Postdoctoral Training in Reproductive Mood Disorders

描述（由申请人提供）：拟议的培训计划的目的，“生殖情绪障碍博士后培训”是培养具有生殖情绪障碍（围产期抑郁症，经前焦虑症和围绝经期抑郁症）的生物学基础和临床相关（预测）表型专业知识的研究人员。这是一个为期两年的MD，PhD和MD/PhD学员培训计划。培训将涉及一个基础广泛和综合的观点，不仅涉及精神病学，但心脏病学和遗传学，内分泌学，神经科学和产科/妇科。该计划强调生殖情绪障碍的病理生理机制培训，学员将掌握以下内容：生殖激素生理学和信号传导;操纵生殖系统的方法;和生殖情绪障碍的临床现象学。此外，学员将在四个方法培训轨道中的至少一个方面发展专业知识：神经科学，遗传学，压力生理学或临床试验方法学。研究员将有一个主要的研究导师（代表他们的培训轨道）和一个次要的导师（从不同的轨道），从而提供额外的接触到科学的跨学科性和协作性。除了与计划教师的经验机会，教学法将量身定制的个人研究员，以确保每个人都在他们选择的研究轨道实现能力。培训的一个关键要素还包括一个独立的研究项目。因此，虽然培训计划是多学科的，但重点是使研究员的培训经验个性化。然而，通过一些专门为方案设计的场所，使研究员们聚集在一起交流想法和提供支持，该方案将确保受训人员之间的凝聚力。完成该计划的研究员将有望成为独立的研究人员，拥有独特的必要基础来研究生殖情绪障碍的生物行为机制，并有能力在未来的独立研究中确定治疗生物靶点。位于查佩尔山的北卡罗来纳州大学为该项目提供了一个理想的环境，因为它拥有一个众所周知的合作基础设施，一个充满活力的女性情绪障碍临床项目（其中包括该国第一个住院围产期抑郁症项目），以及一批具有成功记录的生殖情绪障碍研究人员。

DESCRIPTION (provided by applicant): The purpose of the proposed training program, "Postdoctoral Training in Reproductive Mood Disorders" is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but cardiology and genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program's emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling; methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of four methodological training tracks: Neurosciences, Genetics, Stress Physiology, or Clinical Trials Methodology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women's mood disorder clinical program (which includes the first inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.