LISTOS for Cancer Control - Leveraging Implementation Science To Optimize Strategies for Cancer Control

LISTOS 用于癌症控制 - 利用实施科学来优化癌症控制策略

• 批准号: 10738709
• 负责人: Maria Eulalia Fernandez
• 金额: $ 99.73万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10738709
• 关键词: Acceleration; Address; Adoption; Cancer Burden; Cancer Control; Collaborations; Communication; Consolidated Framework for Implementation Research; Country; Development; Diagnosis; Disparity population; Dissemination and Implementation; Effectiveness; Ensure; Equity; Evidence based intervention; Funding; Generations; Goals; Health Services Accessibility; Health system; Healthcare Systems; Implementation readiness; Income; Infrastructure; Institution; Interactive Systems Framework; Intervention; Language; Latin America; Latin American; Lead; Leadership; Learning; Malignant Neoplasms; Maps; Measurement; Measures; Mentors; Mentorship; Methodology; Methods; Mexico; Modeling; Motivation; National Cancer Institute; Pathway interactions; Persons; Population; Population Heterogeneity; Primary Care; Problem-Based Learning; Public Health; Readiness; Research; Research Personnel; Research Project Grants; Research Support; Resources; Science; Scientist; Screening for cancer; System; Testing; Training; Training Activity; Uninsured; Work; base; breast cancer diagnosis; career; colorectal cancer screening; design; evidence base; experience; follow-up; health inequalities; implementation research; implementation science; implementation strategy; improved; innovation; integrated care; low and middle-income countries; malignant breast neoplasm; next generation; organizational readiness; personalized approach; programs; public health insurance; rapid diagnosis; research study; scale up; theories; tool; uptake

ABSTRACT Populations in Mexico and Latin America experience substantial cancer-related health inequities compared to those in high-income countries. Poor implementation of evidence-based cancer control interventions (EBIs) is, in part, to blame. We propose to establish a new Center: Leveraging Implementation Science To Optimize Strategies (LISTOS) for Cancer Control to advance global implementation science (IS) in cancer control in Mexico and Latin America. Through two research studies that address critical cancer control needs, and two cores (Administrative, and Research Capacity Building), the LISTOS Center will: 1) build organizational readiness for implementation of cancer control EBIs in Mexico; and 2) build readiness for implementation research through capacity building, training, and mentorship. The LISTOS Center has two content-related subthemes corresponding to the two primary ways that cancer control EBIs can be “optimized”: 1) adapting EBIs and implementation strategies to improve fit with the diverse populations and settings in Mexico; and 2) developing implementation strategies to improve and accelerate EBI adoption, integration, scale-up, and sustainment in Mexico. These subthemes are integrated across the research projects and cores. The Administrative and Engagement Core will provide leadership; offer administrative support, coordination, communication, and engagement activities; and lead dissemination efforts. Leveraging substantial IS training experience, existing programs, and a strong and diverse team of investigators, mentors, and partners, the Research Capacity Building Core will support a range of activities to train the next generation of IS leaders throughout Latin America. The LISTOS center cores will support two innovative research studies that will increase the reach, effectiveness, and sustainment of cancer early detection in health care systems that serve disadvantaged populations in Mexico, using innovative and scalable implementation strategies. These studies aim to: 1) increase the adoption, implementation, and sustainment of CRCS EBIs in a public insurance healthcare system; and 2) integrate breast cancer rapid diagnosis pathways across health services available for the uninsured. The Center utilizes innovative and tailored approaches that will enable a new generation of LMIC-based researchers to conduct research that will accelerate and improve the use of effective and scalable cancer control EBIs. The aims will both advance the science of implementation in LMICs (measurement, adaptation, and strategy development) and create a sustainable infrastructure that will enable continued contributions to the field for years to come.

抽象的 墨西哥和拉丁美洲的人口患有大量与癌症相关的健康问题 与高收入国家相比存在不平等。循证癌症实施不力 控制干预（EBI）是部分原因。我们建议建立一个新的中心：利用 实施科学优化策略（LISTOS）以推进癌症控制 墨西哥和拉丁美洲癌症控制的全球实施科学（IS）。通过两个 解决关键癌症控制需求的研究和两个核心（管理和研究） 能力建设），LISTOS 中心将：1）为实施 墨西哥的癌症控制 EBI； 2）通过能力为实施研究做好准备 建设、培训和指导。 LISTOS 中心有两个与内容相关的子主题 对应于癌症控制 EBI 可以“优化”的两种主要方式：1）调整 EBI 改善与墨西哥不同人群和环境的契合度的实施战略；和 2) 制定实施策略，以改进和加速 EBI 采用、整合、扩大规模， 和墨西哥的维持。这些子主题被整合到研究项目和核心中。 行政和参与核心将提供领导；提供行政管理 支持、协调、沟通和参与活动；并领导传播工作。 利用丰富的信息系统培训经验、现有计划以及强大而多元化的团队 研究能力建设核心将支持一系列研究人员、导师和合作伙伴 培训整个拉丁美洲下一代伊斯兰国领导人的活动。 LISTOS 中心核心 将支持两项创新研究，以扩大影响范围、有效性和 在为弱势群体提供服务的医疗保健系统中维持癌症早期检测 墨西哥，采用创新且可扩展的实施战略。这些研究的目的是：1）增加 在公共保险医疗保健系统中采用、实施和维持 CRCS EBI；和 2) 将乳腺癌快速诊断途径整合到为未参保者提供的医疗服务中。 该中心采用创新和量身定制的方法，使新一代的中低收入国家成为可能 研究人员进行的研究将加速和改善有效且可扩展的癌症的使用 控制 EBI。这些目标都将促进中低收入国家的实施科学（测量、 适应和战略制定）并创建可持续的基础设施，使 未来几年继续对该领域做出贡献。