Multimodal Delineation of Neurodegenerative Mechanisms
Multimodal Delineation of Neurodegenerative Mechanisms
批准号:
10628096
负责人:
Sreeganga S Chandra
金额:
$16.14万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-07-01 至 2028-06-30
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
The goal of this proposal is to train the next generation of scientists that will advance our understanding of
Alzheimer’s Disease and Related Dementias (ADRD) at Yale University, and to fulfil the promise of developing
disease-modifying therapeutics for these debilitating conditions. The rationale of this program is to take an
integrated approach to understand the diversity and similarities of ADRD conditions as well as their co-morbidity,
using cell biology, structural biology, pathology, biostatistics, and clinical medicine. Twenty nine (29) faculty from
twelve (12) basic and clinical departments at Yale School of Medicine and Yale College are participants in this
multidisciplinary program. The program offers both depth and breadth. The depth derives from the expertise of
the faculty investigating ADRDs and the many institutional resources that can be brought to bear including, an
Alzheimer’s Disease Research Center (ADRC), a Parkinson’s Foundation Research Center, three Aligning
Science Across Parkinson’s (ASAP) teams, a recently instituted Center for Human Brain Discovery brain bank,
and a new research building where most mentors will co-locate. The breadth of the program derives from the
diversity of approaches being used to tackle these diseases ranging from genetics to drug development. Mentors
are Ph.Ds. and M.D.s. with substantial NIH support and NIA/NINDS related research foci. Faculty investigate all
major forms of dementia, including Alzheimer’s disease (AD), Frontotemporal Dementia (FTLD), Lewy Body
Dementia (LBD), and Vascular contributions to cognitive impairment and dementia (VCID). Methodologies
include deep sequencing; transcriptomics; proteomics; cell and induced pluripotent stem cell (iPSC) culture;
immunohistochemistry; electron and advanced light microscopy; biochemistry and molecular analyses; structural
biology; rodent, monkey behavior; and fMRI and PET imaging in human subjects. Six predoctoral positions are
requested. Trainees are selected by the Executive Committee from an outstanding pool of advanced
Neuroscience and Biology graduate students (3rd and 4th year), which are amongst the best in the country and
come from a variety of backgrounds in the sciences. Trainees are selected based on their potential for
excellence, leadership in research as well as their diverse backgrounds. Training includes focused coursework,
instruction in experimental design and statistical methods, Clinicopathologic correlation (CPC) conferences,
thoughtful mentorship through advisory committees with oral and written feedback, structured seminar programs,
career skills development, and numerous opportunities for written and oral presentation of research progress.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Investigating the Functions of RME8 in Parkinson's Disease
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批准号:10681663
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项目类别:
-
资助金额:$25.13万
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财政年份:2023
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负责人:Sreeganga S Chandra
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依托单位:
Role of Glucosylsphingosine in Parkinson Disease and Dementia with Lewy Bodies
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批准号:10526913
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项目类别:
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资助金额:$6.37万
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财政年份:2019
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负责人:Sreeganga S Chandra
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依托单位:
Identifying the neuronal substrates of the depalmitoylating enzyme PPT1
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批准号:9111168
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项目类别:
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资助金额:$25.08万
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财政年份:2016
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负责人:Sreeganga S Chandra
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依托单位:
Identifying the neuronal substrates of the depalmitoylating enzyme PPT1
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批准号:9229080
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项目类别:
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资助金额:$20.94万
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财政年份:2016
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负责人:Sreeganga S Chandra
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依托单位:
Roles of the CSPalpha Chaperone Complex in Presynaptic Maintenance and ANCL
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批准号:8696912
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项目类别:
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资助金额:$36.46万
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财政年份:2014
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负责人:Sreeganga S Chandra
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依托单位:
Roles of the CSPalpha Chaperone Complex in Presynaptic Maintenance and ANCL
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批准号:8997541
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项目类别:
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资助金额:$36.42万
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财政年份:2014
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负责人:Sreeganga S Chandra
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依托单位:
Roles of the CSPalpha Chaperone Complex in Presynaptic Maintenance and ANCL
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批准号:9222810
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项目类别:
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资助金额:$36.42万
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财政年份:2014
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负责人:Sreeganga S Chandra
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依托单位:
The Physiological Functions of Synucleins
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批准号:8688370
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项目类别:
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资助金额:$31.61万
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财政年份:2010
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负责人:Sreeganga S Chandra
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依托单位:
The Physiological Functions of Synucleins
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批准号:8284375
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项目类别:
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资助金额:$31.93万
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财政年份:2010
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负责人:Sreeganga S Chandra
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依托单位:
The Physiological Functions of Synucleins
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批准号:7984565
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项目类别:
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资助金额:$36.2万
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财政年份:2010
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负责人:Sreeganga S Chandra
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依托单位:
The Physiological Functions of Synucleins
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批准号:8089504
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项目类别:
-
资助金额:$31.93万
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财政年份:2010
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负责人:Sreeganga S Chandra
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依托单位:
The Physiological Functions of Synucleins
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批准号:8481595
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项目类别:
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资助金额:$30.81万
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财政年份:2010
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负责人:Sreeganga S Chandra
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依托单位:
海外基金