Postdoctoral Training in Reproductive Mood Disorders

生殖情绪障碍博士后培训

• 批准号: 9400911
• 负责人: SUSAN S. GIRDLER
• 金额: $ 0.3万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9400911
• 关键词: Mood Disorders; post-doctoral training; reproductive

DESCRIPTION (provided by applicant): The purpose of the proposed training program, "Postdoctoral Training in Reproductive Mood Disorders" is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but cardiology and genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program's emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling; methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of four methodological training tracks: Neurosciences, Genetics, Stress Physiology, or Clinical Trials Methodology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women's mood disorder clinical program (which includes the first inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.

描述（由申请人提供）：拟议培训计划“生殖情绪障碍博士后培训”的目的是培养在生殖情绪障碍（围产期抑郁症、经前烦躁症和围绝经期抑郁症）的生物学基础和临床相关（预测）表型方面具有专业知识的研究人员。这是针对医学博士、博士和医学博士/博士学员的为期两年的培训计划。培训将涉及基础广泛和综合的视角，不仅涉及精神病学，还涉及心脏病学和遗传学、内分泌学、神经科学和妇产科。该计划强调对生殖情绪障碍的病理生理机制进行培训，学员将掌握以下内容：生殖激素生理学和信号传导；操纵生殖系统的方法；和生殖情绪障碍的临床现象学。此外，学员将至少在四个方法论培训轨道之一上发展专业知识：神经科学、遗传学、应激生理学或临床试验方法学。研究员将有一名主要研究导师（代表他们的培训方向）和一名二级导师（来自不同的方向），从而提供额外的接触科学的跨学科性和协作性质。除了与项目教师一起获得体验机会外，教学方法还将针对每位研究员量身定制，以确保每个人都能在自己选择的研究方向上取得能力。培训的一个关键要素还包括独立研究项目。因此，虽然培训计划是多学科的，但重点是为研究员提供个性化的培训体验。然而，通过一些旨在让学员聚集在一起交流想法和支持的特定项目场地，该项目将确保学员之间的凝聚力。完成该计划的研究员将成为独立研究人员，拥有检查生殖情绪障碍的生物行为机制的独特必要基础，并有能力在未来的独立研究中确定治疗生物学靶点。北卡罗来纳大学教堂山分校为拟议项目提供了理想的环境，因为它拥有众所周知的合作基础设施、充满活力的女性情绪障碍临床项目（其中包括该国第一个住院围产期抑郁症项目）以及大量在生殖情绪障碍方面取得成功的研究人员。