Postdoctoral Training in Reproductive Mood Disorders

项目总结 拟议的培训方案“生殖情绪障碍博士后培训”的目的是 培养在生物学基础和临床相关(预测)表型方面具有专长的研究人员 生殖情绪障碍(围产期抑郁、经前焦虑症和围绝经期 抑郁)。这是一个为期两年的培训计划，面向医学博士和医学博士/博士实习生。培训将包括 基础广泛和综合的观点，不仅涉及精神病学，而且涉及遗传学、内分泌学、 神经科学和妇产科。 这项计划的重点是训练生殖情绪的病理生理机制 障碍方面，学员将在以下方面发展掌握：生殖激素生理学和信号； 生殖系统的操作方法；生殖情绪的临床现象学 精神错乱。此外，受训人员将至少在以下三种方法培训中的一种中培养专门知识： 神经科学、遗传学或压力生理学。研究员将有一名主要研究导师(代表 他们的训练轨迹)和二级导师(来自不同的轨迹)，从而提供额外的接触 科学的跨学科性和协作性。除了体验机会外， 计划教员，教学方法将为个别研究员量身定做，以确保每个人在 他们选择的研究轨道。培训的一个关键要素还包括一个独立的研究项目。 因此，虽然培训计划是多学科的，但强调培训的个别化 给研究员们的经验。然而，通过一些计划特定的场馆设计，带来了 为了交换意见和支持，该计划将确保 实习生。完成这个项目的研究员将成为独立的研究人员，拥有 检查生殖情绪障碍的生物行为机制的独特必要基础和 在未来的独立研究中识别治疗生物靶点的能力。 北卡罗来纳大学教堂山分校是拟议课程的理想环境，因为它 拥有著名的协作基础设施，充满活力的女性情绪障碍临床计划(其中 包括该国第一个也是唯一一个住院围产期抑郁症计划)，以及临界质量的 在生殖情绪障碍方面有成功记录的研究人员。

PROJECT SUMMARY The purpose of the proposed training program, “Postdoctoral Training in Reproductive Mood Disorders” is to develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of reproductive mood disorders (perinatal depression, premenstrual dysphoric disorder, and perimenopausal depression). This is a two year training program for MD, PhD and MD/PhD trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but genetics, endocrinology, neuroscience, and obstetrics/gynecology. With this program’s emphasis on training in pathophysiological mechanisms that underlie reproductive mood disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling; methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood disorders. Additionally, trainees will develop expertise in at least one of thre methodological training tracks: Neurosciences, Genetics, or Stress Physiology. Fellows will have a primary research mentor (representing their training track) and a secondary mentor (from a different track), thereby providing additional exposure to both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with program faculty, didactics will be tailored to the individual fellow to ensure that each achieves competence in their chosen research track. A key element of the training as well includes an independent research project. Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training experience for the Fellows. However, through a number of program specific venues designed to bring the Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the trainees. Fellows who complete this program will be poised to become independent researchers, having the unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the ability to identify therapeutic biologic targets in their future independent research. The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it possesses a well-known collaborative infrastructure, a vibrant women’s mood disorder clinical program (which includes the first and only inpatient perinatal depression program in the country), and a critical mass of researchers in reproductive mood disorders with a track record of success.