ECHO in Agricultural Washington and Rural Environments (ECHO AWARE)

摘要 ECHO AWARE（ECHO在农业华盛顿和农村环境）丰富了ECHO计划， 两种主要方式。1)我们将增加农村和农业社区的代表性，特别是拉丁美洲人 家庭，在ECHO队列中。农村儿童在健康和环境暴露方面存在许多差异， 但在研究和目前的ECHO队列中代表性很差。通过深入的社区参与 研究联系到华盛顿的农业亚基马谷，我们的团队准备招募1000多名孕妇 个人通过与他们的医疗之家和联邦合格的健康中心（亚基马谷 农场工人诊所）。我们还与传统大学合作，让拉丁裔和雅卡马民族参与进来。 本科生和初级教师交流关于ECHO研究实践的观点，并培养 在这个环境正义社区的生物医学职业发展。生物标本采集将由 一个有经验的小组指导一个生物储存库，用于超过10,000次怀孕。2)我们的调查员团队（多元化 在职业阶段，科学学科，机构，文化背景）促进ECHO合作科学， 空气污染、呼吸道健康和农村健康。我们建议建立一个新的跨队列农村卫生工作组， 欧盟人道处的一系列手稿，以了解资源不足和 美国农村的少数民族社区，以及与这些难以接触的人接触的最佳做法。 人口数量。一组新的先入之见分析解决了广泛的污染物的关注， 饮用水威尔斯，这是欧共体人道处尚未充分研究的问题。我们还利用数十年的空气污染专业知识 扩大可用于ECHO分析的空气污染暴露，并进行以解决方案为导向的研究， 直接告知美国监管政策和公共健康促进计划。我们的团队提供专业知识， 空气污染的先进方法，包括接触混合物的方法。我们还带来了新的国家模式 对于ECHO新出现的关注的室外空气污染物，包括野火烟雾（WFS）和超细 颗粒物（UFP）。我们首先为WFS开发一个改进的国家模型， 研究这一气候变化驱动的灾难，并导致手稿描述对美国儿童的影响。 然后，我们开发了一个新的国家模型的UFP，一个不受管制的污染物表现出高毒性的潜力， 动物模型，但几乎没有流行病学数据。我们还建议对ECHO进行简短、低负担的扩展 关于更好地描述农村化学品接触情况以及了解空气质量指数的议定书， 探讨在获得这一公共卫生工具方面的差距，并评价其在减轻健康影响方面的效力。 拟议的野火快速反应协议将支持野火相关的自然实验分析 健康危机。总的来说，ECHO AWARE建立在先前的成功和作为ECHO PATHWAYS项目协调和团队科学的多队列奖励中心点;我们继续这些 在ECHO 2.0方面的努力，重点是面向解决方案的研究，社区参与和翻译。

ABSTRACT ECHO AWARE (ECHO in Agricultural Washington and Rural Environments) enriches the ECHO Program in two primary ways. 1) We will increase representation of rural and agricultural communities, particularly Latino families, in the ECHO Cohort. Rural children experience many health and environmental exposure disparities, yet are poorly represented in research and in the current ECHO Cohort. With deep community-engaged research ties to Washington’s agricultural Yakima Valley, our team is poised to enroll over 1000 pregnant individuals through partnership with their medical home and Federally Qualified Health Center (Yakima Valley Farm Workers Clinic). We also partner with Heritage University to involve Latino and Yakama Nation undergraduates and junior faculty to exchange perspectives regarding ECHO research practice and foster biomedical career development in this environmental justice community. Biospecimen collection will be led by a subteam with experience directing a biorepository for >10,000 pregnancies. 2) Our investigator team (diverse in career stage, scientific discipline, institution, cultural background) advances ECHO collaborative science in air pollution, airway health, and rural health. We propose a new cross-cohort Rural Health Workgroup plus a series of ECHO manuscripts to understand the health conditions and risk factors for under-resourced and minoritized communities in rural America, as well as best practices for engaging these hard-to-reach populations. A set of novel preconception analyses addresses widespread contaminants of concern for drinking water wells, an underdeveloped topic for ECHO. We also leverage decades of air pollution expertise to expand the air pollution exposures available for ECHO analyses and conduct solution-oriented research to directly inform U.S. regulatory policy and public health promotion programs. Our team contributes expertise in advanced methods for air pollution, including those for exposure mixtures. We also bring new national models for outdoor air pollutants of emerging concern to ECHO, including wildfire smoke (WFS) and ultrafine particulate matter (UFP). We first develop an improved national model for WFS to enable much-needed research on this climate-change driven catastrophe and lead manuscripts to describe impacts on US children. We then develop a new national model of UFP, an unregulated pollutant demonstrating high toxic potential in animal models yet with little epidemiological data. We also propose brief, low-burden extensions to the ECHO Protocol to better characterize rural chemical exposures as well as knowledge of the Air Quality Index (AQI) to explore disparities in access to this public health tool and evaluate its effectiveness in mitigating health effects. A proposed Wildfire Rapid Response Protocol will support natural experiment analyses of wildfire related health crises. Overall, ECHO AWARE builds on prior successes and insights gained as the ECHO PATHWAYS multi-cohort award center point for project coordination and team science; we continue these efforts in ECHO 2.0 with a focus on solution-oriented research, community-engagement, and translation.