LISTOS for Cancer Control - Leveraging Implementation Science To Optimize Strategies for Cancer Control

摘要 墨西哥和拉丁美洲的人口经历了大量与癌症相关的健康 与高收入国家相比，这是不平等的。循证癌症执行不力 控制干预(EBI)在一定程度上要对此负责。我们建议建立一个新的中心：杠杆 实施科学优化策略(LISTOS)推进癌症控制 全球实施科学(IS)在墨西哥和拉丁美洲的癌症控制。通过两个 针对关键癌症控制需求的研究研究，以及两个核心(管理和研究 能力建设)，LISTOS中心将：1)为实施 墨西哥癌症控制EBIS；和2)通过能力建设为实施研究做好准备 建设、培训和指导。LISTOS中心有两个与内容相关的子主题 与控制癌症的EBI可以被“优化”的两种主要方式相对应：1)适应EBI 实施战略，以更好地适应墨西哥不同的人口和环境；以及 2)制定实施战略，以改善和加快EBI的采用、整合、扩大、 以及在墨西哥的维持性。这些子主题被整合到研究项目和核心中。 行政和参与核心将提供领导；提供行政 支持、协调、沟通和参与活动；并领导传播工作。 利用丰富的IS培训经验、现有计划以及强大而多样化的 调查人员、导师和合作伙伴，研究能力建设核心将支持一系列 在整个拉丁美洲培训下一代IS领导人的活动。LISTOS中心核心 将支持两项创新研究，这两项研究将增加覆盖范围、有效性和 在为弱势人群提供服务的卫生保健系统中维持癌症早期发现 墨西哥，使用创新和可扩展的实施战略。这些研究的目的是：1)增加 在公共保险保健系统中采用、实施和维持CRCS EBIs；以及 2)将乳腺癌快速诊断路径整合到为未参保人群提供的医疗服务中。 该中心利用创新和量身定做的方法，使基于LMIC的新一代 研究人员将进行研究，以加速和改进有效和可扩展癌症的使用 控制EBIS。这两个目标都将促进LMIC(测量， 适应和战略制定)，并创造一个可持续的基础设施，使 在未来几年继续为这一领域做出贡献。

ABSTRACT Populations in Mexico and Latin America experience substantial cancer-related health inequities compared to those in high-income countries. Poor implementation of evidence-based cancer control interventions (EBIs) is, in part, to blame. We propose to establish a new Center: Leveraging Implementation Science To Optimize Strategies (LISTOS) for Cancer Control to advance global implementation science (IS) in cancer control in Mexico and Latin America. Through two research studies that address critical cancer control needs, and two cores (Administrative, and Research Capacity Building), the LISTOS Center will: 1) build organizational readiness for implementation of cancer control EBIs in Mexico; and 2) build readiness for implementation research through capacity building, training, and mentorship. The LISTOS Center has two content-related subthemes corresponding to the two primary ways that cancer control EBIs can be “optimized”: 1) adapting EBIs and implementation strategies to improve fit with the diverse populations and settings in Mexico; and 2) developing implementation strategies to improve and accelerate EBI adoption, integration, scale-up, and sustainment in Mexico. These subthemes are integrated across the research projects and cores. The Administrative and Engagement Core will provide leadership; offer administrative support, coordination, communication, and engagement activities; and lead dissemination efforts. Leveraging substantial IS training experience, existing programs, and a strong and diverse team of investigators, mentors, and partners, the Research Capacity Building Core will support a range of activities to train the next generation of IS leaders throughout Latin America. The LISTOS center cores will support two innovative research studies that will increase the reach, effectiveness, and sustainment of cancer early detection in health care systems that serve disadvantaged populations in Mexico, using innovative and scalable implementation strategies. These studies aim to: 1) increase the adoption, implementation, and sustainment of CRCS EBIs in a public insurance healthcare system; and 2) integrate breast cancer rapid diagnosis pathways across health services available for the uninsured. The Center utilizes innovative and tailored approaches that will enable a new generation of LMIC-based researchers to conduct research that will accelerate and improve the use of effective and scalable cancer control EBIs. The aims will both advance the science of implementation in LMICs (measurement, adaptation, and strategy development) and create a sustainable infrastructure that will enable continued contributions to the field for years to come.