Center for Cancer Biology Research

这是一项建立生物医学卓越研究中心 (COBRE) 的提案，该中心专注于癌症生物学，重点是肿瘤特异性标志物和抗原的识别、功能表征和靶向。我们的中心将利用细胞和分子生物学、免疫学、纳米颗粒技术和动物模型来研究人类癌症的发展、检测和治疗。其中包括五个研究项目。项目1（Meena Jaggi，博士）的目标是了解蛋白激酶D1对（3-连环蛋白介导的信号传导）的影响，并确定PKD1表达是否通过该途径影响肿瘤进展。对于项目2（Kristi Egland，博士），鉴定出大量在前列腺癌细胞中以升高水平表达的膜蛋白和分泌蛋白。该信息将用于开发一种新的前列腺癌诊断测试，检测患者血清中的自身抗体。项目3 Satoshi Nagata 博士将开发一组针对 B 细胞恶性肿瘤中高表达的表面抗原的单克隆抗体，项目 4（Subhash Chauhan 博士）将开发治疗胰腺癌的新方法。一个强有力的指导计划将利用活跃研究项目的优秀资深教师团队的经验，为研究设计、稿件准备、资助申请和职业发展的其他关键方面提供指导。由五位在基础、转化和临床研究方面拥有丰富经验的国际知名科学家组成的 EAC 将得到分子病理学、流式细胞术、肿瘤生物学和肿瘤学领域的核心设施的支持。我们将招募 3 名高素质初级研究员和 1 名资深研究员，支持一系列研讨会，并资助癌症研究领域的试点研究项目。

This is a proposal to establish a Center of Biomedical Research Excellence (COBRE) focusing on Cancer Biology with emphasis on the identification, functional characterization, and targeting of tumor specific markers and antigens. Our center will use cell and molecular biology, immunology, nanoparticle technology, and animal models to examine the development, detection, and treatment of human cancer. Five research projects are included. The goals of Project 1 (Meena Jaggi, PhD) are to understand the effects of protein kinase Dl on (3- catenin-mediated signaling and to determine if PKD1 expression influences tumor progression through this pathway. For Project 2 (Kristi Egland, PhD) a large number of membrane and secreted proteins that are expressed at elevated levels in prostate cancer cells were identified. This information will be used to develop a new diagnostic test for prostate cancer that detects autoantibodies in patient serum. Project 3 (Satoshi Nagata, PhD) will develop a panel of monoclonal antibodies to surface antigens that are highly expressed in B cell malignancies. These antibodies will be tested for their potential use in immunotherapies. Project 4 (Subhash Chauhan, PhD) will develop novel methods of treatment and drug delivery for pancreatic cancer. The goal will be to combine radioimmunotherapy and nanoparticle technology for highly specific delivery of cytotoxic compounds. Project 5 (William Spanos, MD) will focus on the role of the immune response in tumor clearance following treatment of head and neck squamous cell carcinoma. A strong mentoring plan will take advantage of the experience of an outstanding group of senior faculty with active research programs. Mentors will provide guidance for research design, manuscript preparation, grant applications, and other crucial aspects of career development. An EAC consisting of five internationally recognized scientists with broad experience in basic, translational, and clinical research has been assembled. Research capabilities will be supported by core facilities in Molecular Pathology, Flow Cytometry, Tumor Biology, and Imaging. We will recruit 3 high quality junior investigators and 1 established investigator. We will train students and post-doctoral fellows, support a seminar series, and fund pilot research projects in the field of cancer research.