Postdoctoral Training in Reproductive Mood Disorders

生殖情绪障碍博士后培训

• 批准号: 9400911
• 负责人: SUSAN S. GIRDLER
• 金额: $ 0.3万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9400911
• 关键词: Mood Disorders; post-doctoral training; reproductive

DESCRIPTION (provided by applicant): The purpose of the proposed training program, "Postdoctoral Training in Reproductive Mood Disorders" is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but cardiology and genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program's emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling; methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of four methodological training tracks: Neurosciences, Genetics, Stress Physiology, or Clinical Trials Methodology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women's mood disorder clinical program (which includes the first inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.

描述（由申请人提供）：拟议的培训计划的目的是“生殖情绪障碍的博士后培训”是为了在生物学基础和临床相关（预测性的）表型中发展具有专业知识的研究人员的生殖情绪障碍表型（围产期抑郁症，前体外肾上腺疾病疾病和perimenopapausal抑郁症）。这是针对医学博士，博士和医学博士/博士学员的两年培训计划。培训将涉及基于广泛的综合视角，不仅涉及精神病学，还涉及心脏病学和遗传学，内分泌学，神经科学和妇产科。由于该计划的重点是培训生殖情绪障碍的病理生理机制，因此受训者将在以下方面掌握：生殖激素生理学和信号传导；操纵生殖系统的方法；以及生殖情绪障碍的临床现象学。此外，学员将在至少四个方法学培训轨道之一中发展专业知识：神经科学，遗传学，压力生理或临床试验方法。研究员将有一位主要的研究导师（代表他们的训练轨道）和次要导师（来自其他轨道），从而为科学的跨学科性和协作性提供了更多的曝光率。除了与课程教师的体验机会外，DoDactics还将针对各个研究员量身定制，以确保每个人都能在所选的研究轨道上实现能力。培训的关键要素还包括一个独立的研究项目。因此，尽管培训计划是多学科的，但重点是个性化研究员的培训经验。但是，通过许多旨在将研究员聚集在一起交换思想和支持的特定计划场所，该计划将确保受训者之间的凝聚力。完成该计划的研究员将有望成为独立的研究人员，拥有独特的必要基础，以检查生殖情绪障碍中的生物行为机制，以及在未来独立研究中鉴定治疗生物学目标的能力。北卡罗来纳大学教堂山分校代表了该计划的理想环境，因为它具有众所周知的协作基础设施，充满活力的女性情绪障碍临床计划（其中包括该国的第一个住院围产期抑郁症计划），以及具有成功记录的生殖情绪障碍研究人员的关键研究人员。