Ecological Assessment of Cognitive Control in Individuals with Social Anxiety

社交焦虑个体认知控制的生态评估

• 批准号: 10740262
• 负责人: George Arthur Buzzell
• 金额: $ 40.56万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740262
• 关键词: 17 year old; Adolescence; Adolescent; Affect; Age; Anxiety; Behavior; Behavioral; Brain; Characteristics; Childhood; Computers; Data; Data Collection; Detection; Disease; Electroencephalography; Emotions; Exhibits; Future; Goals; Hypersensitivity; Impairment; Individual; Intervention; Interview; Investigational Therapies; K-12 Education; Laboratories; Letters; Link; Measures; Mental disorders; Methods; Mission; Modeling; Monitor; Natural Extract; Participant; Perception; Pilot Projects; Population; Probability; Process; Protocols documentation; Qualitative Methods; Quality of life; Reading; Response to stimulus physiology; Role; Sampling; Self Assessment; Series; Social Anxiety Disorder; Speed; Stimulus; Stress; Structure; System; Task Performances; Therapeutic; Transcript; Validation; Work; Youth; anxiety states; behavior measurement; behavioral response; brain based; cognitive control; cognitive neuroscience; demographics; design; high risk; neural; neuromechanism; novel; peer; response; social; social anxiety; social observations; standardize measure; success; therapeutic target; trait

PROJECT SUMMARY Social anxiety disorder is an impairing condition that typically emerges during adolescence, affecting about 10% of the population. Models of social anxiety (SA) elucidate excessive self-focus and sensitivity to mistakes as factors that negatively impact quality of life. Using traditional cognitive neuroscience paradigms, prior work has identified neural measures associated with enhanced self-detection of errors (Error Monitoring), that predicts SA, as well as anxiety more generally. However, a major challenge with translational interventions developed from cognitive neuroscience paradigms is the transfer to ecologically valid settings. There is a critical need for the design and validation of novel tasks/protocols to identify and reliably measure brain-based therapeutic targets for SA within ecologically valid, “real-world” settings that are applicable to youth. In line with our long-term goal of developing brain-based interventions for adolescent SA, the purpose of this proposal is to optimize and validate a novel, ecologically-valid task that will reliably assess neural and behavioral measures associated with social anxiety. We propose a sequential, multi-study project that leverages a mixed-methods approach to optimize and validate our novel Natural Reading task and demonstrate its utility in predicting SA. By developing an ecologically-valid paradigm early in the experimental therapeutics process, we increase the probability of successful transfer of effects in future interventions that target measures captured by this novel task; in this way, our proposal is strongly aligned with the Institute’s mission to transform the understanding and treatment of mental illnesses. We propose two aims: (1) a pilot study to optimize the design of our novel Natural Reading task and (2) a second study to establish the reliability and predictive power of the Natural Reading task in relation to SA. In Study 1, 10 youths (13-17 yrs., 5 high and 5 low SA) will perform the Natural Reading task and a traditional Flanker task, both alone and while under social observation by a peer. To investigate experiential aspects of task completion, including participants' perceptions and self-assessed task performance, qualitative methods will be employed in the analysis of semi-structured interview data. Qualitative results will be leveraged to optimize design of the Natural Reading task prior to proceeding with Study 2 data collection (Aim 2). For Study 2, within a second sample of 80 youth (13-17 yrs.), participants will perform an optimized version of the Natural Reading task and a traditional Flanker task, alone and under peer observation. Neural measures of Error Monitoring, along with associated behavioral measures, will be extracted to perform quantitative analyses. Hypothesis 2A: Both tasks will exhibit acceptable levels of reliability in neural and behavioral measures. Hypothesis 2B: Within each task, measures of Error Monitoring extracted from the peer (vs. alone) condition will predict additional variance in trait SA and state anxiety levels. Hypothesis 2C: Focusing on the peer condition, measures of Error Monitoring extracted from the Natural Reading Task will predict additional variance in SA, above and beyond measures of Error Monitoring extracted from the traditional Flanker task.

项目摘要 社交焦虑症是一种损害性疾病，通常出现在青春期，影响约10% 的人口。社交焦虑（SA）模型阐明了过度的自我关注和对错误的敏感性， 影响生活质量的因素。使用传统的认知神经科学范式，先前的工作 识别与增强的自我错误检测（错误监测）相关的神经测量，预测SA， 以及更普遍的焦虑。然而，翻译干预的一个主要挑战是， 认知神经科学范式是向生态有效环境的转移。目前迫切需要 设计和验证新的任务/方案，以识别和可靠地测量基于大脑的治疗靶点 对于SA来说，在适用于青少年的生态有效的“现实世界”环境中。符合我们的长期目标 为青少年SA开发基于大脑的干预措施，这项建议的目的是优化和 验证一个新的，生态有效的任务，将可靠地评估神经和行为的措施， 社交焦虑我们提出了一个顺序的，多研究项目，利用混合方法的方法， 优化和验证我们的新自然阅读任务，并证明其在预测SA的效用。发展中 在实验治疗过程的早期，我们增加了 在未来的干预措施中成功地转移效果，这些干预措施针对这项新任务所捕获的措施;这样， 我们的建议与研究所的使命是一致的，即改变对 精神疾病我们提出了两个目标：（1）优化自然阅读任务设计的初步研究 （2）第二项研究，以建立自然阅读任务的可靠性和预测能力， SA.在研究1中，10名青少年（13-17岁，5高和5低SA）将执行自然阅读任务和传统的 侧卫任务，包括单独和在同伴的社会观察下。为了研究 任务完成，包括参与者的看法和自我评估的任务表现，定性方法将 用于半结构化访谈数据的分析。将利用定性结果来优化 在进行研究2数据收集之前设计自然阅读任务（目标2）。对于研究2，在 第二个样本为80名青年（13-17岁），参与者将执行自然阅读的优化版本 任务和传统的侧卫任务，单独和同伴观察。错误监控的神经措施， 沿着提取相关的行为指标以进行定量分析。假设2A： 这两项任务在神经和行为测量方面都将表现出可接受的可靠性水平。假设2B：内部 每项任务，从对等（与单独）条件中提取的错误监控措施将预测额外的 特质SA和状态焦虑水平的差异。假设2C：关注同伴条件，错误的测量 从自然阅读任务中提取的监测将预测SA的额外变化，超过或超过 从传统的侧卫任务中提取的错误监控措施。