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Interdisciplinary Training in Auditory Neuroscience

听觉神经科学跨学科培训

基本信息

批准号：
10628888
负责人：
Edward Bartlett
金额：
$ 15.33万
依托单位：
PURDUE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628888
关键词：
Auditory Neurosciences Training

项目摘要

PROJECT SUMMARY/ABSTRACT There is a national need to advance the understanding of hearing in both healthy patients and those with various causes of hearing loss, which contribute to reduced quality of life and are correlated with much poorer health outcomes. The objective of this continuing training program is to train the next generation of faculty who will populate colleges of science, engineering, and health sciences, as well as to send graduates into industry prepared to work toward creative solutions for treating hearing loss. Specifically, in order to advance auditory neuroscience training, this graduate training program leverages faculty expertise in both basic hearing science and technology development, from three Purdue University colleges (Science, Engineering, and Health & Human Sciences) and 8 doctoral admissions programs. Two types of investigators are included: 10 hearing scientists with focused research programs related to auditory-system neuroscience, and 12 technology innovators trained in other disciplines (e.g., biomedical and electrical engineering, computer science). Collectively and collaboratively, the program expands knowledge about mechanisms at the molecular, cellular, and systems levels that underlie auditory information processing. This fundamental knowledge can then be applied to better understand the changes that lead to pathologies of the auditory system due to damage, disease, aging, and congenital disorders, as well as understanding how hearing evolved and influences behavior and natural selection. Technological approaches to these questions include, but are not limited to, super-resolution microscopy, biological implants for neuromodulation, high-resolution four-dimensional calcium imaging deep in the mammalian brain, optogenetics and robotics (automated patch-clamping) for brain circuit analysis, and multimodal brain imaging methods, coupled with advanced approaches in statistical and data analysis and model development. TPAN is unique in that it is specifically designed to serve students with undergraduate degrees in the disparate disciplines of life science, physical science or engineering, and merge them into a unified cohort focused on auditory neuroscience. Four fellows are selected for a 2-year term on the training grant, beginning at the start of their second year. The training curriculum includes 4 core courses (one each in neuroscience, the auditory periphery, central/behavioral auditory science, and signal processing), a required grant-writing course, a weekly Hearing Science seminar series where students and faculty present, and yearly attendance at extramural training courses and/or auditory-neuroscience conferences. Vertical and horizontal mentoring provide training and support at all levels, to enhance scientific networks, and to foster a sense of community among all hearing-science students (current and recent TPAN fellows, plus TPAN affiliates) that promotes success in the PhD and afterwards. Support is provided, in collaboration with Purdue's Institute for Integrative Neuroscience, for an individual data-management consultant for each Fellow, individually budgeted training-related expenses, diversity recruiting by both faculty and students, as well as for admininstrative support.

项目摘要/摘要国家有必要提高健康患者和不同疾病患者对听力的理解。听力损失的原因，这会导致生活质量下降，并与更差的健康相关结果。这一持续培训计划的目标是培养下一代将在科学、工程和健康科学学院中增加人口，并将毕业生送到工业领域准备为治疗听力损失提供创造性的解决方案。具体地说，为了推进听觉神经科学培训，这个研究生培训计划利用了教师在基础听力科学方面的专业知识和技术开发，来自普渡大学的三所学院(科学、工程和健康与人类理科)和8个博士招生计划。包括两类调查人员：10名听证科学家拥有与听觉系统神经科学相关的重点研究项目，12名技术创新者接受了培训在其他学科(例如，生物医学和电气工程、计算机科学)。集体和在协作方面，该计划扩展了关于分子、细胞和系统机制的知识听觉信息处理的基础水平。这些基本知识可以更好地应用于了解由于损伤、疾病、衰老和其他原因导致的听觉系统的病理变化先天性疾病，以及了解听力如何演变并影响行为和自然选择。解决这些问题的技术方法包括但不限于超分辨率显微镜、用于神经调节的生物植入物、高分辨率四维钙成像用于大脑电路分析的哺乳动物大脑、光遗传学和机器人(自动膜片钳)，以及多模式脑成像方法，结合统计、数据分析和模型方面的先进方法发展。TPAN的独特之处在于，它是专门为拥有以下本科学位的学生设计的生命科学、物理科学或工程学的不同学科，并将它们合并为一个统一的队列专注于听觉神经科学。四名研究员被选为为期两年的培训补助金，从他们第二年的开始。培训课程包括4门核心课程(神经科学、听觉外科学、中枢/行为听觉科学和信号处理)，一个必需的赠款撰写课程，每周一次的听力科学研讨会系列，学生和教职员工出席，每年出席校外培训课程和/或听神经科学会议。纵向和横向指导提供各级培训和支助，以加强科学网络，并培养所有人的共同体意识听力科学学生(目前和最近的TPAN研究员，以及TPAN附属机构)，促进在博士及以后的学位。与普渡大学综合神经科学研究所合作，提供了支持，对于每个研究员的个人数据管理顾问，单独预算的与培训相关的费用，教师和学生的多元化招聘，以及行政支持。