The ECHO Minnesota Asian American and Pacific Islander Pre-Conception and Pregnancy Cohort

ECHO 明尼苏达州亚裔美国人和太平洋岛民受孕前和怀孕队列

• 批准号: 10745884
• 负责人: HONG-NGOC B. NGUYEN
• 金额: $ 165.34万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745884
• 关键词: Advocate; Area; Asian; Asian Americans; Asian population; Attitude; Belief; Birth; Body Composition; Body mass index; Cardiometabolic Disease; Chemical Exposure; Chemicals; Child; Clinical Research; Cohort Analysis; Collaborations; Collection; Communities; Conceptions; Couples; Data; Data Element; Enrollment; Environment; Environmental Health; Ethnic Origin; Ethnic Population; Failure; Family; Fetal Development; Health; Health Professional; Healthcare; Healthcare Systems; Individual; Infant; Infant Development; Institution; Intervention; Knowledge; Life Style; Literature; Measures; Medical; Medical Research; Methodology; Minnesota; Minority; Minority Groups; Modeling; Modification; National Health and Nutrition Examination Survey; Obesity; Outcome; Pacific Islander; Participant; Pediatric cohort; Performance; Persons; Pregnancy; Prenatal care; Publishing; Race; Recommendation; Reporting; Research; Research Personnel; Risk; Role; Stigmatization; Subgroup; Transcend; Underrepresented Populations; Universities; Urine; Visit; Weight; Woman; aged; anti-Asian; cancer survival; clinical epidemiology; cohort; environmental health disparity; health data; improved; indexing; metropolitan; middle childhood; multi-ethnic; novel; phthalates; pregnant; programs; racial difference; racial population; recruit; reproductive; sexual dimorphism; southeast Asian; success

ABSTRACT The Asian population in the U.S. has nearly doubled since the year 2000. Overall, 6.5% of births in the U.S. are to Asian people, yet a recently published ECHO Cohort analysis of pregnancies indicated that only 5.0% of the nearly 22,000 pregnancies included were to Asian people, representing just over 1,000 pregnant Asians. Despite efforts to be inclusive at enrollment across individual cohorts, the ECHO Cohort may include too few pregnant people of this underrepresented minority group to allow for meaningful examination of important race-related associations. Concerns about insufficient statistical power are heightened when analyses require disaggregation of data by Asian ethnicity due to heterogeneous risks. This proposal aims to increase the power and significance of the ECHO Cohort by enrolling an additional 780 pregnant Asian people representing multiple Asian ethnic groups from the three largest healthcare systems in the Minneapolis/St. Paul metropolitan area, along with their conceiving partners and the index infant. Our institutional expertise supports our focus on physical & chemical and lifestyle measures for our Specialized Exposures, and obesity as our Specialized Outcome. This study will allow us to further examine environmental health disparities among Asians, particularly among Southeast Asians such at the Hmong, who overwhelmingly represent the largest Asian ethnicity in Minnesota. For example, reproductive-aged Hmong women have been found to have significantly higher levels of certain phthalate metabolites compared to NHANES averages; given the documented effects of phthalates on fetal development, this is particularly concerning because Hmong women are roughly twice as likely to have had a birth in the last year compared to all other women. Our scientific aims will investigate the role of phthalates on sexually dimorphic outcomes including body composition in Asian ECHO Cohort participants. Our operational aim will use the exceptional performance of our research team during the first seven years of the ECHO Cohort to enroll multi- ethnic Asian participants. We will employ a novel recruitment methodology that transcends healthcare systems and that will identify a pregnant person at their first prenatal visit, then allowing research professionals from their own healthcare institution to recruit for our cohort. Upon enrollment, our study team will coordinate effortless biospecimen collection from their routine prenatal visits (and during delivery), while providing in-person (remote when necessary) study visits at our conveniently located Epidemiology Clinical Research Center; we will retain our Asian families using community-engaged approaches. Children resulting from the pregnancy, and the conceiving partner, will also be enrolled. 117 (15%) of these once-pregnant Asian people who may become pregnant again, along with their conceiving partners, will be re-enrolled into the ECHO Pre-Conception Pilot. This unprecedented collaboration of healthcare systems will leverage our previous successes within the ECHO Cohort and provide valuable environmental health data to improve the health of Asian American communities.

摘要 自2000年以来，美国的亚裔人口几乎翻了一番。总体而言，美国6.5%的新生儿是 然而，最近发表的ECHO队列怀孕分析表明，只有5.0%的亚洲人， 其中近22，000例怀孕是亚洲人，代表了1，000多名怀孕的亚洲人。尽管 为了努力在入组时纳入各个队列，ECHO队列可能纳入太少的妊娠 这一代表性不足的少数群体的人，以允许有意义的审查重要的种族有关的 协会.当分析需要分列时，对统计功效不足的关切就更加突出 由于风险的异质性，亚洲种族的数据。这项建议旨在增加权力和意义， ECHO队列再招募780名代表多个亚洲种族的怀孕亚洲人 来自明尼阿波利斯/圣保罗大都市区三大医疗保健系统的团体，沿着 怀孕的伴侣和第一个婴儿。我们的机构专业知识支持我们专注于物理和化学 和生活方式的措施，我们的专业暴露，和肥胖作为我们的专业成果。本研究将 让我们进一步研究亚洲人，特别是东南亚人之间的环境健康差异， 比如苗族，他们是明尼苏达州最大的亚裔族群。比如说， 生育年龄的苗族妇女已被发现有显着较高的水平，某些邻苯二甲酸酯 代谢物与NHANES平均值相比;考虑到邻苯二甲酸酯对胎儿发育的影响， 这是特别令人担忧的，因为苗族妇女在过去一年中生育的可能性大约是过去的两倍。 与其他所有女性相比。我们的科学目标是研究邻苯二甲酸酯对性二形性的作用。 结果包括亚洲ECHO队列受试者的身体组成。我们的行动目标是利用 我们的研究团队在ECHO队列研究的前七年中表现出色， 亚裔参与者。我们将采用一种超越医疗保健系统的新型招聘方法 这将在第一次产前检查时识别出怀孕的人，然后允许研究专业人员从他们的 为我们的队列招募自己的医疗机构。一旦入组，我们的研究团队将毫不费力地协调 从常规产前访视（和分娩期间）采集生物样本，同时亲自（远程） 必要时）在我们便利的流行病学临床研究中心进行研究访视;我们将保留 我们的亚洲家庭使用社区参与的方法。怀孕所生子女，以及 怀孕的伴侣，也将被录取。117（15%）这些曾经怀孕的亚洲人谁可能成为 再次怀孕的女性，沿着其怀孕伴侣，将重新入组ECHO孕前试验。 这种前所未有的医疗保健系统合作将利用我们以前在ECHO内的成功 队列和提供有价值的环境健康数据，以改善亚裔美国人社区的健康。