Postdoctoral Training in Reproductive Mood Disorders

描述(由申请人提供)：拟议的培训计划“生殖情绪障碍博士后培训”的目的是培养在生殖情绪障碍(围产期抑郁、经前烦躁障碍和围绝经期抑郁)的生物学基础和临床相关(预测)表型方面具有专业知识的研究人员。这是一个为期两年的培训计划，面向医学博士和医学博士/博士实习生。培训将涉及广泛和综合的观点，不仅涉及精神病学，而且涉及心脏病学和遗传学、内分泌学、神经科学和产科/妇科。本课程侧重于生殖情绪障碍的病理生理机制方面的培训，学员将掌握以下知识：生殖激素生理学和信号；控制生殖系统的方法；以及生殖情绪障碍的临床现象学。此外，受训者将至少在四个方法学培训轨道中的一个方面发展专业知识：神经科学、遗传学、压力生理学或临床试验方法论。研究员将有一名主要研究导师(代表他们的培训路线)和一名二级导师(来自不同的路线)，从而增加对科学跨学科和协作性质的接触。除了项目教员的经验机会外，教学方法将为个别研究员量身定做，以确保每个人在他们选择的研究轨道上都取得了能力。培训的一个关键要素还包括一个独立的研究项目。因此，虽然培训计划是多学科的，但重点是使研究员的培训经验个人化。然而，通过一些特定于计划的场所，旨在将研究员聚集在一起交流想法和支持，该计划将确保受训人员之间的凝聚力。完成这一计划的研究员将成为独立的研究人员，拥有独特的必要基础来检查生殖情绪障碍的生物行为机制，并有能力在未来的独立研究中确定治疗的生物靶点。北卡罗来纳大学教堂山分校是拟议项目的理想场所，因为它拥有著名的协作基础设施，充满活力的女性情绪障碍临床项目(其中包括美国第一个住院围产期抑郁症项目)，以及一大批有成功记录的生殖情绪障碍研究人员。

DESCRIPTION (provided by applicant): The purpose of the proposed training program, "Postdoctoral Training in Reproductive Mood Disorders" is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but cardiology and genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program's emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling; methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of four methodological training tracks: Neurosciences, Genetics, Stress Physiology, or Clinical Trials Methodology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women's mood disorder clinical program (which includes the first inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.