ECHO in Agricultural Washington and Rural Environments (ECHO AWARE)

华盛顿农业和农村环境中的 ECHO (ECHO AWARE)

• 批准号: 10745817
• 负责人: CATHERINE J KARR
• 金额: $ 87.62万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745817
• 关键词: Acceleration; Address; Adverse effects; Affect; Age; Agriculture; Air; Air Pollutants; Air Pollution; Animal Model; Award; Awareness; Behavior; Birth; Chemical Exposure; Chemicals; Child; Child Health; Childhood; Clinic; Collection; Communication Tools; Communities; Community Health Services; Conceptions; Consultations; Cultural Backgrounds; Data; Data Collection; Development; Discipline; Disparity; Documentation; Dose; Economics; Effectiveness; Enrollment; Environmental Epidemiology; Environmental Exposure; Event; Exposure disparity; Exposure to; Face; Faculty; Family; Federally Qualified Health Center; Fertility; Fostering; Health; Health Promotion; Home; Individual; Institution; Investigation; Knowledge; Latino; Latino Population; Lead; Leadership; Life; Manuscripts; Medical; Methods; Modeling; Mothers; Natural experiment; Outcome; Paper; Participant; Pesticides; Phase; Policies; Poly-fluoroalkyl substances; Population; Positioning Attribute; Pregnancy; Productivity; Protocols documentation; Public Health; Research; Research Activity; Research Design; Research Personnel; Resources; Risk; Risk Factors; Role; Rural; Rural Community; Rural Health; Rural Minority; Science; Scientist; Series; Site; Smoke; Students; Translations; Uncertainty; Universities; Washington; Wildfire; Yakama Indian; Yakima Valley; access disparities; agricultural community; biobank; built environment; burden of illness; career; career development; climate change; cohort; community based participatory research; community engaged research; community engagement; design; drinking water; early life exposure; effectiveness evaluation; environmental justice; epidemiologic data; experience; experimental analysis; farm worker; fine particles; hazard; health disparity; improved; indexing; insight; minority communities; modifiable risk; multidisciplinary; novel; peer; pollutant; pregnant; prenatal; programs; recruit; resilience factor; respiratory health; response; rural America; rural environment; sample collection; sociodemographics; spatiotemporal; success; tool; ultrafine particle; undergraduate student; well water

ABSTRACT ECHO AWARE (ECHO in Agricultural Washington and Rural Environments) enriches the ECHO Program in two primary ways. 1) We will increase representation of rural and agricultural communities, particularly Latino families, in the ECHO Cohort. Rural children experience many health and environmental exposure disparities, yet are poorly represented in research and in the current ECHO Cohort. With deep community-engaged research ties to Washington’s agricultural Yakima Valley, our team is poised to enroll over 1000 pregnant individuals through partnership with their medical home and Federally Qualified Health Center (Yakima Valley Farm Workers Clinic). We also partner with Heritage University to involve Latino and Yakama Nation undergraduates and junior faculty to exchange perspectives regarding ECHO research practice and foster biomedical career development in this environmental justice community. Biospecimen collection will be led by a subteam with experience directing a biorepository for >10,000 pregnancies. 2) Our investigator team (diverse in career stage, scientific discipline, institution, cultural background) advances ECHO collaborative science in air pollution, airway health, and rural health. We propose a new cross-cohort Rural Health Workgroup plus a series of ECHO manuscripts to understand the health conditions and risk factors for under-resourced and minoritized communities in rural America, as well as best practices for engaging these hard-to-reach populations. A set of novel preconception analyses addresses widespread contaminants of concern for drinking water wells, an underdeveloped topic for ECHO. We also leverage decades of air pollution expertise to expand the air pollution exposures available for ECHO analyses and conduct solution-oriented research to directly inform U.S. regulatory policy and public health promotion programs. Our team contributes expertise in advanced methods for air pollution, including those for exposure mixtures. We also bring new national models for outdoor air pollutants of emerging concern to ECHO, including wildfire smoke (WFS) and ultrafine particulate matter (UFP). We first develop an improved national model for WFS to enable much-needed research on this climate-change driven catastrophe and lead manuscripts to describe impacts on US children. We then develop a new national model of UFP, an unregulated pollutant demonstrating high toxic potential in animal models yet with little epidemiological data. We also propose brief, low-burden extensions to the ECHO Protocol to better characterize rural chemical exposures as well as knowledge of the Air Quality Index (AQI) to explore disparities in access to this public health tool and evaluate its effectiveness in mitigating health effects. A proposed Wildfire Rapid Response Protocol will support natural experiment analyses of wildfire related health crises. Overall, ECHO AWARE builds on prior successes and insights gained as the ECHO PATHWAYS multi-cohort award center point for project coordination and team science; we continue these efforts in ECHO 2.0 with a focus on solution-oriented research, community-engagement, and translation.

抽象的 ECHO AWARE（华盛顿农业和农村环境中的 ECHO）丰富了 ECHO 计划 两种主要方式。 1）我们将增加农村和农业社区的代表性，特别是拉丁裔 家庭，在 ECHO 队列中。农村儿童在健康和环境暴露方面存在许多差异， 但在研究和当前的 ECHO 队列中代表性不足。深入社区参与 与华盛顿州农业亚基马谷的研究联系，我们的团队准备招募 1000 多名孕妇 通过与其医疗之家和联邦合格健康中心（亚基马谷）合作的个人 农场工人诊所）。我们还与传统大学合作，让拉丁裔和亚卡马民族参与其中 本科生和初级教师交流有关 ECHO 研究实践的观点并培养 这个环境正义社区的生物医学职业发展。生物样本收集将由 一个拥有指导超过 10,000 例妊娠的生物样本库经验的子团队。 2）我们的调查员团队（多元化 在职业阶段、科学学科、机构、文化背景）推进 ECHO 协作科学 空气污染、气道健康和农村健康。我们提议成立一个新的跨群体农村卫生工作组以及 系列 ECHO 手稿，旨在了解资源贫乏和贫困人群的健康状况和风险因素 美国农村的少数族裔社区，以及吸引这些难以接触到的群体的最佳实践 人口。一组新颖的先入之见分析解决了人们关注的广泛污染物 饮用水井，这是 ECHO 尚未开发的主题。我们还利用数十年的空气污染专业知识 扩大可用于 ECHO 分析的空气污染暴露范围，并进行以解决方案为导向的研究 直接告知美国监管政策和公共卫生促进计划。我们的团队贡献专业知识 空气污染的先进方法，包括暴露混合物的方法。我们还带来了新的国模 针对 ECHO 新兴关注的室外空气污染物，包括野火烟雾 (WFS) 和超细烟雾 颗粒物（UFP）。我们首先开发一个改进的世界粮食安全国家模型，以实现急需的 对这场气候变化引发的灾难进行研究，并撰写手稿来描述对美国儿童的影响。 然后，我们开发了一种新的 UFP 国家模型，这是一种不受管制的污染物，在 动物模型但流行病学数据很少。我们还建议对 ECHO 进行简短、低负担的扩展 更好地描述农村化学品暴露情况以及空气质量指数 (AQI) 知识的协议 探讨获得这一公共卫生工具的差异，并评估其在减轻健康影响方面的有效性。 拟议的野火快速响应协议将支持野火相关的自然实验分析 健康危机。总体而言，ECHO AWARE 建立在之前的成功经验和作为 ECHO 获得的见解的基础上 PATHWAYS 项目协调和团队科学多队列奖励中心点；我们继续这些 ECHO 2.0 的工作重点是面向解决方案的研究、社区参与和翻译。