In Aim 1, we will recruit participants and collect the first wave of data for the HAALSI National cohort, a nationally representative longitudinal cohort of 4500 people 40 years of age and older (and their partners), to study healthy aging and cognition in South Africa. The detailed HCAP battery is administered to a subcohort which allows us to derive predictive algorithms for ascertainment of MCI and dementia in the full National cohort. In Aim 2, we will estimate the rate of cognitive impairment in our National cohort and investigate how cognitive ability varies by SES in South Africa. In Aim 3, we will study the generalizability of estimates of the determinants of cognitive decline, MCI, and dementia from the Agincourt community to the National level and pilot extending the survey to additional communities in the South African Population Research Infrastructure Network (SAPRIN). Impact: This project will extend the HAALSI Program to the national level in South Africa to produce insights that will inform policymaking and the development of interventions to support healthy aging.

项目4：HAALSI国家摘要 我们建议在现有的阿金库尔卫生和人口普查样本中增加一个具有全国代表性的队列， 非洲老龄化：南非纵向研究（HAALSI）计划，使我们能够进行第一次 南非认知功能和痴呆症的全国代表性研究。我们广泛的健康 和社会经济措施将收集从一个国家的队列，使我们的第一个研究从一个小组， 撒哈拉非洲国家将被纳入健康和退休研究国际大家庭， 允许HAALSI和HRS姐妹研究之间的比较研究。我们将进行一次全国性的 协调认知评估协议（HCAP）研究，以建立一种可靠的算法， 轻度认知障碍（MCI）和痴呆患病率。我们将测量认知障碍的患病率 在南非的损伤和痴呆症，并研究它如何与社会经济地位（SES）。我们将 确定如何认知SES梯度不同措施的SES和调查的基础 任何差异的原因。我们研究的一个目标是通过以下方式产生和快速传播供公众使用的数据： 研究人员在南非和国际。我们研究的一个主要优势是我们能够 扩大HAALSI计划的广度和深度，通过结合全国调查的结果， 来自HAALSI阿金库尔队列的更详细的社区结果和详细的认知研究 嵌入到这个队列中。在目标1中，我们将为HAALSI招募参与者并收集第一波数据 国家队列，一个全国代表性的4500人40岁及以上的纵向队列（和 他们的合作伙伴），在南非研究健康老龄化和认知。管理详细的HCAP组合 到一个子队列，使我们能够推导出预测算法，用于全面确定MCI和痴呆症。 全国队列。在目标2中，我们将估计我们国家队列中认知障碍的发生率， 调查南非社会经济地位如何影响认知能力。在目标3中，我们将研究 从Agincourt社区到2010年，认知能力下降、MCI和痴呆症的决定因素估计 在国家一级和试点范围内将调查扩大到南非其他社区 研究基础设施网络。影响：该项目将把HAALSI计划扩展到 在南非国家一级，提出见解，为决策和发展提供信息， 支持健康老龄化的干预措施。