Vaping Nicotine and Cannabis Across Adolescence and Young Adulthood

青少年和青年时期吸食尼古丁和大麻

基本信息

批准号：
10022101
负责人：
Jessica Louise Barrington-Trimis
金额：
$ 35.43万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-20 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10022101
关键词：
Address Adolescence Adolescent and Young Adult Adverse effects Age Age-Months Anxiety Disorders Attention deficit hyperactivity disorder Behavioral California Cannabinoids Cannabis Characteristics Chronic Cigarette Community Health Data Data Sources Dependence Development Devices Disease Drug abuse Drug usage Electronics Emotional Expectancy Flavoring Future Health High School Student Impulsivity Inhalation Intervention JUUL Lead Left Link Malignant Neoplasms Marijuana Smoking Measures Mediating Modeling Mood Disorders Nicotine Outcome Palate Participant Pharmaceutical Preparations Plant Oils Play Policies Policy Maker Population Prevention Prevention strategy Problem behavior Public Health Research Rewards Risk Risk Factors Role Sampling Schools Science Scientist Self Administration Smoking Students Surveys THC concentration Technology Testing Tobacco Tobacco use Tobacco-Related Carcinoma Uncertainty Variant Waxes Youth adverse outcome aged biopsychosocial catalyst cigarette smoking cohort design deviant digital distress tolerance electronic cigarette use emerging adult experience experimental study flexibility follow-up habituation heated tobacco products high risk high school high-risk adolescents marijuana use marijuana vaping nicotine exposure nicotine use ninth grade novel prevent programs public health priorities recruit social stem tobacco products trait uptake vaping vaping nicotine vapor young adult

项目摘要

! PROJECT SUMMARY In 2015, evidence that e-cigarette use (“vaping”) in adolescents and young adults (AYAs) had increased and was associated with increased risk of cigarette smoking initiation generated concern in the public health community. Subsequent research has left the field with several critical questions, including: (1) whether vaping truly has a causal effect on smoking or merely reflects a common liability toward deviancy among ‘high-risk’ AYAs with emotional or behavioral problems, (2) whether an emerging wave of new vaping products, including new nicotine products such as JUUL, and an increasingly diverse class of products dedicated to vaping cannabis plant, oils, and waxes, may increase the appeal and addictive potential of vaping, and (3) whether there exist particular characteristics of vaping products and biopsychosocial mechanisms that underlie the risk of AYA vaping initiation, progression, and transition to other forms of drug use that could be targeted in prevention efforts. The uncertainties regarding the impact of AYA vaping have left policy officials with little evidence to determine if AYA vaping should be prioritized in public health programs, and if so, the most effective strategies for prevention. To address the evidence needs and provide a flexible framework for future study of the impact of various vaping products on the AYA tobacco product and cannabis use burden, we will test a novel ‘catalyst model’ of AYA vaping. The catalyst model proposes two steps, which we will evaluate in Aims 1 and 2 of this proposal. Step 1 (AIM 1). To determine whether (a) AYAs with fewer emotional-behavioral risk factors who have been previously deterred from drug use in traditional (non-vaporized) forms are at risk of vaping initiation, (b) the unique qualities and product features of vaping (e.g., concealability, flavors, appealing technology, social acceptability, low perceived harm) increase risk of AYA vaping, and (c) features of vaping products disproportionately increase the risk of vaping initiation for low-risk AYAs. Step 2 (AIM 2). To determine whether (a) vaping increases the risk of cross-product transitions involving initiation of other vaping products, or combustible nicotine or cannabis, as well as increases risk of progression to problematic drug use outcomes, including dependence, poly-drug use, and chronic drug use through early adulthood, (b) rewarding effects from exposure to nicotine, cannabinoids, and other product components (e.g. flavorings) increases risk of cross-product transitions and problematic drug use outcomes, and (c) product characteristics modify this association. To test the model, we will leverage data collected from participants from age 14-19 (2013-2018) from our existing cohort and follow participants into early adulthood (20-23, from 2019-2023; N~2000). We will also recruit a new cohort of 9th grade students at age 14 (N=2500) at the same schools as part of a cohort-sequential design that will apply causal inference analytic approaches to determine whether observed associations are likely causal. Collectively, this project will provide critical information regarding the priority and potential targets of public health efforts aimed at reducing the potential adverse public health effects resulting from AYA vaping, including tobacco-related cancer.

呢项目摘要 2015年，有证据表明青少年和年轻人（AYA）中使用电子烟（“烟”）有所增加，并且与增加吸烟计划的风险增加有关，引起了公共卫生社区的关注。随后的研究使该领域带来了几个关键问题，包括：（1）烟是否是否真的对吸烟有因果关系，或仅反映了“高风险” AYAS中对魔鬼的共同责任有情感或行为问题，（2）新兴的新烟产品浪潮是否包括新产品尼古丁产品（例如Juul），以及越来越多样化的产品，专门用于蒸发大麻植物，油和蜡可能会增加蒸发的外观和添加剂，（3）是否存在 Vaping产品和生物心理社会机制的特殊特征是AYA Vaping倡议，进步和过渡到其他形式的药物使用的风险，这些风险可能针对预防工作。关于AYA烟的影响的不确定性使政策官员几乎没有证据来确定是否是否 AYA烟应该在公共卫生计划中优先考虑，如果是的，则应是预防的最有效策略。解决证据需求，并为将来研究各种烟的影响提供灵活的框架 AYA烟草产品和大麻使用Burnen的产品，我们将测试AYA的新型“催化剂模型” 烟。催化剂模型提出了两个步骤，我们将在本提案的目标1和2中评估。步骤1 （目标1）。确定（a）AYA是否具有以前的情感行为风险因素较少由传统（非蒸发）形式中的毒品使用确定有烟计划的风险，（b）独特的品质烟的产品（例如隐藏性，风味，吸引人的技术，社会可接受性，低感知伤害）的产品功能增加了AYA烟的风险，（c）烟产品的特征不成比例地增加低风险AYA的风险风险。步骤2（目标2）。确定（a）烟是否会增加涉及其他vaping产品或混合尼古丁或大麻的主动性的跨产品过渡以及增加进展为有问题的药物使用结果的风险，包括依赖性，多药的使用，（b）暴露于尼古丁，大麻素，和其他产品成分（例如调味剂）增加了跨产品过渡和问题药物的风险使用结果，（c）产品特性修改了此关联。要测试模型，我们将利用数据从14-19岁（2013-2018）从我们现有队列的参与者那里收集，并跟随参与者提早成年（20-23，2019 - 2023年； n〜2000）。我们还将在14岁时招募新的9年级学生（n = 2500）在同一学校中，作为同类序列设计的一部分，该设计将适用因果推理分析确定观察到的关联是否可能是因果的方法。该项目共同提供有关旨在减少AYA蒸发造成的潜在不利公共卫生影响（包括与烟草相关的癌症）的潜在不利公共卫生影响的关键信息，旨在减少潜在的不利公共卫生影响。