Postdoctoral Training in Reproductive Mood Disorders

生殖情绪障碍博士后培训

基本信息

批准号：
10628811
负责人：
SUSAN S. GIRDLER
金额：
$ 24.03万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628811
关键词：
Mood Disorders post-doctoral training reproductive

项目摘要

PROJECT SUMMARY The purpose of the proposed training program, “Postdoctoral Training in Reproductive Mood Disorders” is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (peripubertal depression, perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two-to-three year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program’s emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling; methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of three methodological training tracks: Neurosciences, Genetics, or Stress Physiology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual Fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women’s mood disorder clinical program (which includes the first inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.

项目摘要拟议的培训计划“生殖情绪障碍的博士后培训”的目的是在生物学基础和临床相关（预测）表型中发展具有专业知识的研究人员生殖情绪障碍（周围抑郁症，围产期抑郁症，经前烦躁不安疾病，和绝经性抑郁症）。这是医学博士，博士和医学博士/博士学位的两到三年培训计划学员。培训将涉及一个基于广泛和综合的观点，不仅涉及精神病学，而且涉及遗传学，内分泌学，神经科学和妇产科。该计划的重点是在病理生理机制中进行培训，这些机制是复制性情绪的基础疾病，学员将在以下掌握下进行掌握：生殖激素生理和信号传导；操纵复制系统的方法；和复制情绪的临床现象学疾病。此外，学员将在至少三个方法学培训轨道中发展专业知识：神经科学，遗传学或压力生理。研究员将具有主要的研究心理（代表）他们的训练轨道）和次要心理（来自其他轨道），从而提供了额外的接触科学的跨学科性和协作性质。除了专家机会课程教师，教学学会将针对各个研究员量身定制，以确保每个成就能力他们选择的研究轨道。培训的关键要素还包括一个独立的研究项目。那虽然培训计划是多学科的，但重点是个性化培训研究员的经验。但是，通过许多特定的特定场所，旨在带来研究员共同交流思想和支持，该计划将确保学员。完成该计划的研究员将被中毒成为独立研究人员，拥有独特的必要基础，以检查复制情绪障碍中的生物行为机制能够在未来独立研究中鉴定治疗生物学靶标。北卡罗来纳大学教堂山分校代表了拟议计划的理想环境，因为它拥有众所周知的协作基础设施，这是一个充满活力的女性情绪障碍临床计划（该计划包括该国的第一个住院围产期抑郁症计划）以及大量的研究人员具有成功记录的生殖情绪障碍。

项目成果

期刊论文数量（60）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Traumatic events: exploring associations with maternal depression, infant bonding, and oxytocin in Latina mothers.

DOI：
10.1186/s12905-018-0520-5
发表时间：
2018-02-01
期刊：
BMC women's health
影响因子：
0
作者：
Lara-Cinisomo S;Zhu K;Fei K;Bu Y;Weston AP;Ravat U
通讯作者：
Ravat U

The influence of early life sexual abuse on oxytocin concentrations and premenstrual symptomatology in women with a menstrually related mood disorder.

DOI：
10.1016/j.biopsycho.2015.04.003
发表时间：
2015-07
期刊：
Biological psychology
影响因子：
2.6
作者：
Crowley SK;Pedersen CA;Leserman J;Girdler SS
通讯作者：
Girdler SS

Pretreatment brain connectivity during positive emotion upregulation predicts decreased anhedonia following behavioral activation therapy for depression.

DOI：
10.1016/j.jad.2018.09.065
发表时间：
2019-01-15
期刊：
Journal of affective disorders
影响因子：
6.6
作者：
Walsh EC;Eisenlohr-Moul TA;Minkel J;Bizzell J;Petty C;Crowther A;Carl H;Smoski MJ;Dichter GS
通讯作者：
Dichter GS

Remitted major depression is characterized by reduced prefrontal cortex reactivity to reward loss.