Postdoctoral Training in Reproductive Mood Disorders

描述（由申请人提供）：拟议的培训项目“生殖情绪障碍博士后培训”的目的是培养具有生殖情绪障碍（围产期抑郁症、经前焦虑症和围绝经期抑郁症）生物学基础和临床相关（预测）表型专业知识的研究人员。这是一个为期两年的医学博士、博士和医学博士/博士学员培训项目。培训将涉及广泛和综合的观点，不仅涉及精神病学，还涉及心脏病学和遗传学，内分泌学，神经科学和产科/妇科。本课程着重于生殖性情绪障碍的病理生理机制的培训，学员将掌握以下知识：生殖激素生理学和信号；操纵生殖系统的方法；以及生殖情绪障碍的临床现象学。此外，受训者将在以下四个方法学培训轨道中至少一个方面培养专业知识：神经科学、遗传学、应激生理学或临床试验方法学。研究员将有一名主要的研究导师（代表他们的培训方向）和一名次要导师（来自不同的方向），从而进一步接触科学的跨学科性和合作性质。除了与项目教师的体验机会外，教学方法将根据个人情况量身定制，以确保每个人在他们选择的研究轨道上取得能力。培训的一个关键要素还包括一个独立的研究项目。因此，虽然训练计划是多学科的，但重点是使研究员的训练经验个人化。然而，通过一些特定的项目场所，旨在将研究员聚集在一起交流想法和支持，该项目将确保学员之间的凝聚力。完成本课程的研究员将成为独立的研究人员，具有独特的必要基础来研究生殖情绪障碍的生物行为机制，并有能力在未来的独立研究中确定治疗性生物靶点。北卡罗莱纳大学教堂山分校代表了该项目的理想环境，因为它拥有知名的合作基础设施，一个充满活力的女性情绪障碍临床项目（包括国内第一个住院围产期抑郁症项目），以及一大批在生殖情绪障碍方面取得成功的研究人员。

DESCRIPTION (provided by applicant): The purpose of the proposed training program, "Postdoctoral Training in Reproductive Mood Disorders" is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but cardiology and genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program's emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling; methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of four methodological training tracks: Neurosciences, Genetics, Stress Physiology, or Clinical Trials Methodology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women's mood disorder clinical program (which includes the first inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.