Advanced Training in Environmental Health Sciences

项目摘要 这是一个非常成功的T32项目的竞争性续约申请，该项目已培训了200多名 在过去的45年中，毒理学/环境健康科学（EHS）的博士前学生。的目标 这个博士前计划是通过跨学科培养下一代环境卫生科学家 解决与NIEHS使命直接相关的问题的研究和课程。我们要求2 年的支持，为8名博士前学员在博士学位的第一年或第二年后开始 程序.学员是从几个加州大学戴维斯分校的研究生课程，提供纪律培训招募 与EHS相关，包括毒理学、细胞和分子生物学、暴露评估、化学、病理生物学， 流行病学、神经科学、免疫学和遗传学。培训教师-来自20个国家的35名活跃研究人员 部门-有丰富的经验指导博士前的学生。教师研究的重点是 环境因素导致人类疾病的机制，包括环境中的不同领域， EHS。通过共同参与中心和研究生院，培训教师之间的密切合作 项目以及联合资助，促进EHS研究的跨学科方法。受训人员可以访问 到先进的技术，如蛋白质组学，表观/基因组学和代谢组学，最先进的成像， 转基因生物，以及啮齿动物和非人类灵长类动物的吸入设施。EHS的优势 加州大学戴维斯分校的研究是垂直整合的研究，旨在了解环境 诱发疾病。补充人类临床样本和流行病学研究，学生有机会获得 不同的动物模型，包括非人类灵长类动物，以及实验室中的非传统模型， 对人口的实地研究。在这些模型中，学生通常开始分子，细胞和/或组织研究 在他们的教师导师的指导下，并与培训教师的投入。培训计划利用 研究中心和项目的活动和资源，以提供疾病预防之间的协同作用， 和公共卫生，同时与学生互动，在他们的科学训练的早期。培训计划 强调科学写作的实践指导和科学发现的交流，以同行和奠定 通过粉笔讲座、年度务虚会、为受邀演讲者举办的培训生小型演讲、外联活动 与社区团体合作，并参加国家会议。两个关键事件使受训者了解新兴的 环境健康的概念、争议和技术。第一个是研讨会系列， 环境卫生科学家，由受训者自己组织和管理。第二个是 暑期课程，学员在课程中探讨与环境卫生有关的当前问题， 培训师资的指导。受训人员接受培训，以负责任地进行研究，以及严谨和 透明度不仅体现在这些活动中，也体现在特别会议中。训练计划有一个很好的轨道 培训EHS领导者的记录。

PROJECT SUMMARY This is the competing renewal application for a highly successful T32 program that has trained more than 200 predoctoral students in toxicology/environmental health sciences (EHS) over the last 45 years. The objective of this predoctoral program is to train the next generation of environmental health scientists through interdisciplinary research and coursework that addresses issues of direct relevance to the NIEHS mission. We are requesting 2 years of support for each of 8 predoctoral trainees beginning after their first or second year in a PhD degree program. Trainees are recruited from several UC Davis graduate programs that provide disciplinary training relevant to EHS, including toxicology, cell and molecular biology, exposure assessment, chemistry, pathobiology, epidemiology, neuroscience, immunology, and genetics. The training faculty – 35 active researchers from 20 departments - have substantial experience mentoring predoctoral students. Faculty research focuses on mechanisms by which environmental factors contribute to human disease and encompasses diverse areas within EHS. Close collaboration among training faculty members, through joint participation in Centers and Graduate Programs as well as joint funding, promotes interdisciplinary approaches to EHS research. Trainees have access to advanced technologies, such as proteomics, epi/genomics, and metabolomics, state-of-the-art imaging, genetically modified organisms, and inhalation facilities for rodents and non-human primates. A strength of EHS research at UC Davis is the vertical integration of studies directed towards understanding environmentally induced disease. Complementing human clinical samples and epidemiologic studies, students have access to diverse animal models, including nonhuman primates, and ranging through nontraditional models in the lab to field studies of populations. In these models, students typically initiate molecular, cellular and/or tissue studies under the guidance of their faculty mentor and with input from the training faculty. The training program leverages the activities and resources of research centers and programs to provide synergy between disease prevention and public health while interacting with students early in their scientific training. The training program emphasizes practical instruction in scientific writing and communication of scientific findings to peers and lay audiences through chalk talks, annual retreats, trainee mini presentations for invited speakers, outreach activities with community groups, and participation in national meetings. Two key events expose trainees to emerging concepts, controversies, and technologies in environmental health. The first is a seminar series featuring leading environmental health scientists that is organized and managed by the trainees themselves. The second is a summer course in which trainees explore a current issue relevant to environmental health under the close guidance of training faculty. Trainees receive training in responsible conduct of research as well as rigor and transparency woven into these events but also in special sessions. The training program has an excellent track record of training leaders in EHS.