Vaping Nicotine and Cannabis Across Adolescence and Young Adulthood

青少年和青年时期吸食尼古丁和大麻

• 批准号: 10747805
• 负责人: Jessica Louise Barrington-Trimis
• 金额: $ 13.07万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10747805
• 关键词: Address; Adolescence; Adolescent and Young Adult; Adverse effects; Aftercare; Age; Age Months; Award; Back; Behavioral; Cannabinoids; Cannabis; Characteristics; Chronic; Cigarette; Community Health; Cross-Sectional Studies; Data; Decision Making; Dedications; Dependence; Development; Disease; Drug usage; Education; Electronics; Emotional; Environment; Epidemic; Expectancy; Female; Flavoring; Freedom; Friends; Future; Gender; Health; Individual; Inhalation; Intervention; Interview; JUUL; Left; Life Experience; Malignant Neoplasms; Marijuana Smoking; Measures; Modeling; Moods; Motivation; Nicotine; Oils; Oral; Outcome; Parents; Participant; Pattern; Persons; Plants; Play; Policies; Population; Predisposition; Prevention; Prevention strategy; Problem behavior; Proliferating; Public Health; Relapse; Reporting; Research; Rewards; Risk; Risk Factors; Role; Schools; Self Administration; Smoking; Social Environment; Stress; Students; Surveys; Technology; Testing; Tobacco; Tobacco use; Tobacco-Related Carcinoma; Uncertainty; Variant; Waxes; Women' s Health; Youth; adverse outcome; aged; biopsychosocial; catalyst; cigarette smoking; cohort; combustible tobacco; coping; craving; design; deviant; electronic cigarette use; emerging adult; emotion regulation; empowerment; experience; experimental study; flexibility; habituation; health goals; heated tobacco products; high-risk adolescents; insight; intergenerational; male; marijuana use; marijuana vaping; multiple drug use; nicotine exposure; nicotine use; ninth grade; novel; parent grant; parent project; pleasure; polysubstance use; prevent; programs; progression risk; public health priorities; recruit; response; self esteem; smoking initiation; social; substance use; theories; therapy design; tobacco products; trend; uptake; vaping; vaping nicotine; young adult

PROJECT SUMMARY (PARENT AWARD R01CA229617) In 2015, evidence that e-cigarette use ("vaping") in adolescents and young adults (AYAs) had increased and was associated with increased risk of cigarette smoking initiation generated concern in the public health community. Subsequent research has left the field with several critical questions, including: (1) whether vaping truly has a causal effect on smoking or merely reflects a common liability toward deviancy among 'high-risk' AYAs with emotional or behavioral problems, (2) whether an emerging wave of new vaping products, including new nicotine products such as JUUL, and an increasingly diverse class of products dedicated to vaping cannabis plant, oils, and waxes, may increase the appeal and addictive potential of vaping, and (3) whether there exist particular characteristics of vaping products and biopsychosocial mechanisms that underlie the risk of AYA vaping initiation, progression, and transition to other forms of drug use that could be targeted in prevention efforts. The uncertainties regarding the impact of AYA vaping have left policy officials with little evidence to determine if AYA vaping should be prioritized in public health programs, and if so, the most effective strategies for prevention. To address the evidence needs and provide a flexible framework for future study of the impact of various vaping products on the AYA tobacco product and cannabis use burden, we will test a novel 'catalyst model' of AYA vaping. The catalyst model proposes two steps, which we will evaluate in Aims 1 and 2 of this proposal. Step 1 (AIM 1 ). To determine whether (a) AYAs with fewer emotional-behavioral risk factors who have been previously deterred from drug use in traditional (non-vaporized) forms are at risk of vaping initiation, (b) the unique qualities and product features of vaping (e.g., concealability, flavors, appealing technology, social acceptability, low perceived harm) increase risk of AYA vaping, and (c) features of vaping products disproportionately increase the risk of vaping initiation for low-risk AYAs. Step 2 (AIM 2). To determine whether (a) vaping increases the risk of cross-product transitions involving initiation of other vaping products, or combustible nicotine or cannabis, as well as increases risk of progression to problematic drug use outcomes, including dependence, poly-drug use, and chronic drug use through early adulthood, (b) rewarding effects from exposure to nicotine, cannabinoids, and other product components (e.g. flavorings) increases risk of cross-product transitions and problematic drug use outcomes, and (c) product characteristics modify this association. To test the model, we will leverage data collected from participants from age 14-19 (2013-2018) from our existing cohort and follow participants into early adulthood (20-23, from 2019-2023; N-2000). We will also recruit a new cohort of 9th grade students at age 14 (N=2500) at the same schools as part of a cohort-sequential design that will apply causal inference analytic approaches to determine whether observed associations are likely causal. Collectively, this project will provide critical information regarding the priority and potential targets of public health efforts aimed at reducing the potential adverse public health effects resulting from AYA vaping, including tobacco-related cancer.

项目摘要（家长奖R01CA229617） 2015年，有证据表明，青少年和年轻人（AYA）中使用电子烟（“烟”）有所增加，并且与增加吸烟启动的风险增加有关，这引起了公共卫生社区的关注。 Subsequent research has left the field with several critical questions, including: (1) whether vaping truly has a causal effect on smoking or merely reflects a common liability toward deviancy among 'high-risk' AYAs with emotional or behavioral problems, (2) whether an emerging wave of new vaping products, including new nicotine products such as JUUL, and an increasingly diverse class of products dedicated to vaping cannabis plant, oils, and waxes,可能会增加烟雾的吸引力和上瘾的潜力，以及（3）是否存在烟产品和生物心理社会机制的特征，这些机制是AYA vaping启动，进步，进展和过渡到其他形式的药物使用的风险，这些风险可能针对预防努力。关于AYA烟的影响的不确定性使政策官员几乎没有证据来确定是否应在公共卫生计划中优先考虑AYA Vaping，如果是这样，则是预防预防的最有效策略。 为了满足证据需求并为未来研究各种烟产品对AYA烟草产品和大麻使用负担的影响提供灵活的框架，我们将测试AYA Vaping的新型“催化剂模型”。催化剂模型提出了两个步骤，我们将在本提案的目标1和2中评估。步骤1（目标1）。 To determine whether (a) AYAs with fewer emotional-behavioral risk factors who have been previously deterred from drug use in traditional (non-vaporized) forms are at risk of vaping initiation, (b) the unique qualities and product features of vaping (e.g., concealability, flavors, appealing technology, social acceptability, low perceived harm) increase risk of AYA vaping, and (c) features of vaping products disproportionately increase低风险AYA的烟雾启动的风险。步骤2（目标2）。 To determine whether (a) vaping increases the risk of cross-product transitions involving initiation of other vaping products, or combustible nicotine or cannabis, as well as increases risk of progression to problematic drug use outcomes, including dependence, poly-drug use, and chronic drug use through early adulthood, (b) rewarding effects from exposure to nicotine, cannabinoids, and other product components (e.g. flavorings)增加了跨产物过渡和有问题的药物使用结果的风险，并且（c）产品特征改变了这种关联。为了测试该模型，我们将利用从我们现有队列的14-19岁（2013-2018）从参与者那里收集的数据，并跟随参与者成年（20-23，2019-2023; N-2000）。我们还将在同一学校中招募14岁（n = 2500）的9年级学生的新队列，作为同类序列设计的一部分，该设计将采用因果推理分析方法来确定观察到的关联是否可能是因果关系。总的来说，该项目将提供有关旨在减少AYA蒸发造成的潜在不利公共卫生影响的公共卫生工作的优先级和潜在目标的关键信息，包括与烟草相关的癌症。