Center for Cancer Biology Research

这是一项建立卓越生物医学研究中心（COBRE）的建议，重点是癌症生物学，重点是肿瘤特异性标记物和抗原的鉴定、功能表征和靶向。我们的中心将使用细胞和分子生物学、免疫学、纳米粒子技术和动物模型来研究人类癌症的发展、检测和治疗。包括5个研究项目。项目1 （Meena Jaggi, PhD）的目标是了解蛋白激酶Dl对（3-连环蛋白）介导的信号传导的影响，并确定PKD1表达是否通过这一途径影响肿瘤进展。在Project 2 （Kristi Egland, PhD）中，我们发现了大量在前列腺癌细胞中表达水平升高的膜和分泌蛋白。这一信息将用于开发一种新的前列腺癌诊断测试，检测患者血清中的自身抗体。项目3 （Satoshi Nagata博士）将开发一组针对表面抗原的单克隆抗体，这些抗原在B细胞恶性肿瘤中高度表达。将测试这些抗体在免疫疗法中的潜在用途。项目4 （Subhash Chauhan博士）将开发胰腺癌治疗和药物输送的新方法。目标是将放射免疫疗法和纳米颗粒技术结合起来，以高度特异性地递送细胞毒性化合物。项目5 （William Spanos， MD）将重点关注免疫反应在头颈部鳞状细胞癌治疗后肿瘤清除中的作用。一个强大的指导计划将利用一群优秀的高级教师的经验，积极的研究项目。导师将为研究设计、手稿准备、拨款申请和其他重要的职业发展方面提供指导。EAC由五名在基础、转化和临床研究方面具有广泛经验的国际知名科学家组成。研究能力将由分子病理学、流式细胞术、肿瘤生物学和成像的核心设施提供支持。招聘高素质初级调查员3名，资深调查员1名。培养学生和博士后，支持举办系列研讨会，资助癌症研究领域的试点研究项目。

This is a proposal to establish a Center of Biomedical Research Excellence (COBRE) focusing on Cancer Biology with emphasis on the identification, functional characterization, and targeting of tumor specific markers and antigens. Our center will use cell and molecular biology, immunology, nanoparticle technology, and animal models to examine the development, detection, and treatment of human cancer. Five research projects are included. The goals of Project 1 (Meena Jaggi, PhD) are to understand the effects of protein kinase Dl on (3- catenin-mediated signaling and to determine if PKD1 expression influences tumor progression through this pathway. For Project 2 (Kristi Egland, PhD) a large number of membrane and secreted proteins that are expressed at elevated levels in prostate cancer cells were identified. This information will be used to develop a new diagnostic test for prostate cancer that detects autoantibodies in patient serum. Project 3 (Satoshi Nagata, PhD) will develop a panel of monoclonal antibodies to surface antigens that are highly expressed in B cell malignancies. These antibodies will be tested for their potential use in immunotherapies. Project 4 (Subhash Chauhan, PhD) will develop novel methods of treatment and drug delivery for pancreatic cancer. The goal will be to combine radioimmunotherapy and nanoparticle technology for highly specific delivery of cytotoxic compounds. Project 5 (William Spanos, MD) will focus on the role of the immune response in tumor clearance following treatment of head and neck squamous cell carcinoma. A strong mentoring plan will take advantage of the experience of an outstanding group of senior faculty with active research programs. Mentors will provide guidance for research design, manuscript preparation, grant applications, and other crucial aspects of career development. An EAC consisting of five internationally recognized scientists with broad experience in basic, translational, and clinical research has been assembled. Research capabilities will be supported by core facilities in Molecular Pathology, Flow Cytometry, Tumor Biology, and Imaging. We will recruit 3 high quality junior investigators and 1 established investigator. We will train students and post-doctoral fellows, support a seminar series, and fund pilot research projects in the field of cancer research.