Ecological Assessment of Cognitive Control in Individuals with Social Anxiety
社交焦虑个体认知控制的生态评估
基本信息
- 批准号:10740262
- 负责人:
- 金额:$ 40.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:17 year oldAdolescenceAdolescentAffectAgeAnxietyBehaviorBehavioralBrainCharacteristicsChildhoodComputersDataData CollectionDetectionDiseaseElectroencephalographyEmotionsExhibitsFutureGoalsHypersensitivityImpairmentIndividualInterventionInterviewInvestigational TherapiesK-12 EducationLaboratoriesLettersLinkMeasuresMental disordersMethodsMissionModelingMonitorNatural ExtractParticipantPerceptionPilot ProjectsPopulationProbabilityProcessProtocols documentationQualitative MethodsQuality of lifeReadingResponse to stimulus physiologyRoleSamplingSelf AssessmentSeriesSocial Anxiety DisorderSpeedStimulusStressStructureSystemTask PerformancesTherapeuticTranscriptValidationWorkYouthanxiety statesbehavior measurementbehavioral responsebrain basedcognitive controlcognitive neurosciencedemographicsdesignhigh riskneuralneuromechanismnovelpeerresponsesocialsocial anxietysocial observationsstandardize measuresuccesstherapeutic targettrait
项目摘要
PROJECT SUMMARY
Social anxiety disorder is an impairing condition that typically emerges during adolescence, affecting about 10%
of the population. Models of social anxiety (SA) elucidate excessive self-focus and sensitivity to mistakes as
factors that negatively impact quality of life. Using traditional cognitive neuroscience paradigms, prior work has
identified neural measures associated with enhanced self-detection of errors (Error Monitoring), that predicts SA,
as well as anxiety more generally. However, a major challenge with translational interventions developed from
cognitive neuroscience paradigms is the transfer to ecologically valid settings. There is a critical need for the
design and validation of novel tasks/protocols to identify and reliably measure brain-based therapeutic targets
for SA within ecologically valid, “real-world” settings that are applicable to youth. In line with our long-term goal
of developing brain-based interventions for adolescent SA, the purpose of this proposal is to optimize and
validate a novel, ecologically-valid task that will reliably assess neural and behavioral measures associated with
social anxiety. We propose a sequential, multi-study project that leverages a mixed-methods approach to
optimize and validate our novel Natural Reading task and demonstrate its utility in predicting SA. By developing
an ecologically-valid paradigm early in the experimental therapeutics process, we increase the probability of
successful transfer of effects in future interventions that target measures captured by this novel task; in this way,
our proposal is strongly aligned with the Institute’s mission to transform the understanding and treatment of
mental illnesses. We propose two aims: (1) a pilot study to optimize the design of our novel Natural Reading task
and (2) a second study to establish the reliability and predictive power of the Natural Reading task in relation to
SA. In Study 1, 10 youths (13-17 yrs., 5 high and 5 low SA) will perform the Natural Reading task and a traditional
Flanker task, both alone and while under social observation by a peer. To investigate experiential aspects of
task completion, including participants' perceptions and self-assessed task performance, qualitative methods will
be employed in the analysis of semi-structured interview data. Qualitative results will be leveraged to optimize
design of the Natural Reading task prior to proceeding with Study 2 data collection (Aim 2). For Study 2, within
a second sample of 80 youth (13-17 yrs.), participants will perform an optimized version of the Natural Reading
task and a traditional Flanker task, alone and under peer observation. Neural measures of Error Monitoring,
along with associated behavioral measures, will be extracted to perform quantitative analyses. Hypothesis 2A:
Both tasks will exhibit acceptable levels of reliability in neural and behavioral measures. Hypothesis 2B: Within
each task, measures of Error Monitoring extracted from the peer (vs. alone) condition will predict additional
variance in trait SA and state anxiety levels. Hypothesis 2C: Focusing on the peer condition, measures of Error
Monitoring extracted from the Natural Reading Task will predict additional variance in SA, above and beyond
measures of Error Monitoring extracted from the traditional Flanker task.
项目总结
社交焦虑症是一种损害健康的疾病,通常出现在青春期,影响约10%
人口中的一部分。社交焦虑(SA)模型将过度自我关注和对错误的敏感性解释为
负面影响生活质量的因素。使用传统的认知神经科学范式,以前的工作已经
识别与增强的错误自我检测(错误监控)相关联的神经测量,预测SA,
以及更普遍的焦虑。然而,翻译干预的一个主要挑战是从
认知神经科学范式是向生态有效环境的转移。目前迫切需要的是
识别和可靠测量基于脑的治疗靶点的新任务/方案的设计和验证
对于在生态上有效的、适用于青年的“现实世界”环境中的SA。符合我们的长期目标
为青少年SA开发基于大脑的干预措施,该提案的目的是优化和
验证一项新颖的、生态有效的任务,该任务将可靠地评估与
社交焦虑症。我们提出了一个顺序的、多项研究的项目,该项目利用混合方法来
优化和验证我们的新自然阅读任务,并展示其在预测SA方面的有效性。通过开发
一个生态有效的范例,在实验治疗过程的早期,我们增加了
在针对这项新任务所捕捉的措施的未来干预措施中成功地转移效果;以这种方式,
我们的建议与研究所的使命非常一致,即改变对
精神疾病。我们提出了两个目标:(1)一项优化小说自然阅读任务设计的初步研究
以及(2)建立自然阅读任务的可靠性和预测力的第二研究
莎拉。在研究1中,10名青少年(13-17岁,5个高SA和5个低SA)将执行自然阅读任务和传统的
侧翼任务,无论是单独的还是在同伴的社会观察下。研究体验方面的问题
任务完成,包括参与者的感知和自我评估的任务绩效,定性方法将
被用来分析半结构化访谈数据。将利用定性结果来优化
在进行研究2的数据收集之前设计自然阅读任务(目标2)。对于研究2,在
第二个样本是80名青少年(13-17岁),参与者将执行自然阅读的优化版本
任务和传统的侧翼任务,单独和在同行观察下。误差监测的神经措施,
以及相关的行为测量,将被提取以执行定量分析。假设2A:
这两项任务都将在神经和行为测量中显示出可接受的可靠性水平。假设2B:内部
每项任务、从同级(与单独)条件中提取的错误监控措施将预测其他
特质焦虑和状态焦虑水平的差异。假设2C:关注同伴的状况,错误的衡量标准
从自然阅读任务中提取的监测将预测SA的额外差异,超过或超过
从传统侧翼任务中提取的错误监测措施。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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专利数量(0)
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{{ truncateString('George Arthur Buzzell', 18)}}的其他基金
A developmentally-sensitive mechanism underlying the escalation of adolescent social anxiety
青少年社交焦虑升级的发育敏感机制
- 批准号:
10707188 - 财政年份:2022
- 资助金额:
$ 40.56万 - 项目类别:
A developmentally-sensitive mechanism underlying the escalation of adolescent social anxiety
青少年社交焦虑升级的发育敏感机制
- 批准号:
10566856 - 财政年份:2022
- 资助金额:
$ 40.56万 - 项目类别:
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